Members

Aijun Wang
Associate Professor
Associate Investigator
Co-Director, Surgical Bioengineering Laboratory Dept. Of Surgery
University of California, Davis
4625 2nd Ave., Research II, Room 3005, Sacramento, CA 95817
(916) 703-0422
aawang (at) ucdavis.edu
Education
- Department of Surgery, University of California, Davis
- Department of Biomedical Engineering, University of California, Davis
- Ph.D. Biomaterials and Tissue engineering, Tsinghua University, Beijing, China
- Post-Doc, Bioengineering, University of California Berkeley
- Post-Doc, Stem cell engineering, Berkeley Stem Cell Center, California Institute for Regenerative Medicine (CIRM)
Research Interests
Stem cell engineering, biomaterial engineering, tissue engineering, fetal tissue engineering, fetal treatment of birth defects, vascular and neural tissue regeneration, wound healing
Dr. Wang’s research focuses on developing novel technologies that combine stem cell engineering and biomaterial engineering to promote tissue regeneration. The Wang Group focuses on the engineering and development of stem cells, stem cell-derived exosomes and biomaterial-based scaffolds for the treatment of a variety of surgical diseases. Projects include engineering stem cells and stem cell-derived exosomes for improved therapeutic functions and targeted delivery; engineering biomaterial scaffolds by using instructive ligands for stem cell culture, delivery and recruitment; evaluating stem cell and biomaterial products in experimental animal models and naturally occurring disease models.
Please see: Dr. Wang’s laboratory website for more information.
2019
Tan J, Xie Y, Yao A, Qin Y, Li L, Shen L, Zhang X, Xu C, Jiang X, Wang A, Yan Z. Long noncoding RNA-dependent regulation of vascular smooth muscle cell proliferation and migration in hypertension. Int J Biochem Cell Biol. 2020 Jan;118:105653. doi: 10.1016/j.biocel.2019.105653. Epub 2019 Nov 16. PubMed PMID: 31743794. Download PDF
Henry JJD, Delrosario L, Fang J, Wong SY, Fang Q, Sievers R, Kotha S, Wang A, Farmer D, Janaswamy P, Lee RJ, Li S. Development of Injectable Amniotic Membrane Matrix for Postmyocardial Infarction Tissue Repair. Adv Healthc Mater. 2020 Jan;9(2):e1900544. doi: 10.1002/adhm.201900544. Epub 2019 Nov 28. PubMed PMID: 31778043; PubMed Central PMCID: PMC6986802. Download PDF
Ramasubramanian L, Kumar P, Wang A. Engineering Extracellular Vesicles as Nanotherapeutics for Regenerative Medicine. Biomolecules. 2019 Dec 28;10(1). doi: 10.3390/biom10010048. Review. PubMed PMID: 31905611; PubMed Central PMCID: PMC7023093. Download PDF
Clark K, Zhang S, Barthe S, Kumar P, Pivetti C, Kreutzberg N, Reed C, Wang Y, Paxton Z, Farmer D, Guo F, Wang A. Placental Mesenchymal Stem Cell-Derived Extracellular Vesicles Promote Myelin Regeneration in an Animal Model of Multiple Sclerosis. Cells. 2019 Nov 23;8(12). doi: 10.3390/cells8121497. PubMed PMID: 31771176; PubMed Central PMCID: PMC6952942. Download PDF
Hao D, He C, Ma B, Lankford L, Reynaga L, Farmer DL, Guo F, Wang A. Hypoxic Preconditioning Enhances Survival and Proangiogenic Capacity of Human First Trimester Chorionic Villus-Derived Mesenchymal Stem Cells for Fetal Tissue Engineering. Stem Cells Int. 2019;2019:9695239. doi: 10.1155/2019/9695239. eCollection 2019. PubMed PMID: 31781252; PubMed Central PMCID: PMC6874947. Download PDF
Liao J, Chen Y, Chen J, He B, Qian L, Xu J, Wang A, Li Q, Xie H, Zhou J. Auricle shaping using 3D printing and autologous diced cartilage. Laryngoscope. 2019 Nov;129(11):2467-2474. doi: 10.1002/lary.27752. Epub 2019 Mar 7. PubMed PMID: 30843613; PubMed Central PMCID: PMC6850318. Download PDF
Xue YN, Yan Y, Chen ZZ, Chen J, Tang FJ, Xie HQ, Tang SJ, Cao K, Zhou X, Wang AJ, Zhou JD. LncRNA TUG1 regulates FGF1 to enhance endothelial differentiation of adipose-derived stem cells by sponging miR-143. J Cell Biochem. 2019 Nov;120(11):19087-19097. doi: 10.1002/jcb.29232. Epub 2019 Jul 1. PubMed PMID: 31264280. Download PDF
Goldbloom-Helzner L, Hao D, Wang A. Developing Regenerative Treatments for Developmental Defects, Injuries, and Diseases Using Extracellular Matrix Collagen-Targeting Peptides. Int J Mol Sci. 2019 Aug 21;20(17). doi: 10.3390/ijms20174072. Review. PubMed PMID: 31438477; PubMed Central PMCID: PMC6747276. Download PDF
Liu C, Chen W, Chen Z, Yan Y, Wang Q, Xie H, Chen X, Wang A, Tang S, Zhou J. Studies on the treatment of melanoma with folate acid conjugated dextran and lauryl alcohol loaded with IMD0354. Onco Targets Ther. 2019;12:4655-4663. doi: 10.2147/OTT.S207685. eCollection 2019. PubMed PMID: 31354298; PubMed Central PMCID: PMC6585409. Download PDF
Kumar P, Becker JC, Gao K, Carney RP, Lankford L, Keller BA, Herout K, Lam KS, Farmer DL, Wang A. Neuroprotective effect of placenta-derived mesenchymal stromal cells: role of exosomes. FASEB J. 2019 May;33(5):5836-5849. doi: 10.1096/fj.201800972R. Epub 2019 Feb 12. PubMed PMID: 30753093; PubMed Central PMCID: PMC6463921. Download PDF
Zhu Y, Li X, Janairo RRR, Kwong G, Tsou AD, Chu JS, Wang A, Yu J, Wang D, Li S. Matrix stiffness modulates the differentiation of neural crest stem cells in vivo. J Cell Physiol. 2019 May;234(5):7569-7578. doi: 10.1002/jcp.27518. Epub 2018 Oct 26. PubMed PMID: 30368818; PubMed Central PMCID: PMC6995283. Download PDF
Vanover M, Pivetti C, Galganski L, Kumar P, Lankford L, Rowland D, Paxton Z, Deal B, Wang A, Farmer D. Spinal Angulation: A Limitation of the Fetal Lamb Model of Myelomeningocele. Fetal Diagn Ther. 2019;46(6):376-384. doi: 10.1159/000496201. Epub 2019 Apr 10. PubMed PMID: 30970373; PubMed Central PMCID: PMC7353925. Download PDF
Chen Y, Cao K, Li J, Wang A, Sun L, Tang J, Xiong W, Zhou X, Chen X, Zhou J, Liu Y. Overexpression of long non-coding RNA NORAD promotes invasion and migration in malignant melanoma via regulating the MIR-205-EGLN2 pathway. Cancer Med. 2019 Apr;8(4):1744-1754. doi: 10.1002/cam4.2046. Epub 2019 Mar 7. PubMed PMID: 30843652; PubMed Central PMCID: PMC6488211. Download PDF
Hu F, Yan Y, Wang CW, Liu Y, Wang JJ, Zhou F, Zeng QH, Zhou X, Chen J, Wang AJ, Zhou JD. Article Effect and Mechanism of Ganoderma lucidum Polysaccharides on Human Fibroblasts and Skin Wound Healing in Mice. Chin J Integr Med. 2019 Mar;25(3):203-209. doi: 10.1007/s11655-018-3060-9. Epub 2018 Dec 15. PubMed PMID: 30552545. Download PDF
Li J, Chen J, Wang S, Li P, Zheng C, Zhou X, Tao Y, Chen X, Sun L, Wang A, Cao K, Tang S, Zhou J. Blockage of transferred exosome-shuttled miR-494 inhibits melanoma growth and metastasis. J Cell Physiol. 2019 Feb 5;. doi: 10.1002/jcp.28234. [Epub ahead of print] PubMed PMID: 30723916. Download PDF
Long C, Lankford L, Wang A. Stem cell-based in utero therapies for spina bifida: implications for neural regeneration. Neural Regen Res. 2019 Feb;14(2):260-261. doi: 10.4103/1673-5374.244786. PubMed PMID: 30531007; PubMed Central PMCID: PMC6301160. Download PDF
Gao K, Kumar P, Cortez-Toledo E, Hao D, Reynaga L, Rose M, Wang C, Farmer D, Nolta J, Zhou J, Zhou P, Wang A. Potential long-term treatment of hemophilia A by neonatal co-transplantation of cord blood-derived endothelial colony-forming cells and placental mesenchymal stromal cells. Stem Cell Res Ther. 2019 Jan 22;10(1):34. doi: 10.1186/s13287-019-1138-8. PubMed PMID: 30670078; PubMed Central PMCID: PMC6341603. Download PDF
Zhou Z, Jiang H, Tu K, Yu W, Zhang J, Hu Z, Zhang H, Hao D, Huang P, Wang J, Wang A, Xiao Z, He C. ANKHD1 is required for SMYD3 to promote tumor metastasis in hepatocellular carcinoma. J Exp Clin Cancer Res. 2019 Jan 15;38(1):18. doi: 10.1186/s13046-018-1011-0. PubMed PMID: 30646949; PubMed Central PMCID: PMC6332640. Download PDF
Zhang Z, Du J, Wang S, Shao L, Jin K, Li F, Wei B, Ding W, Fu P, van Dam H, Wang A, Jin J, Ding C, Yang B, Zheng M, Feng XH, Guan KL, Zhang L. OTUB2 Promotes Cancer Metastasis via Hippo-Independent Activation of YAP and TAZ. Mol Cell. 2019 Jan 3;73(1):7-21.e7. doi: 10.1016/j.molcel.2018.10.030. Epub 2018 Nov 21. PubMed PMID: 30472188. Download PDF
Vanover M, Pivetti C, Lankford L, Kumar P, Galganski L, Kabagambe S, Keller B, Becker J, Chen YJ, Chung K, Lee C, Paxton Z, Deal B, Goodman L, Anderson J, Jensen G, Wang A, Farmer D. High density placental mesenchymal stromal cells provide neuronal preservation and improve motor function following in utero treatment of ovine myelomeningocele. J Pediatr Surg. 2019 Jan;54(1):75-79. doi: 10.1016/j.jpedsurg.2018.10.032. Epub 2018 Oct 4. PubMed PMID: 30529115; PubMed Central PMCID: PMC6339576. Download PDF
2018
Zhang S, Rasai A, Wang Y, Xu J, Bannerman P, Erol D, Tsegaye D, Wang A, Soulika A, Zhan X, Guo F. The Stem Cell Factor Sox2 Is a Positive Timer of Oligodendrocyte Development in the Postnatal Murine Spinal Cord. Mol Neurobiol. 2018 Dec;55(12):9001-9015. doi: 10.1007/s12035-018-1035-7. Epub 2018 Apr 5. PubMed PMID: 29623612; PubMed Central PMCID: PMC6173662. Download PDF
Phan J, Kumar P, Hao D, Gao K, Farmer D, Wang A. Engineering mesenchymal stem cells to improve their exosome efficacy and yield for cell-free therapy. J Extracell Vesicles. 2018;7(1):1522236. doi: 10.1080/20013078.2018.1522236. eCollection 2018. Review. PubMed PMID: 30275938; PubMed Central PMCID: PMC6161586. Download PDF
Wang Q, Chen J, Wang A, Sun L, Qian L, Zhou X, Liu Y, Tang S, Chen X, Cheng Y, Cao K, Zhou J. Differentially expressed circRNAs in melanocytes and melanoma cells and their effect on cell proliferation and invasion. Oncol Rep. 2018 Apr;39(4):1813-1824. doi: 10.3892/or.2018.6263. Epub 2018 Feb 13. PubMed PMID: 29436673.
Ryzhuk V, Zeng XX, Wang X, Melnychuk V, Lankford L, Farmer D, Wang A. Human amnion extracellular matrix derived bioactive hydrogel for cell delivery and tissue engineering. Mater Sci Eng C Mater Biol Appl. 2018 Apr 1;85:191-202. doi: 10.1016/j.msec.2017.12.026. Epub 2017 Dec 21. PubMed PMID: 29407148; PubMed Central PMCID: PMC6353560. Download PDF
Zhang S, Zhu X, Gui X, Croteau C, Song L, Xu J, Wang A, Bannerman P, Guo F. Sox2 Is Essential for Oligodendroglial Proliferation and Differentiation during Postnatal Brain Myelination and CNS Remyelination. J Neurosci. 2018 Feb 14;38(7):1802-1820. doi: 10.1523/JNEUROSCI.1291-17.2018. Epub 2018 Jan 15. PubMed PMID: 29335358; PubMed Central PMCID: PMC5815459. Download PDF
Long C, Lankford L, Kumar P, Grahn R, Borjesson DL, Farmer D, Wang A. Isolation and characterization of canine placenta-derived mesenchymal stromal cells for the treatment of neurological disorders in dogs. Cytometry A. 2018 Jan;93(1):82-92. doi: 10.1002/cyto.a.23171. Epub 2017 Jul 17. PubMed PMID: 28715613.
Kumar P, Gao K, Wang C, Pivetti C, Lankford L, Farmer D, Wang A. In Utero Transplantation of Placenta-Derived Mesenchymal Stromal Cells for Potential Fetal Treatment of Hemophilia A. Cell Transplant. 2018 Jan;27(1):130-139. doi: 10.1177/0963689717728937. PubMed PMID: 29562772; PubMed Central PMCID: PMC6434487. Download PDF
Wang D, Li LK, Dai T, Wang A, Li S. Adult Stem Cells in Vascular Remodeling. Theranostics. 2018;8(3):815-829. doi: 10.7150/thno.19577. eCollection 2018. Review. PubMed PMID: 29344309; PubMed Central PMCID: PMC5771096. Download PDF
2017
Chang TY, Chen C, Lee M, Chang YC, Lu CH, Lu ST, Wang DY, Wang A, Guo CL, Cheng PL. Paxillin facilitates timely neurite initiation on soft-substrate environments by interacting with the endocytic machinery. Elife. 2017 Dec 22;6. doi: 10.7554/eLife.31101. PubMed PMID: 29271742; PubMed Central PMCID: PMC5768420. Download PDF
Huang CW, Huang WC, Qiu X, Fernandes Ferreira da Silva F, Wang A, Patel S, Nesti LJ, Poo MM, Li S. The Differentiation Stage of Transplanted Stem Cells Modulates Nerve Regeneration. Sci Rep. 2017 Dec 12;7(1):17401. doi: 10.1038/s41598-017-17043-4. PubMed PMID: 29234013; PubMed Central PMCID: PMC5727226. Download PDF
Kabagambe SK, Lankford L, Kumar P, Chen YJ, Herout KT, Lee CJ, Stark RA, Farmer DL, Wang A. Isolation of myogenic progenitor cell population from human placenta: A pilot study. J Pediatr Surg. 2017 Dec;52(12):2078-2082. doi: 10.1016/j.jpedsurg.2017.08.025. Epub 2017 Sep 4. PubMed PMID: 28964407. Download PDF
Chen YJ, Lankford L, Kabagambe S, Saenz Z, Kumar P, Farmer D, Wang A. Effect of 2-octylcyanoacrylate on placenta derived mesenchymal stromal cells on extracellular matrix. Placenta. 2017 Nov;59:163-168. doi: 10.1016/j.placenta.2017.03.022. Epub 2017 Apr 2. PubMed PMID: 28465002. Download PDF
Vanover M, Wang A, Farmer D. Potential clinical applications of placental stem cells for use in fetal therapy of birth defects. Placenta. 2017 Nov;59:107-112. doi: 10.1016/j.placenta.2017.05.010. Epub 2017 May 18. Review. PubMed PMID: 28651900. Download PDF
Cao K, Li J, Chen J, Qian L, Wang A, Chen X, Xiong W, Tang J, Tang S, Chen Y, Chen Y, Cheng Y, Zhou J. microRNA-33a-5p increases radiosensitivity by inhibiting glycolysis in melanoma. Oncotarget. 2017 Oct 13;8(48):83660-83672. doi: 10.18632/oncotarget.19014. eCollection 2017 Oct 13. PubMed PMID: 29137372; PubMed Central PMCID: PMC5663544. Download PDF
Chen YJ, Chung K, Pivetti C, Lankford L, Kabagambe SK, Vanover M, Becker J, Lee C, Tsang J, Wang A, Farmer DL. Fetal surgical repair with placenta-derived mesenchymal stromal cell engineered patch in a rodent model of myelomeningocele. J Pediatr Surg. 2017 Oct 12;. doi: 10.1016/j.jpedsurg.2017.10.040. [Epub ahead of print] PubMed PMID: 29096888. Download PDF
Liao JL, Chen J, He B, Chen Y, Xu JQ, Xie HJ, Hu F, Wang AJ, Luo C, Li QF, Zhou JD. Viability and Biomechanics of Diced Cartilage Blended With Platelet-Rich Plasma and Wrapped With Poly (Lactic-Co-Glycolic) Acid Membrane. J Craniofac Surg. 2017 Sep;28(6):1418-1424. doi: 10.1097/SCS.0000000000003739. PubMed PMID: 28692513. Download PDF
Wang D, Wu F, Yuan H, Wang A, Kang GJ, Truong T, Chen L, McCallion AS, Gong X, Li S. Sox10+ Cells Contribute to Vascular Development in Multiple Organs-Brief Report. Arterioscler Thromb Vasc Biol. 2017 Sep;37(9):1727-1731. doi: 10.1161/ATVBAHA.117.309774. Epub 2017 Jul 27. PubMed PMID: 28751573; PubMed Central PMCID: PMC5572822. Download PDF
Henry JJD, Yu J, Wang A, Lee R, Fang J, Li S. Engineering the mechanical and biological properties of nanofibrous vascular grafts for in situ vascular tissue engineering. Biofabrication. 2017 Aug 17;9(3):035007. doi: 10.1088/1758-5090/aa834b. PubMed PMID: 28817384; PubMed Central PMCID: PMC5847368. Download PDF
Lankford L, Chen YJ, Saenz Z, Kumar P, Long C, Farmer D, Wang A. Manufacture and preparation of human placenta-derived mesenchymal stromal cells for local tissue delivery. Cytotherapy. 2017 Jun;19(6):680-688. doi: 10.1016/j.jcyt.2017.03.003. Epub 2017 Apr 21. PubMed PMID: 28438482. Download PDF
Hao D, Xiao W, Liu R, Kumar P, Li Y, Zhou P, Guo F, Farmer DL, Lam KS, Wang F, Wang A. Discovery and Characterization of a Potent and Specific Peptide Ligand Targeting Endothelial Progenitor Cells and Endothelial Cells for Tissue Regeneration. ACS Chem Biol. 2017 Apr 21;12(4):1075-1086. doi: 10.1021/acschembio.7b00118. Epub 2017 Mar 2. PubMed PMID: 28195700; PubMed Central PMCID: PMC5875449. Download PDF
Harding A, Cortez-Toledo E, Magner NL, Beegle JR, Coleal-Bergum DP, Hao D, Wang A, Nolta JA, Zhou P. Highly Efficient Differentiation of Endothelial Cells from Pluripotent Stem Cells Requires the MAPK and the PI3K Pathways. Stem Cells. 2017 Apr;35(4):909-919. doi: 10.1002/stem.2577. Epub 2017 Mar 1. PubMed PMID: 28248004.
Wang D, Wang A, Wu F, Qiu X, Li Y, Chu J, Huang WC, Xu K, Gong X, Li S. Sox10+ adult stem cells contribute to biomaterial encapsulation and microvascularization. Sci Rep. 2017 Jan 10;7:40295. doi: 10.1038/srep40295. PubMed PMID: 28071739; PubMed Central PMCID: PMC5223127. Download PDF
2016
Brown EG, Keller BA, Lankford L, Pivetti CD, Hirose S, Farmer DL, Wang A. Age Does Matter: A Pilot Comparison of Placenta-Derived Stromal Cells for in utero Repair of Myelomeningocele Using a Lamb Model. Fetal Diagn Ther. 2016;39(3):179-85. doi: 10.1159/000433427. Epub 2015 Jul 7. PubMed PMID: 26159889. Download PDF
2015
Chen L, Ao Q, Sharma HS, Wang A, Feng S. Neurorestoratologic Strategies and Mechanisms in the Nervous System. Biomed Res Int. 2015;2015:163170. doi: 10.1155/2015/163170. Epub 2015 Sep 29. PubMed PMID: 26491655; PubMed Central PMCID: PMC4603317. Download PDF
Yu M, Sun ZJ, Li LT, Ge HY, Song CQ, Wang AJ. The beneficial effects of the herbal medicine Di-huang-yin-zi (DHYZ) on patients with ischemic stroke: A Randomized, Placebo controlled clinical study. Complement Ther Med. 2015 Aug;23(4):591-7. doi: 10.1016/j.ctim.2015.06.003. Epub 2015 Jun 19. PubMed PMID: 26275652. Download PDF
Wang A, Brown EG, Lankford L, Keller BA, Pivetti CD, Sitkin NA, Beattie MS, Bresnahan JC, Farmer DL. Placental mesenchymal stromal cells rescue ambulation in ovine myelomeningocele. Stem Cells Transl Med. 2015 Jun;4(6):659-69. doi: 10.5966/sctm.2014-0296. Epub 2015 Apr 24. PubMed PMID: 25911465; PubMed Central PMCID: PMC4449103. Download PDF
Brown EG, Keller BA, Pivetti CD, Sitkin NA, Wang A, Farmer DL, Bresnahan JC. Development of a locomotor rating scale for testing motor function in sheep. J Pediatr Surg. 2015 Apr;50(4):617-21. doi: 10.1016/j.jpedsurg.2015.01.002. Epub 2015 Jan 24. PubMed PMID: 25840074. Download PDF
Lankford L, Selby T, Becker J, Ryzhuk V, Long C, Farmer D, Wang A. Early gestation chorionic villi-derived stromal cells for fetal tissue engineering. World J Stem Cells. 2015 Jan 26;7(1):195-207. doi: 10.4252/wjsc.v7.i1.195. PubMed PMID: 25621120; PubMed Central PMCID: PMC4300931. Download PDF
Meierhenry J, Ryzhuk V, Miguelino M, Lankford L, Powell J, Farmer D, Wang A. Placenta as a Source of Stem Cells for Regenerative Medicine. Current Pathobiology Reports. 2015; 3(1):9-16. doi: 10.1007/s40139-015-0070-6.
2014
Xiang P, Wu KC, Zhu Y, Xiang L, Li C, Chen DL, Chen F, Xu G, Wang A, Li M, Jin ZB. A novel Bruch’s membrane-mimetic electrospun substrate scaffold for human retinal pigment epithelium cells. Biomaterials. 2014 Dec;35(37):9777-9788. doi: 10.1016/j.biomaterials.2014.08.040. Epub 2014 Sep 15. PubMed PMID: 25220295. Download PDF
Wei Y, Gong K, Ao Q, Wang A, Gong Y, Zuo H, Zhang Y, Wang J, Wang G. Lentiviral vectors enveloped with rabies virus glycoprotein can be used as a novel retrograde tracer to assess nerve recovery in rat sciatic nerve injury models. Cell Tissue Res. 2014 Feb;355(2):255-66. doi: 10.1007/s00441-013-1756-x. Epub 2013 Dec 11. PubMed PMID: 24326614. Download PDF
Brown EG, Saadai P, Pivetti CD, Beattie MS, Bresnahan JC, Wang A, Farmer DL. In utero repair of myelomeningocele with autologous amniotic membrane in the fetal lamb model. J Pediatr Surg. 2014 Jan;49(1):133-7; discussion 137-8. doi: 10.1016/j.jpedsurg.2013.09.043. Epub 2013 Oct 5. PubMed PMID: 24439597. Download PDF
2013
Xu W, Wang Y, Liu E, Sun Y, Luo Z, Xu Z, Liu W, Zhong L, Lv Y, Wang A, Tang Z, Li S, Yang L. Human iPSC-derived neural crest stem cells promote tendon repair in a rat patellar tendon window defect model. Tissue Eng Part A. 2013 Nov;19(21-22):2439-51. doi: 10.1089/ten.TEA.2012.0453. Epub 2013 Aug 9. PubMed PMID: 23815150; PubMed Central PMCID: PMC3807699. Download PDF
Lee BL, Tang Z, Wang A, Huang F, Yan Z, Wang D, Chu JS, Dixit N, Yang L, Li S. Synovial stem cells and their responses to the porosity of microfibrous scaffold. Acta Biomater. 2013 Jul;9(7):7264-75. doi: 10.1016/j.actbio.2013.03.009. Epub 2013 Mar 19. PubMed PMID: 23523935; PubMed Central PMCID: PMC3669641. Download PDF
Tang Z, Wang A, Wang D, Li S. Smooth muscle cells: to be or not to be? Response to Nguyen et Al. Circ Res. 2013 Jan 4;112(1):23-6. doi: 10.1161/CIRCRESAHA.112.281055. Epub 2012 Oct 23. PubMed PMID: 23093574. Download PDF
Saadai P, Wang A, Nout YS, Downing TL, Lofberg K, Beattie MS, Bresnahan JC, Li S, Farmer DL. Human induced pluripotent stem cell-derived neural crest stem cells integrate into the injured spinal cord in the fetal lamb model of myelomeningocele. J Pediatr Surg. 2013 Jan;48(1):158-63. doi: 10.1016/j.jpedsurg.2012.10.034. PubMed PMID: 23331809. Download PDF
2012
Yu J, Wang A, Tang Z, Henry J, Li-Ping Lee B, Zhu Y, Yuan F, Huang F, Li S. The effect of stromal cell-derived factor-1α/heparin coating of biodegradable vascular grafts on the recruitment of both endothelial and smooth muscle progenitor cells for accelerated regeneration. Biomaterials. 2012 Nov;33(32):8062-74. doi: 10.1016/j.biomaterials.2012.07.042. Epub 2012 Aug 11. PubMed PMID: 22884813; PubMed Central PMCID: PMC3488434. Download PDF
Downing TL, Wang A, Yan ZQ, Nout Y, Lee AL, Beattie MS, Bresnahan JC, Farmer DL, Li S. Drug-eluting microfibrous patches for the local delivery of rolipram in spinal cord repair. J Control Release. 2012 Aug 10;161(3):910-7. doi: 10.1016/j.jconrel.2012.05.034. Epub 2012 May 23. PubMed PMID: 22634093; PubMed Central PMCID: PMC3698241. Download PDF
Lee BL, Jeon H, Wang A, Yan Z, Yu J, Grigoropoulos C, Li S. Femtosecond laser ablation enhances cell infiltration into three-dimensional electrospun scaffolds. Acta Biomater. 2012 Jul;8(7):2648-58. doi: 10.1016/j.actbio.2012.04.023. Epub 2012 Apr 19. PubMed PMID: 22522128; PubMed Central PMCID: PMC3425609. Download PDF
Tang Z, Wang A, Yuan F, Yan Z, Liu B, Chu JS, Helms JA, Li S. Differentiation of multipotent vascular stem cells contributes to vascular diseases. Nat Commun. 2012 Jun 6;3:875. doi: 10.1038/ncomms1867. PubMed PMID: 22673902; PubMed Central PMCID: PMC3538044. Download PDF
2011
Saadai P, Nout YS, Encinas J, Wang A, Downing TL, Beattie MS, Bresnahan JC, Li S, Farmer DL. Prenatal repair of myelomeningocele with aligned nanofibrous scaffolds-a pilot study in sheep. J Pediatr Surg. 2011 Dec;46(12):2279-83. doi: 10.1016/j.jpedsurg.2011.09.014. PubMed PMID: 22152865. Download PDF
Hsu S, Chu JS, Chen FF, Wang A, Li S. Effects of Fluid Shear Stress on a Distinct Population of Vascular Smooth Muscle Cells. Cell Mol Bioeng. 2011 Dec;4(4):627-636. doi: 10.1007/s12195-011-0205-8. PubMed PMID: 22924082; PubMed Central PMCID: PMC3425612. Download PDF
Li X, Chu J, Wang A, Zhu Y, Chu WK, Yang L, Li S. Uniaxial mechanical strain modulates the differentiation of neural crest stem cells into smooth muscle lineage on micropatterned surfaces. PLoS One. 2011;6(10):e26029. doi: 10.1371/journal.pone.0026029. Epub 2011 Oct 7. PubMed PMID: 22016804; PubMed Central PMCID: PMC3189240. Download PDF
Wang A, Tang Z, Park IH, Zhu Y, Patel S, Daley GQ, Li S. Induced pluripotent stem cells for neural tissue engineering. Biomaterials. 2011 Aug;32(22):5023-32. doi: 10.1016/j.biomaterials.2011.03.070. Epub 2011 Apr 22. PubMed PMID: 21514663; PubMed Central PMCID: PMC3100451. Download PDF
Wei Y, Gong K, Zheng Z, Wang A, Ao Q, Gong Y, Zhang X. Chitosan/silk fibroin-based tissue-engineered graft seeded with adipose-derived stem cells enhances nerve regeneration in a rat model. J Mater Sci Mater Med. 2011 Aug;22(8):1947-64. doi: 10.1007/s10856-011-4370-z. Epub 2011 Jun 8. PubMed PMID: 21656031. Download PDF
Zhu Y, Wang A, Patel S, Kurpinski K, Diao E, Bao X, Kwong G, Young WL, Li S. Engineering bi-layer nanofibrous conduits for peripheral nerve regeneration. Tissue Eng Part C Methods. 2011 Jul;17(7):705-15. doi: 10.1089/ten.tec.2010.0565. Epub 2011 Apr 18. PubMed PMID: 21501089; PubMed Central PMCID: PMC3124110. Download PDF
Park JS, Chu JS, Tsou AD, Diop R, Tang Z, Wang A, Li S. The effect of matrix stiffness on the differentiation of mesenchymal stem cells in response to TGF-β. Biomaterials. 2011 Jun;32(16):3921-30. doi: 10.1016/j.biomaterials.2011.02.019. PubMed PMID: 21397942; PubMed Central PMCID: PMC3073995. Download PDF
2010
Wei Y, Gong K, Zheng Z, Liu L, Wang A, Zhang L, Ao Q, Gong Y, Zhang X. Schwann-like cell differentiation of rat adipose-derived stem cells by indirect co-culture with Schwann cells in vitro. Cell Prolif. 2010 Dec;43(6):606-16. doi: 10.1111/j.1365-2184.2010.00710.x. PubMed PMID: 21039999; PubMed Central PMCID: PMC6496385. Download PDF
Wang G, Ao Q, Gong K, Wang A, Zheng L, Gong Y, Zhang X. The effect of topology of chitosan biomaterials on the differentiation and proliferation of neural stem cells. Acta Biomater. 2010 Sep;6(9):3630-9. doi: 10.1016/j.actbio.2010.03.039. Epub 2010 Apr 3. PubMed PMID: 20371303. Download PDF
Lam HJ, Patel S, Wang A, Chu J, Li S. In vitro regulation of neural differentiation and axon growth by growth factors and bioactive nanofibers. Tissue Eng Part A. 2010 Aug;16(8):2641-8. doi: 10.1089/ten.TEA.2009.0414. PubMed PMID: 20367289; PubMed Central PMCID: PMC2947452. Download PDF
Zhu Y, Wang A, Shen W, Patel S, Zhang R, Young W, Li S. Nanofibrous Patches for Spinal Cord Regeneration. Adv Funct Mater. 2010 May 10;20(9):1433-1440. doi: 10.1002/adfm.200901889. Epub 2010 Mar 17. PubMed PMID: 23378825; PubMed Central PMCID: PMC3558949. Download PDF
2009
Wei Y, Zhou J, Zheng Z, Wang A, Ao Q, Gong Y, Zhang X. An improved method for isolating Schwann cells from postnatal rat sciatic nerves. Cell Tissue Res. 2009 Sep;337(3):361-9. doi: 10.1007/s00441-009-0836-4. Epub 2009 Jul 29. PubMed PMID: 19639342. Download PDF
Zheng Z, Zhang L, Kong L, Wang A, Gong Y, Zhang X. The behavior of MC3T3-E1 cells on chitosan/poly-L-lysine composite films: effect of nanotopography, surface chemistry, and wettability. J Biomed Mater Res A. 2009 May;89(2):453-65. doi: 10.1002/jbm.a.31979. PubMed PMID: 18431777. Download PDF
Zheng Z, Wei Y, Wang G, Wang A, Ao Q, Zhang X. Surface Properties of Chitosan Films Modified with Polycations and Their Effects on the Behavior of PC12 Cells. Journal of Bioactive and Compatible Polymers. 2009; 24(1):63-82. doi: 10.1177/0883911508099653. Download PDF
2008
Zhou F, Zhang L, Wang A, Song B, Gong K, Zhang L, Hu M, Zhang X, Zhao N, Gong Y. The association of GSK3 beta with E2F1 facilitates nerve growth factor-induced neural cell differentiation. J Biol Chem. 2008 May 23;283(21):14506-15. doi: 10.1074/jbc.M706136200. Epub 2008 Mar 26. PubMed PMID: 18367454. Download PDF
Zhou F, Zhang L, Gong K, Lu G, Sheng B, Wang A, Zhao N, Zhang X, Gong Y. LEF-1 activates the transcription of E2F1. Biochem Biophys Res Commun. 2008 Jan 4;365(1):149-53. doi: 10.1016/j.bbrc.2007.10.138. Epub 2007 Oct 31. PubMed PMID: 17980157. Download PDF
2007
Wang A, Ao Q, Wei Y, Gong K, Liu X, Zhao N, Gong Y, Zhang X. Physical properties and biocompatibility of a porous chitosan-based fiber-reinforced conduit for nerve regeneration. Biotechnol Lett. 2007 Nov;29(11):1697-702. doi: 10.1007/s10529-007-9460-0. Epub 2007 Jul 13. PubMed PMID: 17628751. Download PDF
Kong L, Ao Q, Wang A, Gong K, Wang X, Lu G, Gong Y, Zhao N, Zhang X. Preparation and characterization of a multilayer biomimetic scaffold for bone tissue engineering. J Biomater Appl. 2007 Nov;22(3):223-39. doi: 10.1177/0885328206073706. Epub 2007 Jan 25. PubMed PMID: 17255157. Download PDF
Ao Q, Wang AJ, Chen GQ, Wang SJ, Zuo HC, Zhang XF. Combined transplantation of neural stem cells and olfactory ensheathing cells for the repair of spinal cord injuries. Med Hypotheses. 2007;69(6):1234-7. doi: 10.1016/j.mehy.2007.04.011. Epub 2007 Jun 4. PubMed PMID: 17548168. Download PDF
He Q, Ao Q, Wang A, Gong Y, Zhao N, Zhang X. In Vitro Cytotoxicity and Protein Drug Release Properties of Chitosan/Heparin Microspheres. Tsinghua Science and Technology. 2007; 12(4):361-365. doi: 10.1007/s40139-015-0070-6. Download PDF
2006
Ao Q, Sun XH, Wang AJ, Fu PF, Gong K, Zuo HC, Gong YD, Zhang XF. Protective effects of extract of Ginkgo biloba (EGb 761) on nerve cells after spinal cord injury in rats. Spinal Cord. 2006 Nov;44(11):662-7. doi: 10.1038/sj.sc.3101900. Epub 2006 Jan 17. PubMed PMID: 16415923. Download PDF
Wang A, Ao Q, Cao W, Yu M, He Q, Kong L, Zhang L, Gong Y, Zhang X. Porous chitosan tubular scaffolds with knitted outer wall and controllable inner structure for nerve tissue engineering. J Biomed Mater Res A. 2006 Oct;79(1):36-46. doi: 10.1002/jbm.a.30683. PubMed PMID: 16758450. Download PDF
Qi H, Hu P, Xu J, Wang A. Encapsulation of drug reservoirs in fibers by emulsion electrospinning: morphology characterization and preliminary release assessment. Biomacromolecules. 2006 Aug;7(8):2327-30. doi: 10.1021/bm060264z. PubMed PMID: 16903678. Download PDF
Zhang L, Ao Q, Wang A, Lu G, Kong L, Gong Y, Zhao N, Zhang X. A sandwich tubular scaffold derived from chitosan for blood vessel tissue engineering. J Biomed Mater Res A. 2006 May;77(2):277-84. doi: 10.1002/jbm.a.30614. PubMed PMID: 16400655. Download PDF
Ao Q, Wang A, Cao W, Zhang L, Kong L, He Q, Gong Y, Zhang X. Manufacture of multimicrotubule chitosan nerve conduits with novel molds and characterization in vitro. J Biomed Mater Res A. 2006 Apr;77(1):11-8. doi: 10.1002/jbm.a.30593. PubMed PMID: 16345091. Download PDF
Wang A, Ao Q, He Q, Gong X, Gong K, Gong Y, Zhao N, Zhang X. Neural Stem Cell Affinity of Chitosan and Feasibility of Chitosan-based Porous Conduits as Scaffolds for Nerve Tissue Engineering. Tsinghua Science and Technology. 2006; 11(4):415-420. doi: 10.1177/0883911508099653. Download PDF
2005
Ao Q, Wang A, Cao W, Zhao C, Gong Y, Zhao N, Zhang X. Preparation of Porous Multi-channeled Chitosan Conduits for Nerve Tissue Engineering. Key Engineering Materials. 2005; 288-289:27-30. doi: 10.4028/www.scientific.net/KEM.288-289.27. Download PDF
Cao W, Wang A, Jing D, Gong Y, Zhao N, Zhang X. Novel biodegradable films and scaffolds of chitosan blended with poly(3-hydroxybutyrate). J Biomater Sci Polym Ed. 2005;16(11):1379-94. doi: 10.1163/156856205774472308. PubMed PMID: 16370239.
Ao Q, Wang A, Cao W, Zhao C, Gong Y, Zhao N, Zhang X. Fabrication and Characterization of Chitosan Nerve Conduits with Microtubular Architecture. Tsinghua Science and Technology. 2005; 10(4):435-438. doi: 10.4028/www.scientific.net/KEM.288-289.27. Download PDF
Wang A, Ao Q, Cao W, Zhao C, Gong Y, Zhao N, Zhang X. Fiber-based Chitosan Tubular Scaffolds for Soft Tissue Engineering: Fabrication and in vitro Evaluation. Tsinghua Science and Technology. 2005; 10(4):449-453. doi: 10.1016/S1007-0214(05)70099-7.