Members
Aijun Wang
Associate Professor
Associate Investigator
Co-Director, Surgical Bioengineering Laboratory Dept. Of Surgery
University of California, Davis
4625 2nd Ave., Research II, Room 3005, Sacramento, CA 95817
(916) 703-0422
aawang (at) ucdavis.edu
Education
- Department of Surgery, University of California, Davis
- Department of Biomedical Engineering, University of California, Davis
- Ph.D. Biomaterials and Tissue engineering, Tsinghua University, Beijing, China
- Post-Doc, Bioengineering, University of California Berkeley
- Post-Doc, Stem cell engineering, Berkeley Stem Cell Center, California Institute for Regenerative Medicine (CIRM)
Research Interests
Stem cell engineering, biomaterial engineering, tissue engineering, fetal tissue engineering, fetal treatment of birth defects, vascular and neural tissue regeneration, wound healing
Current Research
Dr. Wang’s research focuses on developing novel technologies that combine stem cell engineering and biomaterial engineering to promote tissue regeneration. The Wang Group focuses on the engineering and development of stem cells, stem cell-derived exosomes and biomaterial-based scaffolds for the treatment of a variety of surgical diseases. Projects include engineering stem cells and stem cell-derived exosomes for improved therapeutic functions and targeted delivery; engineering biomaterial scaffolds by using instructive ligands for stem cell culture, delivery and recruitment; evaluating stem cell and biomaterial products in experimental animal models and naturally occurring disease models.
Please see: Dr. Wang’s laboratory website for more information.
Noteworthy Publications
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| Engineering Extracellular Vesicles as Nanotherapeutics for Regenerative Medicine. 2019, Biomolecules. 2019 Dec 28;10(1). PMID: 31905611. DOI: 10.3390/biom10010048. | Lalithasri Ramasubramanian, Priyadarsini Kumar, Aijun Wang. |
2019 |
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| Development of Injectable Amniotic Membrane Matrix for Postmyocardial Infarction Tissue Repair. Advanced Healthcare | Jeffrey J. D. Henry, Lawrence Delrosario, Jun Fang, Sze Yue Wong, Qizhi Fang, Richard Sievers, Surya Kotha, Aijun Wang, Diana Farmer, Praneeth Janaswamy, Randall J. Lee, Song Li. |
2019 |
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| Long Noncoding RNA-dependent Regulation of Vascular Smooth Muscle Cell Proliferation and Migration in Hypertension. The International Journal of Biochemistry & Cell Biology, 2019 Nov; 16:105653. | Juanjuan Tan, Yilin Xie, Aihong Yao, Yingchun Qin, Lei Li, Li Shen, Xiaoqin Zhang, Chunfang Xu, Xuesong Jiang, Aijun Wang, Zhiqiang Yan. |
2019 |
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| Neuroprotective Placental Mesenchymal Stem Cell-Derived Extracellular Vesicles Promote Myelin Regeneration in an Animal Model of Multiple Sclerosis. Cells, 2019, 8(12), 1497. PMID: 31771176. DOI: 10.3390/cells8121497 | Kaitlin Clark, Sheng Zhang, Sylvain Barthe, Priyadarsini Kumar, Christopher Pivetti, Nicole Kreutzberg, Camille Reed, Yan Wang, Zachary Paxton, Diana Farmer, Fuzheng Guo, Aijun Wang. |
2019 |
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| Hypoxic Preconditioning Enhances Survival and Proangiogenic Capacity of Human First Trimester Chorionic Villus-Derived Mesenchymal Stem Cells for Fetal Tissue Engineering. Stem Cells International. 2019, Nov 12; 2019:9695239. PMID: 31781252. PMCID: PMC6874947. DOI: 10.1155/2019/9695239 | Dake Hao, Chuanchao He, Bowen Ma, Lee Lankford, Lizette Reynaga, Diana L. Farmer, Fuzheng Guo, Aijun Wang. |
2019 |
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| Developing regenerative treatments for developmental defects, injuries, and diseases using extracellular matrix collagen-targeting peptides. International Journal of Molecular Sciences. 2019, 20(17), 4072. PMID: 31438477. DOI: 10.3390/ijms20174072. | Leora Goldbloom-Helzner, Dake Hao, Aijun Wang. |
2019 |
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| LncRNA TUG1 regulates FGF1 to enhance endothelial differentiation of adipose‐derived stem cells by sponging miR-143. J Cell Biochem. 2019 Jul 1. [Epub ahead of print]. PMID: 31264280. DOI: 10.1002/jcb.29232 | Ya-Nan Xue, Yu Yan, Zi-Zi Chen, Jia Chen, Feng-Jie Tang, Hui-Qing Xie, Shijie Tang, Ke Cao, Xiao Zhou, Aijun Wang, Jianda Zhou. |
2019 |
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| Studies on the treatment of melanoma with folate acid conjugated dextran and lauryl alcohol loaded with IMD0354. Onco Targets Ther. 2019 Jun; 12: 4655–4663. PMID: 31354298. PMCID: PMC6585409. DOI: 10.2147/OTT.S207685 | Can Liu, Wei Chen, Zizi Chen, Yu Yan, Qing Wang, Huiqing Xie, Xiang Chen, Aijun Wang, Shijie Tang, Jianda Zhou. |
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| Matrix Stiffness Modulates the Differentiation of Neural Crest Stem Cells In Vitro and In Vivo. Journal of Cellular Physiology. 2019 May; 234(5):7569-7578. | Yiqian Zhu, Xian Li, Randall Raphael R. Janairo, George Kwong, Anchi D. Tsou, Julia S. Chu, Aijun Wang, Song Li. |
2019 |
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| Neuroprotective Effect of Placenta-derived Mesenchymal Stromal Cells: Role of Exosomes. The FASEB Journal. 2019 May; 33(5):5836-5849. PMID: 30753093. DOI: 10.1096/fj.201800972R | Priyadarsini Kumar, James C. Becker, Kewa Gao, Randy P. Carney, Lee Lankford, Benjamin A. Keller, Kyle Herout, Kit S. Lam, Diana Farmer, Aijun Wang. |
2019 |
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| Spinal Angulation: A Limitation of the Fetal Lamb Model of Myelomeningocele. Fetal Diagn Ther. 2019 Apr; 10:1-9. PMID: 30970373. DOI: 10.1159/000496201 | Melissa Vanover, Christopher Pivetti, Laura Galganski, Priyadarsini Kumar, Lee Lankford, Douglas Rowland, Zachary Paxton, Bailey Deal, Aijun Wang, Diana Farmer. |
2019 |
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| Overexpression of long non-coding RNA NORAD promotes invasion and migration in malignant melanoma via regulating the MIR-205-EGLN2 pathway. Cancer Medicine. 2019 Apr; 8(4):1744-1754. PMID: 30843652. DOI: https://doi.org/10.1002/cam4.2046 | Yong Chen, Ke Cao, Jingjing Li, Aijun Wang, Lichun Sun, Jintian Tang, Wei Xiong, Xiao Zhou, Xiang Chen, Jianda Zhou, Yan Liu. |
2019 |
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| Auricle shaping using 3D printing and autologous diced cartilage. Laryngoscope. 2019 Nov; 129(11):2467-2474. PMID: 30843613. PMCID: PMC6850318. DOI: 10.1002/lary.27752 | Junlin Liao, Yong Chen, Jia Chen, Bin He, Li Qian, Jiaqin Xu, Aijun Wang, Qingfeng Li, Hongju Xie, Jianda Zhou. |
2019 |
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| Effect and Mechanism of Ganoderma lucidum Polysaccharides on Human Fibroblasts and Skin Wound Healing in Mice. Chinese Journal of Integrative Medicine. 2019 Mar;25(3):203-209. PMID: 30552545. DOI: 10.1007/s11655-018-3060-9 | Feng Hu, Yu Yan, Chu-wang Wang, Yu Liu, Jing-jing Wang, Fang Zhou, Qing-hai Zeng, Xiao Zhou, Jia Chen, Aijun Wang, Jianda Zhou. |
2019 |
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| Blockage of transferred exosome-shuttled miR494 inhibits melanoma growth and metastasis. Journal of Cellular Physiology. 2019 Feb 5. doi: 10.1002/jcp.28234. [Epub ahead of print] PMID: 30723916. DOI: 10.1002/jcp.28234 | Jingjing Li, Jia Chen, Shaohua Wang, Ping Li, Changli Zheng, Xiao Zhou, Yongguang Tao, Xiang Chen, Lichun Sun, Aijun Wang, Ke Cao, Shijie Tang, Jianda Zhou. |
2019 |
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| Cell-based In Utero Therapies for Spina Bifida: Implications for Neural Regeneration. Neural Regeneration Research. 2019, 14(2):260-261. PMID: 30531007. PMCID: PMC6301160. DOI: 10.4103/1673-5374.244786 | Connor Long, Lee Lankford, Aijun Wang. |
2019 |
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| Potential long-term treatment of hemophilia A by neonatal co-transplantation of cord blood derived endothelial colony-forming cells and placental mesenchymal stromal cells. Stem Cell Research & Therapy. 2019 Jan 22;10(1):34. PMID: 30670078. PMCID: PMC6341603. DOI: 10.1186/s13287-019-1138-8 | Kewa Gao, Priyadarsini Kumar, Elizabeth Cortez-Toledo, Dake Hao, Lizette Reynaga, Melanie Rose, Chuwang Wang, Diana Farmer, Jan Nolta, Jianda Zhou, Ping Zhou, Aijun Wang |
2019 |
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| ANKHD1 is required for SMYD3 to promote tumor metastasis in hepatocellular carcinoma. Journal of Experimental & Clinical Cancer Research. 2019 Jan 15;38(1):18. #Co-corresponding author. PMID: 30646949. PMCID: PMC6332640. DOI: https://doi.org/10.1186/s13046-018-1011-0 | Zhenyu Zhou, Hai Jiang, Kangsheng Tu, Wei Yu, Jianlong Zhang, Zhigang Hu, Heyun Zhang, Dake Hao, Pinbo Huang, Jie Wang, Aijun Wang#, Zhiyu Xiao#, Chuanchao He#. |
2019 |
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| OTUB2 Promotes Cancer Metastasis via Hippo-Independent Activation of YAP and TAZ. Molecular Cell. 2019 Jan 3;73(1):7-21.e7. PMID: 30472188. DOI: 10.1016/j.molcel.2018.10.030 | Zhengkui Zhang, Jinjin Du, Shuai Wang, Li Shao, Ke Jin, Fang Li, Bajin Wei, Wei Ding, Peifen Fu, Hansvan Dam, Aijun Wang, Jin Jin, Chen Ding, BingYang, Min Zheng, Xin-Hua Feng, Kun-Liang Guan, Long Zhang. |
2019 |
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| High Density Placental Mesenchymal Stromal Cells Provide Neuronal Preservation and Improve Motor Function Following In Utero Treatment of Ovine Myelomeningocele. The Journal of Pediatric Surgery. 2019 Jan;54(1):75-79. PMID: 30529115. PMCID: PMC6339576. DOI: https://doi.org/10.1016/j.jpedsurg.2018.10.032 | Melissa Vanover, Christopher Pivetti, Lee Lankford, Priyadarsini Kumar, Laura Galganski, Sandra Kabagambe, Benjamin Keller, James Becker, Y. Julia Chen, Karen Chung, Chelsey Lee, Zachary Paxton, Bailey Deal, Laura Goodman, Jamie Anderson, Guy Jensen, Aijun Wang, Diana Farmer. |
2019 |
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| In Utero Treatment of Myelomeningocele with Placental Mesenchymal Stromal Cells Rescues Ambulation in the Ovine Model – Selection of an Optimal Cell Line in Preparation for Clinical Trials. The Journal of Pediatric Surgery. 2019, Oct 21. pii: S0022-3468(19)30681-5. [Epub ahead of print]. PMID: 31672407. DOI: 10.1016/j.jpedsurg.2019.09.029 | Laura Galganski, Priyadarsini Kumar, Melissa Vanover, Christopher Pivetti, Jamie Anderson, Lee Lankford, Zachary Paxton, Karen Chung, Chelsey Lee, Hegazi MS, Kaeli Yamashiro, Aijun Wang, Diana Farmer. |
2019 |
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| The stem cell factor Sox2 is a positive timer of oligodendrocyte development in the postnatal murine spinal cord. Molecular Neurobiology. 2018 Dec; 55(12):9001-9015. PMID: 29623612. PMCID: PMC6173662. DOI: 10.1007/s12035-018-1035-7 | Sheng Zhang, Abeer Rasai, Yan Wang, Jie Xu, Peter Bannerman, Daffcar Erol, Danayit Tsegaye, Aijun Wang, Athena Soulika, Xiangjiang Zhan, Fuzheng Guo. |
2018 |
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| Engineering mesenchymal stem cells to improve their exosome efficacy and yield for cell-free therapy. Journal of Extracellular Vesicles. 2018, Sep 26; 7(1):1522236. PMID: 30275938. PMCID: PMC6161586. DOI: 10.1080/20013078.2018.1522236 | Jennifer Phan, Priyadarsini Kumar, Dake Hao, Kewa Gao, Diana Farmer, Aijun Wang. |
2018 |
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| Matrix Stiffness Modulates the Differentiation of Neural Crest Stem Cells In Vitro and In Vivo. Journal of Cellular Physiology. 2018. | Yiqian Zhu, Xian Li, Randall Raphael R. Janairo, George Kwong, Anchi D. Tsou, Julia S. Chu, Aijun Wang, Song Li. |
2018 |
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| Mesenchymal Stem Cell-Derived Exosomes: Potential Approaches to Improve Efficacy and Yield for Cell-Free Therapy. Journal of Extracellular Vesicles. 2018, 7:1, 1522236. DOI: https://doi.org/10.1080/20013078.2018.1522236 | Jennifer Phan, Priyadarsini Kumar, Dake Hao, Kewa Gao, Diana Farmer, Aijun Wang. |
2018 |
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| The stem cell factor Sox2 is a positive timer of oligodendrocyte development in the postnatal murine spinal cord. Molecular Neurobiology. 2018. Accepted. | Sheng Zhang, Abeer Rasai, Yan Wang, Jie Xu, Peter Bannerman, Daffcar Erol, Danayit Tsegaye, Aijun Wang, Athena Soulika, Xiangjiang Zhan, Fuzheng Guo. |
2018 |
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| In Utero Transplantation of Placenta-derived Mesenchymal Stromal Cells for Potential Application in Hemophilia A Therapy. Cell Transplantation. 2018 Jan;27(1):130-139. PMID: 29562772. DOI: 10.1177/0963689717728937 | Priyadarsini Kumar, Kewa Gao, Chuwang Wang, Christopher Pivetti, Lee Lankford, Diana Farmer, Aijun Wang. |
2018 |
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| Human amnion extracellular matrix derived bioactive hydrogel for cell delivery and tissue engineering. Materials Science & Engineering C. 2018 Apr 1;85:191-202. PMID: 29407148. DOI: 10.1016/j.msec.2017.12.026 | Volodymyr Ryzhuk, Xu-xin Zeng, Xijun Wang, Veniamin Melnychuk, Lee Lankford, Diana Farmer, Aijun Wang. |
2018 |
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| Differentially expressed circRNAs in melanocytes and melanoma cells and their effect on cell proliferation and invasion. Oncology Reports. 2018 Apr;39(4):1813-1824. PMID: 29436673. DOI: 10.3892/or.2018.6263 | Qi Wang, Jia Chen, Aijun Wang, Lichun Sun, Li Qian, Xiao Zhou, Yu Liu, Shijie Tang, Xiang Chen, Yan Cheng, Ke Cao, Jianda Zhou. |
2018 |
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| Sox2 is Essential for Oligodendroglial Proliferation and Differentiation During Postnatal Brain Myelination and CNS Remyelination. The Journal of Neuroscience. 2018 Feb 14;38(7):1802-1820. PMID: 29335358. PMCID: PMC5815459. DOI: 10.1523/JNEUROSCI.1291-17.2018 | Sheng Zhang, Xiaoqing Zhu, Xuehong Gui, Christopher Croteau, Lanying Song, Jie Xu, Aijun Wang, Peter Bannermann, Fuzheng Guo. |
2018 |
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| Stem Cells in Vascular Remodeling. Theranostics. 2018; 8(3):815-829. PMID: 29344309. PMCID: PMC5771096. DOI: 10.7150/thno.19577 | Dong Wang, LeeAnn K. Li, Tiffany Dai, Aijun Wang, Song Li. |
2018 |
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| Isolation and Characterization of Canine Placenta-derived Mesenchymal Stromal Cells for the Treatment of Neurological Disorders in Dogs. Cytometry Part A. 2018; 93(1):82-92. PMID: 28715613. DOI: 10.1002/cyto.a.23171 | Connor Long, Lee Lankford, Priyadarsini Kumar, Robert Grahn, Dori L. Borjesson, Diana Farmer, Aijun Wang. |
2018 |
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| Fetal Surgical Repair with Placenta-derived Mesenchymal Stromal Cell Engineered Patch in a Rodent Model of Myelomeningocele. The Journal of Pediatric Surgery. 2018, 53:183-188. DOI: https://doi.org/10.1016/j.jpedsurg.2017.10.040 | Y. Julia Chen, Karen Chung, Christopher Pivetti, Lee Lankford, Sandra Kabagambe, Melissa Vanover, James Becker, Chelsey Lee, Josephine Tsang, Aijun Wang, Diana Farmer. |
2018 |
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| Placental Mesenchymal Stromal Cells Seeded on Clinical Grade Extracellular Matrix Improve Ambulation in Ovine Myelomeningocele. The Journal of Pediatric Surgery. 2018, 53:178-182. DOI: https://doi.org/10.1016/j.jpedsurg.2017.10.032 | Sandra Kabagambe, Benjamin Keller, James Becker, Laura Goodman, Christopher Pivetti, Lee Lankford, Karen Chung, Chelsey Lee, Y. Julia Chen, Priyadarsini Kumar, Melissa Vanover, Aijun Wang, Diana Farmer. |
2018 |
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| Paxillin facilitates timely neurite initiation on soft-substrate environments by interacting with the endocytic machinery. eLife. 2017; 6:e31101. PMID:29271742. PMCID: PMC5768420. DOI: 10.7554/eLife.31101 | Ting-Ya Chang, Chen Chen, Ya-Chu Chang, Chi-Huan Lu, Min Lee, Shao-Tzu Lu, De-Yao Wang, Aijun Wang, Chin-Lin Guo, Pei-Lin Cheng. |
2017 |
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| The Differentiation Stage of Transplanted Stem Cells Modulates Nerve Regeneration. Scientific Reports. 2017; 7(1):17401. PMID: 29234013. PMCID: PMC5727226. DOI: 10.1038/s41598-017-17043-4 | Ching-Wen Huang, Wen-Chin Huang, Xuefeng Qiu, Flavia Fernandes Ferreira da Silva, Aijun Wang, Shyam Patel, Leon J. Nesti, Mu-Ming Poo, Song Li. |
2017 |
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| Isolation of a Myogenic Progenitor Cell Population from Human Placenta: a pilot study. The Journal of Pediatric Surgery. 2017; 52(12):2078-2082. PMID: 28964407. DOI: 10.1016/j.jpedsurg.2017.08.025 | Sandra Kabagambe, Lee Lankford, Priyadarsini Kumar, Y. Julia Chen, Kyle Herout, Chelsey Lee, Rebecca Stark, Diana Farmer, Aijun Wang. |
2017 |
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| Potential clinical applications of placental stem cells for use in fetal therapy of birth defects. Placenta. 2017, 59:107-112. PMID: 28651900. DOI: 10.1016/j.placenta.2017.05.010 | Melissa Vanover, Aijun Wang, Diana Farmer. |
2017 |
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| microRNA-33a-5p increases radiosensitivity by modulating glycolysis in melanoma cells. Oncotarget. 2017; 8:83660-83672. DOI: 10.18632/oncotarget.19014 | Ke Cao, Jingjing Li, Jia Chen, Li Qian, Aijun Wang, Xiang Chen, Wei Xiong, jingtian tang, Shijie Tang, Yong Chen, Yao Chen, Yan Cheng, Jianda Zhou. |
2017 |
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| Sox10+ cells contribute to vascular development in multiple organs. Arteriosclerosis, Thrombosis, and Vascular Biology. 2017 Sep;37(9):1727-1731. PMID: 28751573 PMCID: PMC5572822. DOI: https://doi.org/10.1161/ATVBAHA.117.309774 | Dong Wang, Fan Wu, Haoyong Yuan, Aijun Wang, Gyeong Jin Kang, Tan Truong, Lu Chen, Andrew S. McCallion, Xiaohua Gong, Song Li. |
2017 |
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| Viability and Biomechanics of Diced Cartilage Blended with Platelet-Rich Plasma and Wrapped with Poly (Lactic-Co-Glycolic) Acid Membrane. The Journal of Craniofacial Surgery. 2017; 28(6):1418-1424. PMID: 28692513. DOI: 10.1097/SCS.0000000000003739 | Junlin Liao, Jia Chen, Bin He, Yong Chen, Jiaqun Xu, Hongju Xie, Feng Hu, Aijun Wang, Chengqun Luo, Qingfeng Li, Jianda Zhou. |
2017 |
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| Effect of 2-octylcyanoacrylate on placenta derived mesenchymal stromal cells on extracellular matrix. Placenta. 2017 Apr 2. pii: S0143-4004(17)30222-9. PMID: 28465002. DOI: 10.1016/j.placenta.2017.03.022 | Y. Julia Chen, Lee Lankford, Sandra Kabagambe, Zoe Saenz, Priyadarsini Kumar, Diana Farmer, Aijun Wang. |
2017 |
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| Engineering the mechanical and biological properties of nanofibrous vascular grafts for in situ vascular tissue engineering. Biofabrication. 2017; 9(3):035007. PMID: 28817384. PMCID: PMC5847368. DOI: 10.1088/1758-5090/aa834b | Jeffrey Henry, Jian Yu, Aijun Wang, Randall Lee, Jun Fang, Song Li. |
2017 |
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| Manufacture and preparation of human placenta-derived mesenchymal stromal cells for local tissue delivery. Cytotherapy. 2017 Jun; 19(6):680-688. PMID: 28438482. DOI: 10.1016/j.jcyt.2017.03.003 | Lee Lankford, Y. Julia Chen, Zoe Saenz, Priyadarsini Kumar, Connor Long, Diana Farmer, Aijun Wang. |
2017 |
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| Discovery and characterization of a potent and specific peptide ligand targeting endothelial progenitor cells and endothelial cells for tissue regeneration. ACS Chem. Biol. 2017, 12 (4), 1075–1086. PMID: 28195700. DOI: 10.1021/acschembio.7b00118 | Dake Hao, Wenwu Xiao, Ruiwu Liu, Priyadarsini Kumar, Yuanpei Li, Ping Zhou, Fuzheng Guo, Diana L Farmer, Kit S. Lam, Fengshan Wang, Aijun Wang. |
2017 |
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| Highly Efficient Differentiation of Endothelial Cells from Pluripotent Stem Cells Requires the MAPK and the PI3K Pathways. Stem Cells. 2017. In press. DOI: 10.1002/stem.2577 | Aja Harding, Elizabeth Cortez-Toledo, Nataly Magner, Julie Beegle, Dane Coleal-Bergum, Dake Hao, Aijun Wang, Jan Nolta, Ping Zhou. |
2017 |
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| Sox10+ adult stem cells contribute to biomaterial encapsulation and microvascularization. Scientific Reports. 2017 Jan 10;7:40295. PMCID: PMC5223127. DOI: 10.1038/srep40295 | Dong Wang/Aijun Wang (Co-first author), Fan Wu, Xuefeng Qiu, Ye Li, Julia Chu, WC Huang, Kang Xu, Xiaohua Gong, Song Li. |
2017 |
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| Age Does Matter: A Pilot Comparison of Placenta-Derived Stromal Cells for in Utero Repair of Myelomeningocele Using a Lamb Model. Fetal Diagnosis and Therapy. 2016;39(3):179-85. PMID: 26159889 DOI: 10.1159/000433427 | Erin G. Brown, Benjamin A. Keller, Lee Lankford, Christopher D. Pivetti, Shin Hirose, Diana L. Farmer, Aijun Wang. |
2016 |
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| Editorial: Neurorestoratologic Strategies and Mechanisms in the Nervous System. BioMed Research International. 2015:163170. PMID: 26491655. PMCID: PMC4603317 DOI: 10.1155/2015/163170 | Lin Chen, Qiang Ao, Hari Shanker Sharma, Aijun Wang, Shiqing Feng. |
2015 |
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| The beneficial effects of the herbal medicine Di-huang-yin-zi (DHYZ) on patients with ischemic stroke: A randomized, placebo controlled clinical study. Complementary Therapies in Medicine, 2015; 23(4): 591–597. PMID: 26275652. DOI: 10.1016/j.ctim.2015.06.003 | Mei Yu, Zhi-Jun Sun, Lian-Tao Li, Hong-You Ge, Chang-Qin Song, Aijun Wang. |
2015 |
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| Placental Mesenchymal Stromal Cells Rescue Ambulation in Ovine Myelomeningocele. Stem Cells Translational Medicine. 2015 Jun; 4(6):659-69. #Corresponding author. PMID: 25911465 PMCID: PMC4449103 DOI: 10.5966/sctm.2014-0296 | Aijun Wang, Erin G. Brown, Benjamin A. Keller, Christopher D. Pivetti, Nicole A. Sitkin, Michael S. Beattie, Jacqueline C. Bresnahan, Diana L. Farmer. |
2015 |
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| Development of a Locomotor Rating Scale for Testing Motor Function in Sheep. The Journal of Pediatric Surgery. 2015 Apr;50(4):617-21. PMID: 25840074. DOI: 10.1016/j.jpedsurg.2015.01.002 | Erin G. Brown, Benjamin A. Keller, Christopher D. Pivetti, Nicole A. Sitkin, Aijun Wang, Diana L. Farmer, Jacqueline C. Bresnahan. |
2015 |
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| Placenta as a Source of Stem Cells for Regenerative Medicine. Current Pathobiology Reports. 2015, March; 3(1): 9-16. DOI: 10.1007/s40139-015-0070-6 | Jason A. Meierhenry, Volodymyr Ryzhuk, Maricel G. Miguelino, Lee Lankford, Jerry S. Powell, Diana Farmer, Aijun Wang. |
2015 |
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| Early Gestation Chorionic Villi-derived Stromal Cells for Fetal Tissue Engineering. World Journal of Stem Cells. 2015 Jan; 7(1): 195-207. PMCID: PMC4300931 DOI: 10.4252/wjsc.v7.i1.195 | Lee Lankford, Taryn Selby, James Becker, Volodymyr Ryzhuk, Connor Long, Diana Farmer, Aijun Wang. |
2015 |
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| A novel Bruch’s membrane-mimetic electrospun substrate scaffold for human retinal pigment epithelium cells. Biomaterials 2014 Dec;35(37):9777-88. PMID: 25220295. DOI: 10.1016/j.biomaterials.2014.08.040 | Ping Xiang, Kun-Chao Wu, Ying Zhu, Lue Xiang, Chong Li, Deng-Long Chen, Feng Chen, Guotong Xu, Aijun Wang, Min Li, Zi-Bing Jin. |
2014 |
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| Lentiviral vectors enveloped with rabies virus glycoprotein can be used as a novel retrograde tracer to assess nerve recovery in rat sciatic nerve injury models. Cell and Tissue Research. 2014 Feb; 355(2):255-66. PMID: 24326614. DOI: 10.1007/s00441-013-1756-x | Yujun Wei, Kai Gong, Qiang Ao, Aijun Wang, Yandao Gong, Huancong Zuo, Yuqi Zhang, James Wang, Guihuai Wang. |
2014 |
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| In utero repair of myelomeningocele with autologous amniotic membrane in the fetal lamb model. The Journal of Pediatric Surgery. 2014 Jan; 49(1):133-7; discussion 137-8. PMID: 24439597. DOI: 10.1016/j.jpedsurg.2013.09.043 | Erin Brown, Payam Saadai, Christopher Pivetti, Michael Beattie, Jacqueline Bresnahan, Aijun Wang, Diana Farmer. |
2014 |
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| Human iPSC-derived Neural Crest Stem Cells Promote Tendon Repair in a Rat Patellar Tendon Window Defect Model. Tissue Eng Part A. 2013 Jul; 19(21-22): 2439-2451. PMID: 23815150. PMCID: PMC3807699. DOI: 10.1089/ten.TEA.2012.0453 | Wei Xu, Yequan Wang, Erfu Liu, Yanjun Sun, Ziwei Luo, Zhiling Xu, Wanqian Liu, Li Zhong, Yonggang Lv, Aijun Wang, Zhenyu Tang, Song Li, Li Yang. |
2013 |
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| Synovial stem cells and their responses to the porosity of microfibrous scaffold. Acta Biomaterialia. 2013 Jul; 9(7):7264-75. PMID: 23523935. PMCID: PMC3669641. DOI: 10.1016/j.actbio.2013.03.009 | Benjamin Lee, Zhenyu Tang, Aijun Wang, Fang Huang, Zhiqiang Yan, Dong Wang, Julia Chu, Li Yang, Song Li. |
2013 |
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| Vascular Smooth Muscle Cells: To Be or Not To Be? Circulation Research. 2013 Jan;112(1):23-6. PMID: 23093574. DOI: 10.1161/CIRCRESAHA.112.281055 | Zhenyu Tang, Aijun Wang, Dong Wang, Song Li. |
2013 |
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| Human Induced Pluripotent Stem Cell-derived Neural Crest Stem Cells Integrate into the Injured Spinal Cord in the Fetal Lamb Model of Myelomeningocele. The Journal of Pediatric Surgery. 2013 Jan; 48(1):158-63. ＃Corresponding author. PMID: 23331809. DOI: 10.1016/j.jpedsurg.2012.10.034 | Payam Saadai, Aijun Wang＃, Yvette Nout, Timothy Downing, Michael Beattie, Jacqueline Bresnahan, Song Li, Diana Farmer. |
2012 |
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| The effect of stromal cell-derived factor-1α/heparin coating of biodegradable vascular grafts on the recruitment of both endothelial and smooth muscle progenitor cells for accelerated regeneration. Biomaterials. 2012 Nov; 33(32):8062-74. PMID: 22884813. PMCID: PMC3488434. DOI: 10.1016/j.biomaterials.2012.07.042 | Jian Yu/Aijun Wang (Co-first author), Zhenyu Tang, Yiqian Zhu, Jeffrey Henry, Fengping Huang, Song Li. |
2012 |
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| Differentiation of Multipotent Vascular Stem Cells Contributes to Vascular Diseases. Nature Communications. 2012 Jun 6; 3:875. PMID: 22673902. PMCID: PMC3538044. DOI: 10.1038/ncomms1867. Reported by over 100 major news outlets worldwide: NPR’s Science Friday, SF Chronicle (FRONT page on 6/6/2012), Fox News, Medical News Today, US News & World Report, Daily Mail (UK), etc. The study was highlighted in Nature, 486, 9 (07 June 2012) DOI:10.1038/486009d. | Zhenyu Tang/Aijun Wang (Co-first author), Zhiqiang Yan, Bo Liu, Julia Chu, Jill Helms, Song Li. |
2012 |
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| Drug-eluting microfibrous patches for the local delivery of rolipram in spinal cord repair. Journal of Controlled Release. 2012 May 23; 161(3):910-917. PMCID: PMC3698241. DOI: 10.1016/j.jconrel.2012.05.034 | Timothy Downing/Aijun Wang (Co-first author), Zhiqiang Yan, Yvette Nout, Andy Lee, Michael S. Beattie, Jacqueline C. Bresnahan, Diana L. Farmer, Song Li. |
2012 |
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| Femtosecond Laser Ablation Enhances Cell Infiltration into Three-Dimensional Electrospun Scaffolds. Acta Biomaterialia. 2012 Jul;8(7):2648-58. PMID: 22522128. PMCID: PMC3425609. DOI: 10.1016/j.actbio.2012.04.023 | Benjamin Lee, Hojeong Jeon, Aijun Wang, Zhiqiang Yan, Jian Yu, Costas Grigoropoulos, Song Li. |
2012 |
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| Derivation of Smooth Muscle Cells with Neural Crest Origin from Human Induced Pluripotent Stem Cells. Cells Tissues Organs. 2012;195:5-14. PMID: 22005509. PMCID: PMC3257812. DOI: 10.1159/000331412 | Aijun Wang, Zhenyu Tang, Xian Li, Yisu Jiang, Danielle A. Tsou, Song Li. |
2012 |
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| Effects of Fluid Shear Stress on a Distinct Population of Vascular Smooth Muscle Cells. Cell and Molecular Bioengineering. 2011;4:627-36. PMID: 22924082. PMCID: PMC3425612. DOI: 10.1007/s12195-011-0205-8 | Steven Hsu, Julia Chu, Fanqing F. Chen, Aijun Wang, Song Li. |
2011 |
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| Prenatal Repair of Myelomeningocele with Aligned Nanofibrous Scaffolds – A Pilot Study in Sheep. The Journal of Pediatric Surgery. 2011,46:2279-83. PMID: 22152865. DOI: 10.1016/j.jpedsurg.2011.09.014 | Payam Saadai, Yvette Nout, Jose Encinas, Aijun Wang, Timothy Downing, Michael S. Beattie, Jacqueline C. Bresnahan, Song Li, Diana L. Farmer. |
2011 |
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| Uniaxial Mechanical Strain Modulates the Differentiation of Neural Crest Stem Cells into Smooth Muscle Lineage on Micropatterned Surfaces. PLoS ONE. 2011, 6(10): e26029. PMID: 22016804. PMCID: PMC3189240. DOI: 10.1371/journal.pone.0026029 | Xian Li, Julia S. Chu, Aijun Wang, Yiqian Zhu, Wai Keung Chu, Li Yang, Song Li. |
2011 |
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| Chitosan/silk Fibroin-based Tissue-engineered Graft Seeded with Adipose-derived Stem Cells Enhances Nerve Regeneration in a Rat Model. Journal of Materials Science: Materials in Medicine. 2011, 22(8):1947-64. PMID: 21656031. DOI: 10.1007/s10856-011-4370-z | Yujun Wei, Kai Gong, Zhenghuan Zheng, Aijun Wang, Qiang Ao, Yandao Gong, Xiufang Zhang. |
2011 |
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| Induced Pluripotent Stem Cells for Neural Tissue Engineering. Biomaterials. 2011, 32(22):5023-32. PMID: 21514663. PMCID: PMC3100451. DOI: 10.1016/j.biomaterials.2011.03.070 | Aijun Wang, Zhenyu Tang, In-Hyun Park, Yiqian Zhu, Shyam Patel, George Q. Daley, Song Li. |
2011 |
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| The Effect of Matrix Stiffness on the Differentiation of Mesenchymal Stem Cells in Response to TGF-β. Biomaterials. 2011, 32(16):3921-30. PMID: 21397942. PMCID: PMC3073995. DOI: 10.1016/j.biomaterials.2011.02.019 | Jennifer S. Park, Anchi D. Tsou, Rokhaya Diop, Zhenyu Tang, Aijun Wang, Song Li. |
2011 |
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| Engineering Bi-layer Nanofibrous Conduits for Peripheral Nerve Regeneration. Tissue Engineering. 2011, 17(7):705-15. PMID: 21501089. PMCID: PMC3124110. DOI: 10.1089/ten.tec.2010.0565 | Yiqian Zhu/Aijun Wang (Co-first author), Shyam Patel, Kyle Kurpinski, Edward Diao, Xuan Bao, George Kwong, William L. Young, Song Li. |
2011 |
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| Regulation of Neural Differentiation and Axon Growth by Growth Factors and Bioactive Nanofibers. Tissue Engineering. 2010, 16(8):2641-8. PMID: 20367289. PMCID: PMC2947452. DOI: 10.1089/ten.TEA.2009.0414 | Hayley Lam, Shyam Patel, Aijun Wang, Julia Chu, Song Li. |
2010 |
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| Schwann-like Cells Differentiation of Rat Adipose-derived Stem Cells by Indirect Co-culture with Schwann Cells in vitro. Cell Proliferation. 2010, 43(6):606-16. PMID: 21039999. DOI: 10.1111/j.1365-2184.2010.00710.x | Yujun Wei, Zhenghuan Zheng, Lingling Liu, Aijun Wang, Lihai Zhang, Qiang Ao, Yandao Gong, Xiufang Zhang. |
2010 |
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| The Effect of Topology of Chitosan Biomaterials on the Differentiation and Proliferation of Neural Stem Cells. Acta Biomaterialia. 2010, 6(9), 3630-9. PMID: 20371303. DOI: 10.1016/j.actbio.2010.03.039 | Gan Wang, Qiang Ao, Kai Gong, Aijun Wang, Yandao Gong, Xiufang Zhang. |
2010 |
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| Nanofibrous Patches for Spinal Cord Regeneration. Advanced Functional Materials. 2010, 20(9), 1433-40. PMID: 23378825. PMCID: PMC3558949. DOI: 10.1002/adfm.200901889 | Yiqian Zhu/Aijun Wang (Co-first author), Wenqian Shen, Shyam Patel, Rong Zhang, William Young, Song Li. |
2010 |
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| TGF-b and Notch Signaling Mediate Stem Cell Differentiation into Smooth Muscle Cells. Stem Cells. 2010, 28(4), 734-42. PMID: 20146266. DOI: 10.1002/stem.319 | Kyle Kurpinski, Hayley Lam, Julia Chu, Aijun Wang, Ahra Kim, Eric Tsay, Smita Agrawal, David Schaffer, Song Li. |
2010 |
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| The Behavior of MC3T3-E1 Cells on Chitosan/poly-L-lysine Composite Films: Effect of Nanotopography, Surface Chemistry, and Wettability. Journal of Biomedical Materials Research Part A. 2009, 89A(2):453-65. PMID: 18431777. DOI: 10.1002/jbm.a.31979 | Zhenhuan Zheng, Ling Zhang, Lijun Kong, Aijun Wang, Yandao Gong, Xiufang Zhang. |
2009 |
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| An Improved Method for Isolating Schwann Cells from Postnatal Rat Sciatic Nerves. Cell and Tissue Research. 2009, 337(3):361-9. PMID: 19639342. DOI: 10.1007/s00441-009-0836-4 | Yujun Wei, Jianli Zhou, Zhenghuan Zheng, Aijun Wang, Qiang Ao, Yandao Gong, Xiufang Zhang. |
2009 |
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| Surface Properties of Chitosan Films Modified with Polycations and Their Effects on the Behavior of PC12 Cells. Journal of Bioactive and Compatible Polymers. 2009, 24(1): 63-82. DOI: 10.1177/0883911508099653 | Zhenhuan Zheng, Yujun Wei, Gan Wang, Aijun Wang, Qiang Ao, Xiufang Zhang， |
2009 |
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| LEF-1 Activates the Transcription of E2F1. Biochemical and Biophysical Research Communications. 2008, 365(1):149-53. PMID:17980157. DOI: 10.1016/j.bbrc.2007.10.138 | Fangfang Zhou, Long Zhang, Kai Gong, Guangyuan Lu, Baiyang Sheng, Aijun Wang, Nanming Zhao, Xiufang Zhang, Yandao Gong. |
2008 |
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| The association of GSK3β with E2F1 Facilitates NGF-induced Neural Cell Differentiation. The Journal of Biological Chemistry 2008, 283(21):14506-15. PMID: 18367454. DOI: 10.1074/jbc.M706136200 | Fangfang Zhou, Long Zhang, Aijun Wang, Bo Song, Kai Gong, Lihai Zhang, Min Hu, Xiufang Zhang, Nanming Zhao, Yandao Gong. |
2008 |
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| Preparation and Characterization of a Multilayer Biomimetic Scaffold for Bone Tissue Engineering. Journal of Biomaterials Applications. 2007, 22(3):223-39. PMID: 17255157. DOI: 10.1177/0885328206073706 | Lijun Kong, Qiang Ao, Aijun Wang, Kai Gong, Xi Wang, Guangyuan Lu, Yandao Gong, Nanming Zhao, Xiufang Zhang. |
2007 |
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| Combined Transplantation of Neural Stem Cells and Olfactory Ensheathing Cells for the Repair of Spinal Cord Injuries. Medical Hypotheses. 2007, 69(6):1234-7. PMID: 17548168. DOI: 10.1016/j.mehy.2007.04.011 | Qiang Ao/Aijun Wang (Co-first author), Guoqiang Chen, Shijie Wang, Huancong Zuo, Xiufang Zhang. |
2007 |
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| Physical Properties and Biocompatibility of a Porous Chitosan-based Fibre-reinforced Conduit for Nerve Regeneration. Biotechnology Letters. 2007, 29(11):1697-702. PMID: 17628751. DOI: 10.1007/s10529-007-9460-0 | Aijun Wang, Qiang Ao, Yujun Wei, Kai Gong, Nanming Zhao, Yandao Gong, Xiufang Zhang. |
2007 |
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| In Vitro Cytotoxicity and Protein Drug Release Properties of Chitosan/Heparin Microspheres. Tsinghua Science and Technology. 2007, 12(4): 361-5. DOI: 10.1016/S1007-0214(07)70054-8 http://dx.doi.org/10.1016/S1007-0214(07)70054-8 | Qing He, Qiang Ao, Aijun Wang, Yandao Gong, Nanming Zhao, Xiufang Zhang. |
2007 |
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| Effect of Multilayer Biomimetic Nano-hydroxyapatite/chitosan Composite Scaffolds on Repairing Rabbit Fibula Defect. Journal of Clinical Rehabilitative Tissue Engineering Research. 2007,11(5):815-8. (in Chinese) | Lijun Kong, Qiang Ao, Aijun Wang, Kai Gong, Xi Wang, Yandao Gong, Nanming Zhao, Xiufang Zhang. |
2007 |
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| Protective Effects of Extract of Ginkgo Biloba (EGb 761) on Nerve Cells after Spinal Cord Injury in Rats. Spinal Cord. 2006, 44(11): 662-7. PMID: 16415923. DOI: 10.1038/sj.sc.3101900 | Qiang Ao, Xiuhua Sun, Aijun Wang, Panfeng Fu, Kai Gong, Yandao Gong, Xiufang Zhang. |
2006 |
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| Encapsulation of Drug Reservoirs in Fibers by Emulsion Electrospinning: Morphology Characterization and Preliminary Release Assessment. Biomacromolecules. 2006, 7(8): 2327-30. PMID: 16903678. DOI: 10.1021/bm060264z | Hongxu Qi, Ping Hu, Jun Xu, Aijun Wang. |
2006 |
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| A Sandwich Tubular Scaffold Derived from Chitosan for Blood Vessel Tissue Engineering. Journal of Biomedical Materials Research Part A. 2006, 77A(2):277-84. PMID: 16400655. DOI: 10.1002/jbm.a.30614 | Ling Zhang, Qiang Ao, Aijun Wang, Guangyuan Lu, Lijun Kong, Yandao Gong, Nanming Zhao, Xiufang Zhang. |
2006 |
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| Manufacture of Multi-microtubule Chitosan Nerve Conduits with Novel Molds and Characterization in vitro. Journal of Biomedical Materials Research Part A. 2006, 77A(1):11-8. PMID: 16345091. DOI: 10.1002/jbm.a.30593 | Qiang Ao, Aijun Wang, Wenling Cao, Ling Zhang, Lijun Kong, Qing He, Yandao Gong, Xiufang Zhang. |
2006 |
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| Porous Chitosan Tubular Scaffolds with Knitted Outer Wall and Controllable Inner Structure for Nerve Tissue Engineering. Journal of Biomedical Materials Research Part A. 2006, 79A(1): 36-46. PMID: 16758450. DOI: 10.1002/jbm.a.30683 | Aijun Wang, Qiang Ao, Wenling Cao, Mingzhi Yu, Qing He, Lijun Kong, Ling Zhang, Yandao Gong, Xiufang Zhang. |
2006 |
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| Neural Stem Cell Affinity of Chitosan and Feasibility of Chitosan-based Porous Conduits as Scaffolds for Nerve Tissue Engineering. Tsinghua Science and Technology. 2006, 11(4):415-20. http://dx.doi.org/10.1016/S1007-0214(06)70210-3 | Aijun Wang, Qiang Ao, Qing He, Xiaoming Gong, Kai Gong, Yandao Gong, Nanming Zhao, Xiufang Zhang. |
2006 |
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| Fiber-based Chitosan Tubular Scaffolds for Soft Tissue Engineering: Fabrication and in vitro Evaluation. Tsinghua Science and Technology. 2005, 10(4):449-53. DOI: 10.1016/S1007-0214(05)70099-7 http://dx.doi.org/10.1016/S1007-0214(05)70099-7 | Aijun Wang, Qiang Ao, Wenling Cao, Chang Zhao, Yandao Gong, Nanming Zhao, Xiufang Zhang. |
2005 |
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| Novel Biodegradable Films and Scaffolds of Chitosan Blended with Poly(3-hydroxybutyrate). Journal of Biomaterials Science, Polymer Edition. 2005, 16(11):1379-94. PMID: 16370239. DOI: 10.1163/156856205774472308 | Wenling Cao, Aijun Wang, Duohui Jing, Yandao Gong, Nanming Zhao, and Xiufang Zhang. |
2005 |
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| Fabrication and Characterization of Chitosan Nerve Conduits with Microtubular Architecture. Tsinghua Science and Technology. 2005, 10(4):435-8. DOI: 10.1016/S1007-0214(05)70096-1 | Qiang Ao, Aijun Wang, Wenling Cao, Chang Zhao, Yandao Gong, Nanming Zhao, Xiufang Zhang. |
2005 |
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| Preparation of Porous Multi-channeled Chitosan Conduits for Nerve Tissue Engineering. Key Engineering Materials. 2005, (288-289): 27-30. DOI: 10.4028/www.scientific.net/KEM.288-289.27 | Qiang. Ao, Aijun Wang, Wengling Cao, Chang Zhao, Yandao Gong, Nanming Zhao, Xiufang Zhang. |
2005 |
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