Members
Aijun Wang
Chancellor’s Fellow, Professor of Surgery and Biomedical Engineering
Co-Director, Center for Surgical Bioengineering & Vice Chair for Translational Research, Innovation and Entrepreneurship
Department of Surgery, University of California, Davis
4625 2nd Ave., Research II, Room 3005, Sacramento, CA 95817
(916) 703-0422
aawang (at) ucdavis.edu
Education
- B.S., Pharmaceutical Chemistry, Shandong Medical University, Jinan, China
- M.S., Biochemical Drugs, Shandong University, Jinan, China
- Ph.D., Biology, Tsinghua University, Beijing, China
- Postdoc, Berkeley Stem Cell Center
- Postdoc, University of California Berkeley
Research Interests
Stem cell biology, nanomedicine, biomaterial scaffold, tissue engineering, fetal treatment of birth defects, vascular and neural tissue regeneration, wound healing
Dr. Wang’s research focuses on developing tools, technologies and products that combine molecular, cellular, tissue and biomaterial engineering to promote regeneration and restore function. Specifically, the focus of the Wang Group is on engineering and developing stem cell/gene therapy, extracellular vesicles/nanomedicine, and extracellular matrix/biomaterial scaffolds for the treatment of surgical conditions and diseases. Dr. Wang and his team specialize in bringing therapeutics from bench to bedside, through translational and IND-enabling studies, GMP manufacturing, and conducting clinical trials in both human and companion animal patients.
Please see: Dr. Wang’s laboratory website for more information.
2022
Kaitlin Clark, Ashley Amador, Aijun Wang. Convergence of human and veterinary medicine: Leveraging canine naturally occurring neurological disorders to develop regenerative treatments.
Neural Regeneration Research. 2023, Mar;18(3):541-542. PMID: 36018168. DOI: 10.4103/1673-5374.350195 Download PDF
Dake Hao, Lu Lu, Hengyue Song, Yixin Duan, Jianing Chen, Randy Carney, Jian Jian Li, Ping Zhou, Jan Nolta, Kit S. Lam, J. Kent Leach, Diana L Farmer, Alyssa Panitch, Aijun Wang. Engineered extracellular vesicles with high collagen-binding affinity present superior in situ retention and therapeutic efficacy in tissue repair.
Theranostics. 2022 Aug 8; 12(13):6021-6037. PMID: 35966577. PMCID: PMC9373818. DOI: 10.7150/thno.70448 Download PDF
Lalithasri Ramasubramanian, Shixian Du, Siraj Gidda, Nataliya Bahatyrevich, Dake Hao, Priyadarsini Kumar, Aijun Wang. Bioengineering Extracellular Vesicles for the Treatment of Cardiovascular Diseases. Advanced Biology, 2022, Jul 1; e2200087. PMID: 35778828. DOI: 10.1002/adbi.202200087 Download PDF
Abd-Elrahman Said Hassan, Yimeng Lina Du, Su Yeon Lee, Aijun Wang, Diana Lee Farmer. Spina Bifida: A Review of the Genetics, Pathophysiology and Emerging Cellular Therapies. J Dev Biol. 2022, Jun 6;10(2):22. PMID: 35735913. DOI: 10.3390/jdb10020022 Download PDF
Dake Hao, Ruiwu Liu, Tomas Gonzalez Fernandez, Christopher Pivetti, Jordan Elizabeth Jackson, Edwin Samuel Kulubya, Hong-Jiang Jiang, Hai-Yang Ju, Wen-Liang Liu, Alyssa Panitch, Kit S. Lam, J. Kent Leach, Diana L. Farmer, Aijun Wang. A bioactive material with dual integrin-targeting ligands regulates specific endogenous cell adhesion and promotes vascularized bone regeneration in adult and fetal bone defects. Bioactive Materials. 2022, May 29;20:179-193. PMID: 35663336. PMCID: PMC9160290. DOI: 10.1016/j.bioactmat.2022.05.027 Download PDF
Dake Hao, Juan-Maria Lopez, Jianing Chen, Alexandra Maria Iavorovschi, Nora Marlene Lelivelt, Aijun Wang. Engineering Extracellular Microenvironment for Tissue Regeneration. Bioengineering. 2022 May 8;9(5):202. PMID: 35621480. PMCID: PMC9137730. DOI: 10.3390/bioengineering9050202 Download PDF
Alexander Stahl+, Dake Hao+, Janos Barrera, Dominic Henn, Sien Lin, Seyedsina Moeinzadeh, Sungwoo Kim, William Maloney, Geoffrey Gurtner, Aijun Wang#, Yunzhi Peter Yang#. A Bioactive Compliant Vascular Graft Modulates Macrophage Polarization and Maintains Patency with Robust Vascular Remodeling. Bioactive Materials. 2022, Apr 13;19:167-178. +Co-first author; #Co-corresponding author. PMID: 35510174. PMCID: PMC9034314. DOI: 10.1016/j.bioactmat.2022.04.004 Download PDF
Nian Jiang, Bowen Xie, Wenwu Xiao, Ming Fan, Shanxiu Xu, Yixin Duan, Yamah Hamsafar, Angela C Evans, Jie Huang, Weibing Zhou, Xuelei Lin, Ningrong Ye, Siyi Wanggou, Wen Chen, Di Jing, Ruben C Fragoso, Brittany N Dugger, Paul F Wilson, Matthew A Coleman, Shuli Xia, Xuejun Li, Lun-Quan Sun, Arta M Monjazeb, Aijun Wang, William J Murphy, Hsing-Jien Kung, Kit S Lam, Hong-Wu Chen, Jian Jian Li. Fatty acid oxidation fuels glioblastoma radioresistance with CD47-mediated immune evasion. Nature Communications. 2022, Mar 21;13(1):1511. PMID: 35314680. PMCID: PMC8938495. DOI: 10.1038/s41467-022-29137-3 Download PDF
Su Yeon Lee, Emma Grace Loll, Abd-Elrahman Said Hassan, Mingyu Cheng, Aijun Wang, Diana Lee Farmer. Genetic and Molecular Determinants of Lymphatic Malformations: Potential Targets for Therapy. J Dev Biol. 2022 Feb 8;10(1):11. PMID: 35225964. PMCID: PMC8883961. DOI: 10.3390/jdb10010011 Download PDF
Sarah Stokes, Sandra K Kabagambe, Chelsey J Lee, Aijun Wang, Diana Lee Farmer, Priyadarsini Kumar. Impact of Gestational Age on Neuroprotective Function of Placenta-Derived Mesenchymal Stromal Cells. J Surg Res. 2022 Jan 27; 273:201-210. PMID: 35093836. DOI: 10.1016/j.jss.2021.12.039 Download PDF
Christina M Theodorou, Jordan E Jackson, Sarah C Stokes, Christopher D Pivetti, Priyadarsini Kumar, Zachary J Paxton, Karen E Matsukuma, Kaeli J Yamashiro, Lizette Reynaga, Alicia A Hyllen, Arthur J de Lorimier, Maheen Hassan, Aijun Wang, Diana L Farmer, Payam Saadai. Early investigations into improving bowel and bladder function in fetal ovine myelomeningocele repair. Journal of Pediatric Surgery. 2022 May; 57(5): 941-948. PMID: 35093254. DOI: 10.1016/j.jpedsurg.2021.12.046 Download PDF
Kaitlin Clark, David Wang, Priyadarsini Kumar, Sirjan Mor, Edwin S Kulubya, Sabrina Lazar, Aijun Wang. The Molecular Mechanisms Through Which Placental Mesenchymal Stem Cell-Derived Extracellular Vesicles Promote Myelin Regeneration. Advanced Biology, 2022 Jan 13; e2101099. PMID: 35023637. DOI: 10.1002/adbi.202101099
Sabrina Valentina Lazar, Sirjan Mor, David Wang, Leora Goldbloom-Helzner, Kaitlin Clark, Dake Hao, Diana Lee Farmer, Aijun Wang. Engineering extracellular vesicles for Alzheimer’s disease: an emerging cell-free approach for earlier diagnosis and treatment. WIREs Mechanisms of Disease 2022, Mar;14(2): e1541. PMID: 35266650. DOI: https://doi.org/10.1002/wsbm.1541 Download PDF
2021
Siqi He, Tanaya Walimbe, Hongyuan Chen, Kewa Gao, Priyadarsini Kumar, Yifan Wei, Dake Hao, Ruiwu Liu, Diana L. Farmer, Kit S. Lam, Jianda Zhou, Alyssa Panitch, Aijun Wang. Bioactive extracellular matrix scaffolds engineered with proangiogenic proteoglycan mimetics and loaded with endothelial progenitor cells promote neovascularization and diabetic wound healing. Bioactive Materials. 2021, Sep 11;10:460-473. PMID: 34901560. PMCID: PMC8636679. DOI: 10.1016/j.bioactmat.2021.08.017 Download PDF
Edwin S Kulubya, Kaitlin Clark, Dake Hao, Sabrina Lazar, Arash Ghaffari-Rafi, Tejas Karnati, Julius Okudu Ebinu, Marike Zwienenberg, Diana L Farmer, Aijun Wang. The Unique Properties of Placental Mesenchymal Stromal Cells: A Novel Source of Therapy for Congenital and Acquired Spinal Cord Injury. Cells. 2021, 10(11), 2837. PMID: 34831060. PMCID: PMC8616037. DOI: 10.3390/cells10112837 Download PDF
Feng Xie, Peng Su, Ting Pan, Xiaoxue Zhou, Heyu Li, Huizhe Huang, Aijun Wang, Fangwei Wang, Jun Huang, Haiyan Yan, Linghui Zeng, Long Zhang, Fangfang Zhou. Engineering Extracellular Vesicles Enriched with Palmitoylated ACE2 as COVID-19 Therapy. Adv Mater. 2021 Oct 19; e2103471. PMID: 34665481. DOI: 10.1002/adma.202103471 Download PDF
Sarah Stokes, Christina M. Theodorou, Jordan E. Jackson, Christopher D. Pivetti, Priyadarsini Kumar, Kaeli Yamashiro, Zachary J Paxton, Lizette Reynaga, Alicia A Hyllen, Aijun Wang, Diana Lee Farmer. Long-term safety evaluation of placental mesenchymal stromal cells for in utero repair of myelomeningocele in a novel ovine model. J Surg Res. 2021 Sep 20; S0022-3468(21)00640-0. Online ahead of print. PMID: 34657738. DOI: 10.1016/j.jpedsurg.2021.09.021 Download PDF
Shuang Lin, Yuanjia He, Meihan Tao, Aijun Wang, Qiang Ao. Fabrication and evaluation of an optimized xenogenic decellularized costal cartilage graft: preclinical studies of a novel biocompatible prosthesis for rhinoplasty. Regen Biomater. 2021 Sep 16;8(6): rbab052. PMID: 34584748. PMCID: PMC8473975. DOI: 10.1093/rb/rbab052 Download PDF
Rachel R. Mizenko1, Terza Brostof, Tatu Rojalin, Hanna J. Koster, Hila S. Swindell, Gary S. Leiserowitz, Aijun Wang, Randy P. Carney. Tetraspanins are unevenly distributed across single extracellular vesicles and bias sensitivity to multiplexed cancer biomarkers. Journal of Nanobiotechnology. 2021 Aug 21;19(1):250. PMID: 34419056. PMCID: PMC8379740. DOI: 10.1186/s12951-021-00987-1 Download PDF
Sarah Stokes, Kaeli Yamashiro, Melissa A. Vanover, Laura A. Galganski, Jordan E. Jackson, Christina M. Theodorou, Christopher D. Pivetti, Diana Lee Farmer, Aijun Wang. Preliminary Evaluation of a Novel Fetal Guinea Pig Myelomeningocele Model. BioMed Research International. 2021 Aug 13; 2021:2180883. PMID: 34423032. PMCID: PMC8378975. DOI: 10.1155/2021/2180883 Download PDF
Aida Nasirishargh, Priyadarsini Kumar, Lalithasri Ramasubramanian, Kaitlin Clark, Dake Hao, Sabrina V Lazar, Aijun Wang. Exosomal microRNAs from mesenchymal stem/stromal cells: Biology and applications in neuroprotection. World J Stem Cells. 2021 Jul 26;13(7):776-794. PMID: 34367477. PMCID: PMC8316862. DOI: 10.4252/wjsc.v13.i7.776 Download PDF
Jordan Jackson, Christopher Pivetti, Sarah Stokes, Christina Theodorou, Priyadarsini Kumar, Zachary J Paxton, Alicia A Hyllen, Lizette Reynaga, Aijun Wang, Diana Farmer. Placental mesenchymal stromal cells: Preclinical Safety Evaluation for Fetal Myelomeningocele Repair. J Surg Res. 2021 Jul 14; 267:660-668. PMID: 34273796. PMID: 34273796. DOI: 10.1016/j.jss.2021.06.011 Download PDF
Christina Theodorou, Sarah Stokes, Jordan Jackson, Christopher Pivetti, Priyadarsini Kumar, Kaeli Yamashiro, Zachary J Paxton, Lizette Reynaga, Alicia A Hyllen, Aijun Wang, Diana Farmer. Efficacy of clinical-grade human placental mesenchymal stromal cells in fetal ovine myelomeningocele repair. J Pediatr Surg. 2021 Jun 5; S0022-3468(21)00435-8. PMID: 34217509. DOI: 10.1016/j.jpedsurg.2021.05.025 Download PDF
Sabrina Lazar, Sirjan Mor, Jianing Chen, Dake Hao, Aijun Wang. Bioengineered extracellular vesicle-loaded bioscaffolds for therapeutic applications in regenerative medicine. Extracell Vesicles Circ Nucleic Acids 2021; 2:175-178. PMID: 34622248. PMCID: PMC8494210. DOI: 10.20517/evcna.2021.10 Download PDF
Tanaya Walimbe, Tima Dehghani, Alena Casella, Jenny Lin, Aijun Wang, Alyssa Panitch. Proangiogenic Collagen-Binding Glycan Therapeutic Promotes Endothelial Cell Angiogenesis. ACS Biomater Sci Eng. 2021, Jul 12;7(7):3281-3292. PMID: 34192455. DOI: 10.1021/acsbiomaterials.1c00336 Download PDF
Sarah Stokes, Jordan Jackson, Christina Theodorou, Christopher Pivetti, Priyadarsini Kumar, Kaeli Yamashiro, Aijun Wang, Diana Farmer. A Novel Model of Fetal Spinal Cord Exposure Allowing for Long-Term Postnatal Survival. Fetal Diagn Ther. 2021 Jun 10; Jun 10; 48(6):472-478. PMID: 34111873. DOI: 10.1159/000516542 Download PDF
Yu Yan, Hong Liu, Jiarong Yi, Zizi Chen, Jia Chen, Jianfei Zhang, Kewa Gao, Siqi He, Aijun Wang, Ping Jin, Feng Hu, Jianda Zhou. Identification of differentially expressed proteins involved in fetal scarless wound healing using a rat model of cleft lip. Mol Med Rep. 2021 Aug; 24(2):596. PMID: 34165164. DOI: 10.3892/mmr.2021.12235 Download PDF
Andrew Li, Clifford Pereira, Elise Eleanor Hill, Olivia Vukcevich, Aijun Wang. In vitro, In vivo and Ex vivo Models for Peripheral Nerve Injury and Regeneration. Curr Neuropharmacol. 2021, Apr 7. Online ahead of print. PMID: 33827409. DOI: 10.2174/1570159X19666210407155543
Jennifer Soto, Xili Ding, Aijun Wang, Song Li. Neural crest-like stem cells for tissue regeneration. STEM CELLS Transl Med. 2021, May;10(5):681-693. PMID: 33533168. DOI: 10.1002/sctm.20-0361. Download PDF
2020
Wenguo Cui, Aijun Wang, Chao Zhao, Wuqiang Zhu. Editorial: Nanotechnology in Cardiovascular Regenerative Medicine. Frontiers in Bioengineering and Biotechnology. 2020 Oct 23; 8:608844. PMID: 33195180. PMCID: PMC7644819. DOI: 10.3389/fbioe.2020.608844 Download PDF
Lu Lu, Hongyuan Chen, Longkun Wang, Lin Zhao, Yanna Cheng, Aijun Wang, Fengshan Wang, Xinke Zhang. A Dual Receptor Targeting- and BBB Penetrating- Peptide Functionalized Polyethyleneimine Nanocomplex for Secretory Endostatin Gene Delivery to Malignant Glioma. International Journal of Nanomedicine. 2020, Nov 12; 8875-8892. PMID: 33209022. PMCID: PMC7669533. DOI: 10.2147/IJN.S270208. Download PDF
Kaeli Yamashiro, Laura Galganski, Jamie Peyton, Kalie Haynes, Victoria Vicuna, Priyadarsini Kumar, Benjamin Keller, James Becker, Christopher Pivetti, Sarah Stokes, Christina Theodorou, Jordan Jackson, Aijun Wang, Diana Farmer. Surviving Lambs with Myelomeningocele Repaired in utero with Placental Mesenchymal Stromal Cells for 6 Months: A Pilot Study. Fetal Diagn Ther. 2020;47(12):912-917. PMID: 33166951. PMCID: PMC7746588. DOI: 10.1159/000510813 Download PDF
Demet Candas-Green, Bowen Xie, Jie Huang, Ming Fan, Aijun Wang, Cheikh Menaa, Yanhong Zhang, Lu Zhang, Di Jing, Soheila Azghadi, Weibing Zhou, Lin Liu, Nian Jiang, Tao Li, Tianyi Gao, Colleen Sweeney, Rulong Shen, Tzu-yin Lin, Chong-xian Pan, Omer M. Ozpiskin, Gayle Woloschak, David J. Grdina, Andrew T. Vaughan, Ji Ming Wang, Shuli Xia, Arta M. Monjazeb, William J. Murphy, Lun-Quan Sun, Hong-Wu Chen, Kit S. Lam, Ralph R. Weichselbaum, Jian Jian Li. Dual blockade of CD47 and HER2 eliminates radioresistant breast cancer cells. Nature Communications.2020, Sept 14;11(1): 4591. PMID: 32929084. DOI: 10.1038/s41467-020-18245-7 Download PDF
Dake Hao, Ruiwu Liu, Kewa Gao, Chuanchao He, Siqi He, Cunyi Zhao, Gang Sun, Diana L Farmer, Alyssa Panitch, Kit S Lam, Aijun Wang. Developing an injectable nanofibrous extracellular matrix hydrogel with an integrin αvβ3 ligand to improve endothelial cell survival, engraftment and vascularization. Frontiers in Bioengineering and Biotechnology. 2020, Jul 29;8:890. July 29. PMID: 32850742. PMCID: PMC7403189. DOI: 10.3389/fbioe.2020.00890 Download PDF
Rogério Martins Amorim, Kaitlin C. Clark, Naomi J. Walker, Priyadarsini Kumar, Kyle Herout, Dori L. Borjesson, Aijun Wang. Placenta-Derived Multipotent Mesenchymal Stromal/Stem Cells: A Promising Potential Cell-Based Therapy for Canine Inflammatory Brain Disease. Stem Cell Research & Therapy. 2020, Jul 22;11(1):304. PMID: 32698861. DOI: 10.1186/s13287-020-01799-0 Download PDF
Zhengkui Zhang, Xiuwu Fang, Xiaojin Wu, Li Ling, Feng Chu, Jingxian Li, Shuai Wang, Jia Zang, Bo Zhang, Sheng Ye, Long Zhang, Bing Yang, Shixian Lin, Huizhe Huang, Aijun Wang, Fangfang Zhou. Acetylation-Dependent Deubiquitinase OTUD3 Controls MAVS Activation in Innate Antiviral Immunity. Molecular Cell. 2020 Jul 16;79(2):304-319.e7. PMID: 32679077. DOI: 10.1016/j.molcel.2020.06.020 Download PDF
Dake Hao, Hila Shimshi Swindell, Lalithasri Ramasubramanian, Ruiwu Liu, Kit S Lam, Diana L Farmer, Aijun Wang. Extracellular matrix mimicking nanofibrous scaffolds modified with mesenchymal stem cell-derived extracellular vesicles for improved vascularization. Frontiers in Bioengineering and Biotechnology. 2020, June 25;8:633. PMID: 32671037. PMCID: PMC7329993. DOI: 10.3389/fbioe.2020.00633 Download PDF
Alexandra M. Iavorovschi, Aijun Wang. Engineering Mesenchymal Stromal/Stem Cell-Derived Extracellular Vesicles with Improved Targeting and Therapeutic Efficiency for the Treatment of Central Nervous System Disorders. Neural Regeneration Research. 2020 Dec; 15(12):2235-2236. PMID: 32594034. DOI: 10.4103/1673-5374.284982 Download PDF
Lili Zhou, Yuqi Zhang, Yongqiang Wang, Meirong Zhang, Wenhuan Sun, Tong Dai, Aijun Wang, Xiaojin Wu, Suping Zhang, Shuai Wang, Fangfang Zhou. A Dual Role of Type I Interferons in Antitumor Immunity. Advanced Biosystems. 2020, March 13. Online ahead of print. https://doi.org/10.1002/adbi.201900237 Download PDF
Shujing Guo, Yan Wang, Aijun Wang. Identity and lineage fate of proteolipid protein 1 gene (Plp1)-expressing cells in the embryonic murine spinal cord. Developmental Dynamics. 2020 Apr 30. Online ahead of print. PMID: 32353175. DOI: 10.1002/dvdy.184 Download PDF
Sheng Zhang, Bokyung Kim, Xiaoqing Zhu, Xuehong Gui, Yan Wang, Zhaohui Lan, Preeti Prabhu, Kenneth Fond, Aijun Wang, Fuzheng Guo. Glial type specific regulation of CNS angiogenesis by HIFα-activated different signaling pathways. Nature Communications. 2020. Apr 24;11(1):2027. PMID: 32332719. DOI: 10.1038/s41467-020-15656-4. Download PDF
Melanie Rose*, Kewa Gao*, Elizabeth Cortez-Toledo, Emmanuel Agu, Alicia A. Hyllen, Kelsey Conroy, Guangjin Pan, Jan A. Nolta, Aijun Wang#, Ping Zhou#. Endothelial cells derived from patients’ induced pluripotent stem cells for sustained factor VIII delivery and the treatment of hemophilia A. STEM CELLS Transl Med. 2020, Mar 12. *Co-first author; #Co-corresponding author. PMID: 32162786. DOI: https://doi.org/10.1002/sctm.19-0261 Download PDF
Dake Hao, Yahan Fan, Wenwu Xiao, Ruiwu Liu, Christopher Pivetti, Tanaya Walimbe, Fuzheng Guo, Xinke Zhang, Diana L Farmer, Fengshan Wang, Alyssa Panitch, Kit S Lam, Aijun Wang. Rapid endothelialization of small diameter vascular grafts by a bioactive integrin-binding ligand specifically targeting endothelial progenitor cells and endothelial cells. Acta Biomaterialia. 2020, May;108:178-193. PMID: 32151698. DOI: 10.1016/j.actbio.2020.03.005 Download PDF
Ngan F. Huang, Ovijit Chaudhuri, Patrick Cahan, Aijun Wang, Adam J. Engler, Yingxiao Wang, Sanjay Kumar, Ali Khademhosseini, Song Li. Multi-scale cellular engineering: From molecules to organ-on-a-chip. APL Bioengineering. 2020, 4, 010906. DOI: 10.1063/1.5129788 Download PDF
Jin-Ho Kang, Janelle Kaneda, Jae-Gon Jang, Kumaresan Sakthiabirami, Elaine Lui, Carolyn Kim, Aijun Wang, Sang-Won Park, Yunzhi Peter Yang. The Influence of Electron Beam Sterilization on In Vivo Degradation of β-TCP/PCL of Different Composite Ratios for Bone Tissue Engineering. Micromachines 2020, 11(3), 273. DOI: https://doi.org/10.3390/mi11030273 Download PDF
Galganski L.A, Yamashiro K.J, Pivetti C.D, Keller B.A, Becker J.C, Brown E.G, Saadai P, Hirose S, Wang A, Farmer D.L. A Decade of Experience with the Ovine Model of Myelomeningocele: Risk Factors for Fetal Loss. Fetal Diagn Ther. 2020 Feb 25:1-7. PMID: 32097922. DOI: 10.1159/000505400 Download PDF
Qiang Ao, Shilin Wang, Qing He, Hirotomo Ten, Kenichi Oyama, Akihiro Ito, Jing He, Rabia Javed, Aijun Wang, Akira Matsuno. Fibrin Glue/Fibronectin/Heparin-Based Delivery System of BMP2 Induces Osteogenesis in MC3T3-E1 Cells and Bone Formation in Rat Calvarial Critical-Sized Defects. ACS Appl. Mater. Interfaces, 2020, Mar 18;12(11):13400-13410. PMID: 32091872. DOI: 10.1021/acsami.0c01371 Download PDF
Kewa Gao, Siqi He, Priyadarsini Kumar, Diana Farmer, Jianda Zhou, Aijun Wang. Clonal isolation of endothelial colony-forming cells from early gestation chorionic villi of human placenta for fetal tissue regeneration. World J Stem Cells. Feb 26, 2020; 12(2): 123-138. DOI: 10.4252/wjsc.v12.i2.123 Download PDF
Dake Hao, Bowen Ma, Chuanchao He, Ruiwu Liu, Diana L. Farmer, Kit Lam, Aijun Wang. Surface Modification of Polymeric Electrospun Scaffolds via a Potent and High-Affinity Integrin α4β1 Ligand Improved the Adhesion, Spreading and Survival of Human Chorionic Villus-Derived Mesenchymal Stem Cells: A New Insight for Fetal Tissue Engineering. Journal of Materials Chemistry B, 2020 Feb 26;8(8):1649-1659. PMID: 32011618. DOI: 10.1039/c9tb02309g Download PDF
2019
Tan J, Xie Y, Yao A, Qin Y, Li L, Shen L, Zhang X, Xu C, Jiang X, Wang A, Yan Z. Long noncoding RNA-dependent regulation of vascular smooth muscle cell proliferation and migration in hypertension. Int J Biochem Cell Biol. 2020 Jan;118:105653. doi: 10.1016/j.biocel.2019.105653. Epub 2019 Nov 16. PubMed PMID: 31743794. Download PDF
Henry JJD, Delrosario L, Fang J, Wong SY, Fang Q, Sievers R, Kotha S, Wang A, Farmer D, Janaswamy P, Lee RJ, Li S. Development of Injectable Amniotic Membrane Matrix for Postmyocardial Infarction Tissue Repair. Adv Healthc Mater. 2020 Jan;9(2):e1900544. doi: 10.1002/adhm.201900544. Epub 2019 Nov 28. PubMed PMID: 31778043; PubMed Central PMCID: PMC6986802. Download PDF
Ramasubramanian L, Kumar P, Wang A. Engineering Extracellular Vesicles as Nanotherapeutics for Regenerative Medicine. Biomolecules. 2019 Dec 28;10(1). doi: 10.3390/biom10010048. Review. PubMed PMID: 31905611; PubMed Central PMCID: PMC7023093. Download PDF
Clark K, Zhang S, Barthe S, Kumar P, Pivetti C, Kreutzberg N, Reed C, Wang Y, Paxton Z, Farmer D, Guo F, Wang A. Placental Mesenchymal Stem Cell-Derived Extracellular Vesicles Promote Myelin Regeneration in an Animal Model of Multiple Sclerosis. Cells. 2019 Nov 23;8(12). doi: 10.3390/cells8121497. PubMed PMID: 31771176; PubMed Central PMCID: PMC6952942. Download PDF
Hao D, He C, Ma B, Lankford L, Reynaga L, Farmer DL, Guo F, Wang A. Hypoxic Preconditioning Enhances Survival and Proangiogenic Capacity of Human First Trimester Chorionic Villus-Derived Mesenchymal Stem Cells for Fetal Tissue Engineering. Stem Cells Int. 2019;2019:9695239. doi: 10.1155/2019/9695239. eCollection 2019. PubMed PMID: 31781252; PubMed Central PMCID: PMC6874947. Download PDF
Liao J, Chen Y, Chen J, He B, Qian L, Xu J, Wang A, Li Q, Xie H, Zhou J. Auricle shaping using 3D printing and autologous diced cartilage. Laryngoscope. 2019 Nov;129(11):2467-2474. doi: 10.1002/lary.27752. Epub 2019 Mar 7. PubMed PMID: 30843613; PubMed Central PMCID: PMC6850318. Download PDF
Xue YN, Yan Y, Chen ZZ, Chen J, Tang FJ, Xie HQ, Tang SJ, Cao K, Zhou X, Wang AJ, Zhou JD. LncRNA TUG1 regulates FGF1 to enhance endothelial differentiation of adipose-derived stem cells by sponging miR-143. J Cell Biochem. 2019 Nov;120(11):19087-19097. doi: 10.1002/jcb.29232. Epub 2019 Jul 1. PubMed PMID: 31264280. Download PDF
Goldbloom-Helzner L, Hao D, Wang A. Developing Regenerative Treatments for Developmental Defects, Injuries, and Diseases Using Extracellular Matrix Collagen-Targeting Peptides. Int J Mol Sci. 2019 Aug 21;20(17). doi: 10.3390/ijms20174072. Review. PubMed PMID: 31438477; PubMed Central PMCID: PMC6747276. Download PDF
Liu C, Chen W, Chen Z, Yan Y, Wang Q, Xie H, Chen X, Wang A, Tang S, Zhou J. Studies on the treatment of melanoma with folate acid conjugated dextran and lauryl alcohol loaded with IMD0354. Onco Targets Ther. 2019;12:4655-4663. doi: 10.2147/OTT.S207685. eCollection 2019. PubMed PMID: 31354298; PubMed Central PMCID: PMC6585409. Download PDF
Kumar P, Becker JC, Gao K, Carney RP, Lankford L, Keller BA, Herout K, Lam KS, Farmer DL, Wang A. Neuroprotective effect of placenta-derived mesenchymal stromal cells: role of exosomes. FASEB J. 2019 May;33(5):5836-5849. doi: 10.1096/fj.201800972R. Epub 2019 Feb 12. PubMed PMID: 30753093; PubMed Central PMCID: PMC6463921. Download PDF
Zhu Y, Li X, Janairo RRR, Kwong G, Tsou AD, Chu JS, Wang A, Yu J, Wang D, Li S. Matrix stiffness modulates the differentiation of neural crest stem cells in vivo. J Cell Physiol. 2019 May;234(5):7569-7578. doi: 10.1002/jcp.27518. Epub 2018 Oct 26. PubMed PMID: 30368818; PubMed Central PMCID: PMC6995283. Download PDF
Vanover M, Pivetti C, Galganski L, Kumar P, Lankford L, Rowland D, Paxton Z, Deal B, Wang A, Farmer D. Spinal Angulation: A Limitation of the Fetal Lamb Model of Myelomeningocele. Fetal Diagn Ther. 2019;46(6):376-384. doi: 10.1159/000496201. Epub 2019 Apr 10. PubMed PMID: 30970373; PubMed Central PMCID: PMC7353925. Download PDF
Chen Y, Cao K, Li J, Wang A, Sun L, Tang J, Xiong W, Zhou X, Chen X, Zhou J, Liu Y. Overexpression of long non-coding RNA NORAD promotes invasion and migration in malignant melanoma via regulating the MIR-205-EGLN2 pathway. Cancer Med. 2019 Apr;8(4):1744-1754. doi: 10.1002/cam4.2046. Epub 2019 Mar 7. PubMed PMID: 30843652; PubMed Central PMCID: PMC6488211. Download PDF
Hu F, Yan Y, Wang CW, Liu Y, Wang JJ, Zhou F, Zeng QH, Zhou X, Chen J, Wang AJ, Zhou JD. Article Effect and Mechanism of Ganoderma lucidum Polysaccharides on Human Fibroblasts and Skin Wound Healing in Mice. Chin J Integr Med. 2019 Mar;25(3):203-209. doi: 10.1007/s11655-018-3060-9. Epub 2018 Dec 15. PubMed PMID: 30552545. Download PDF
Li J, Chen J, Wang S, Li P, Zheng C, Zhou X, Tao Y, Chen X, Sun L, Wang A, Cao K, Tang S, Zhou J. Blockage of transferred exosome-shuttled miR-494 inhibits melanoma growth and metastasis. J Cell Physiol. 2019 Feb 5;. doi: 10.1002/jcp.28234. [Epub ahead of print] PubMed PMID: 30723916. Download PDF
Long C, Lankford L, Wang A. Stem cell-based in utero therapies for spina bifida: implications for neural regeneration. Neural Regen Res. 2019 Feb;14(2):260-261. doi: 10.4103/1673-5374.244786. PubMed PMID: 30531007; PubMed Central PMCID: PMC6301160. Download PDF
Gao K, Kumar P, Cortez-Toledo E, Hao D, Reynaga L, Rose M, Wang C, Farmer D, Nolta J, Zhou J, Zhou P, Wang A. Potential long-term treatment of hemophilia A by neonatal co-transplantation of cord blood-derived endothelial colony-forming cells and placental mesenchymal stromal cells. Stem Cell Res Ther. 2019 Jan 22;10(1):34. doi: 10.1186/s13287-019-1138-8. PubMed PMID: 30670078; PubMed Central PMCID: PMC6341603. Download PDF
Zhou Z, Jiang H, Tu K, Yu W, Zhang J, Hu Z, Zhang H, Hao D, Huang P, Wang J, Wang A, Xiao Z, He C. ANKHD1 is required for SMYD3 to promote tumor metastasis in hepatocellular carcinoma. J Exp Clin Cancer Res. 2019 Jan 15;38(1):18. doi: 10.1186/s13046-018-1011-0. PubMed PMID: 30646949; PubMed Central PMCID: PMC6332640. Download PDF
Zhang Z, Du J, Wang S, Shao L, Jin K, Li F, Wei B, Ding W, Fu P, van Dam H, Wang A, Jin J, Ding C, Yang B, Zheng M, Feng XH, Guan KL, Zhang L. OTUB2 Promotes Cancer Metastasis via Hippo-Independent Activation of YAP and TAZ. Mol Cell. 2019 Jan 3;73(1):7-21.e7. doi: 10.1016/j.molcel.2018.10.030. Epub 2018 Nov 21. PubMed PMID: 30472188. Download PDF
Vanover M, Pivetti C, Lankford L, Kumar P, Galganski L, Kabagambe S, Keller B, Becker J, Chen YJ, Chung K, Lee C, Paxton Z, Deal B, Goodman L, Anderson J, Jensen G, Wang A, Farmer D. High density placental mesenchymal stromal cells provide neuronal preservation and improve motor function following in utero treatment of ovine myelomeningocele. J Pediatr Surg. 2019 Jan;54(1):75-79. doi: 10.1016/j.jpedsurg.2018.10.032. Epub 2018 Oct 4. PubMed PMID: 30529115; PubMed Central PMCID: PMC6339576. Download PDF
2018
Zhang S, Rasai A, Wang Y, Xu J, Bannerman P, Erol D, Tsegaye D, Wang A, Soulika A, Zhan X, Guo F. The Stem Cell Factor Sox2 Is a Positive Timer of Oligodendrocyte Development in the Postnatal Murine Spinal Cord. Mol Neurobiol. 2018 Dec;55(12):9001-9015. doi: 10.1007/s12035-018-1035-7. Epub 2018 Apr 5. PubMed PMID: 29623612; PubMed Central PMCID: PMC6173662. Download PDF
Phan J, Kumar P, Hao D, Gao K, Farmer D, Wang A. Engineering mesenchymal stem cells to improve their exosome efficacy and yield for cell-free therapy. J Extracell Vesicles. 2018;7(1):1522236. doi: 10.1080/20013078.2018.1522236. eCollection 2018. Review. PubMed PMID: 30275938; PubMed Central PMCID: PMC6161586. Download PDF
Wang Q, Chen J, Wang A, Sun L, Qian L, Zhou X, Liu Y, Tang S, Chen X, Cheng Y, Cao K, Zhou J. Differentially expressed circRNAs in melanocytes and melanoma cells and their effect on cell proliferation and invasion. Oncol Rep. 2018 Apr;39(4):1813-1824. doi: 10.3892/or.2018.6263. Epub 2018 Feb 13. PubMed PMID: 29436673.
Ryzhuk V, Zeng XX, Wang X, Melnychuk V, Lankford L, Farmer D, Wang A. Human amnion extracellular matrix derived bioactive hydrogel for cell delivery and tissue engineering. Mater Sci Eng C Mater Biol Appl. 2018 Apr 1;85:191-202. doi: 10.1016/j.msec.2017.12.026. Epub 2017 Dec 21. PubMed PMID: 29407148; PubMed Central PMCID: PMC6353560. Download PDF
Zhang S, Zhu X, Gui X, Croteau C, Song L, Xu J, Wang A, Bannerman P, Guo F. Sox2 Is Essential for Oligodendroglial Proliferation and Differentiation during Postnatal Brain Myelination and CNS Remyelination. J Neurosci. 2018 Feb 14;38(7):1802-1820. doi: 10.1523/JNEUROSCI.1291-17.2018. Epub 2018 Jan 15. PubMed PMID: 29335358; PubMed Central PMCID: PMC5815459. Download PDF
Long C, Lankford L, Kumar P, Grahn R, Borjesson DL, Farmer D, Wang A. Isolation and characterization of canine placenta-derived mesenchymal stromal cells for the treatment of neurological disorders in dogs. Cytometry A. 2018 Jan;93(1):82-92. doi: 10.1002/cyto.a.23171. Epub 2017 Jul 17. PubMed PMID: 28715613.
Kumar P, Gao K, Wang C, Pivetti C, Lankford L, Farmer D, Wang A. In Utero Transplantation of Placenta-Derived Mesenchymal Stromal Cells for Potential Fetal Treatment of Hemophilia A. Cell Transplant. 2018 Jan;27(1):130-139. doi: 10.1177/0963689717728937. PubMed PMID: 29562772; PubMed Central PMCID: PMC6434487. Download PDF
Wang D, Li LK, Dai T, Wang A, Li S. Adult Stem Cells in Vascular Remodeling. Theranostics. 2018;8(3):815-829. doi: 10.7150/thno.19577. eCollection 2018. Review. PubMed PMID: 29344309; PubMed Central PMCID: PMC5771096. Download PDF
2017
Chang TY, Chen C, Lee M, Chang YC, Lu CH, Lu ST, Wang DY, Wang A, Guo CL, Cheng PL. Paxillin facilitates timely neurite initiation on soft-substrate environments by interacting with the endocytic machinery. Elife. 2017 Dec 22;6. doi: 10.7554/eLife.31101. PubMed PMID: 29271742; PubMed Central PMCID: PMC5768420. Download PDF
Huang CW, Huang WC, Qiu X, Fernandes Ferreira da Silva F, Wang A, Patel S, Nesti LJ, Poo MM, Li S. The Differentiation Stage of Transplanted Stem Cells Modulates Nerve Regeneration. Sci Rep. 2017 Dec 12;7(1):17401. doi: 10.1038/s41598-017-17043-4. PubMed PMID: 29234013; PubMed Central PMCID: PMC5727226. Download PDF
Kabagambe SK, Lankford L, Kumar P, Chen YJ, Herout KT, Lee CJ, Stark RA, Farmer DL, Wang A. Isolation of myogenic progenitor cell population from human placenta: A pilot study. J Pediatr Surg. 2017 Dec;52(12):2078-2082. doi: 10.1016/j.jpedsurg.2017.08.025. Epub 2017 Sep 4. PubMed PMID: 28964407. Download PDF
Chen YJ, Lankford L, Kabagambe S, Saenz Z, Kumar P, Farmer D, Wang A. Effect of 2-octylcyanoacrylate on placenta derived mesenchymal stromal cells on extracellular matrix. Placenta. 2017 Nov;59:163-168. doi: 10.1016/j.placenta.2017.03.022. Epub 2017 Apr 2. PubMed PMID: 28465002. Download PDF
Vanover M, Wang A, Farmer D. Potential clinical applications of placental stem cells for use in fetal therapy of birth defects. Placenta. 2017 Nov;59:107-112. doi: 10.1016/j.placenta.2017.05.010. Epub 2017 May 18. Review. PubMed PMID: 28651900. Download PDF
Cao K, Li J, Chen J, Qian L, Wang A, Chen X, Xiong W, Tang J, Tang S, Chen Y, Chen Y, Cheng Y, Zhou J. microRNA-33a-5p increases radiosensitivity by inhibiting glycolysis in melanoma. Oncotarget. 2017 Oct 13;8(48):83660-83672. doi: 10.18632/oncotarget.19014. eCollection 2017 Oct 13. PubMed PMID: 29137372; PubMed Central PMCID: PMC5663544. Download PDF
Chen YJ, Chung K, Pivetti C, Lankford L, Kabagambe SK, Vanover M, Becker J, Lee C, Tsang J, Wang A, Farmer DL. Fetal surgical repair with placenta-derived mesenchymal stromal cell engineered patch in a rodent model of myelomeningocele. J Pediatr Surg. 2017 Oct 12;. doi: 10.1016/j.jpedsurg.2017.10.040. [Epub ahead of print] PubMed PMID: 29096888. Download PDF
Liao JL, Chen J, He B, Chen Y, Xu JQ, Xie HJ, Hu F, Wang AJ, Luo C, Li QF, Zhou JD. Viability and Biomechanics of Diced Cartilage Blended With Platelet-Rich Plasma and Wrapped With Poly (Lactic-Co-Glycolic) Acid Membrane. J Craniofac Surg. 2017 Sep;28(6):1418-1424. doi: 10.1097/SCS.0000000000003739. PubMed PMID: 28692513. Download PDF
Wang D, Wu F, Yuan H, Wang A, Kang GJ, Truong T, Chen L, McCallion AS, Gong X, Li S. Sox10+ Cells Contribute to Vascular Development in Multiple Organs-Brief Report. Arterioscler Thromb Vasc Biol. 2017 Sep;37(9):1727-1731. doi: 10.1161/ATVBAHA.117.309774. Epub 2017 Jul 27. PubMed PMID: 28751573; PubMed Central PMCID: PMC5572822. Download PDF
Henry JJD, Yu J, Wang A, Lee R, Fang J, Li S. Engineering the mechanical and biological properties of nanofibrous vascular grafts for in situ vascular tissue engineering. Biofabrication. 2017 Aug 17;9(3):035007. doi: 10.1088/1758-5090/aa834b. PubMed PMID: 28817384; PubMed Central PMCID: PMC5847368. Download PDF
Lankford L, Chen YJ, Saenz Z, Kumar P, Long C, Farmer D, Wang A. Manufacture and preparation of human placenta-derived mesenchymal stromal cells for local tissue delivery. Cytotherapy. 2017 Jun;19(6):680-688. doi: 10.1016/j.jcyt.2017.03.003. Epub 2017 Apr 21. PubMed PMID: 28438482. Download PDF
Hao D, Xiao W, Liu R, Kumar P, Li Y, Zhou P, Guo F, Farmer DL, Lam KS, Wang F, Wang A. Discovery and Characterization of a Potent and Specific Peptide Ligand Targeting Endothelial Progenitor Cells and Endothelial Cells for Tissue Regeneration. ACS Chem Biol. 2017 Apr 21;12(4):1075-1086. doi: 10.1021/acschembio.7b00118. Epub 2017 Mar 2. PubMed PMID: 28195700; PubMed Central PMCID: PMC5875449. Download PDF
Harding A, Cortez-Toledo E, Magner NL, Beegle JR, Coleal-Bergum DP, Hao D, Wang A, Nolta JA, Zhou P. Highly Efficient Differentiation of Endothelial Cells from Pluripotent Stem Cells Requires the MAPK and the PI3K Pathways. Stem Cells. 2017 Apr;35(4):909-919. doi: 10.1002/stem.2577. Epub 2017 Mar 1. PubMed PMID: 28248004.
Wang D, Wang A, Wu F, Qiu X, Li Y, Chu J, Huang WC, Xu K, Gong X, Li S. Sox10+ adult stem cells contribute to biomaterial encapsulation and microvascularization. Sci Rep. 2017 Jan 10;7:40295. doi: 10.1038/srep40295. PubMed PMID: 28071739; PubMed Central PMCID: PMC5223127. Download PDF
2016
Brown EG, Keller BA, Lankford L, Pivetti CD, Hirose S, Farmer DL, Wang A. Age Does Matter: A Pilot Comparison of Placenta-Derived Stromal Cells for in utero Repair of Myelomeningocele Using a Lamb Model. Fetal Diagn Ther. 2016;39(3):179-85. doi: 10.1159/000433427. Epub 2015 Jul 7. PubMed PMID: 26159889. Download PDF
2015
Chen L, Ao Q, Sharma HS, Wang A, Feng S. Neurorestoratologic Strategies and Mechanisms in the Nervous System. Biomed Res Int. 2015;2015:163170. doi: 10.1155/2015/163170. Epub 2015 Sep 29. PubMed PMID: 26491655; PubMed Central PMCID: PMC4603317. Download PDF
Yu M, Sun ZJ, Li LT, Ge HY, Song CQ, Wang AJ. The beneficial effects of the herbal medicine Di-huang-yin-zi (DHYZ) on patients with ischemic stroke: A Randomized, Placebo controlled clinical study. Complement Ther Med. 2015 Aug;23(4):591-7. doi: 10.1016/j.ctim.2015.06.003. Epub 2015 Jun 19. PubMed PMID: 26275652. Download PDF
Wang A, Brown EG, Lankford L, Keller BA, Pivetti CD, Sitkin NA, Beattie MS, Bresnahan JC, Farmer DL. Placental mesenchymal stromal cells rescue ambulation in ovine myelomeningocele. Stem Cells Transl Med. 2015 Jun;4(6):659-69. doi: 10.5966/sctm.2014-0296. Epub 2015 Apr 24. PubMed PMID: 25911465; PubMed Central PMCID: PMC4449103. Download PDF
Brown EG, Keller BA, Pivetti CD, Sitkin NA, Wang A, Farmer DL, Bresnahan JC. Development of a locomotor rating scale for testing motor function in sheep. J Pediatr Surg. 2015 Apr;50(4):617-21. doi: 10.1016/j.jpedsurg.2015.01.002. Epub 2015 Jan 24. PubMed PMID: 25840074. Download PDF
Lankford L, Selby T, Becker J, Ryzhuk V, Long C, Farmer D, Wang A. Early gestation chorionic villi-derived stromal cells for fetal tissue engineering. World J Stem Cells. 2015 Jan 26;7(1):195-207. doi: 10.4252/wjsc.v7.i1.195. PubMed PMID: 25621120; PubMed Central PMCID: PMC4300931. Download PDF
Meierhenry J, Ryzhuk V, Miguelino M, Lankford L, Powell J, Farmer D, Wang A. Placenta as a Source of Stem Cells for Regenerative Medicine. Current Pathobiology Reports. 2015; 3(1):9-16. doi: 10.1007/s40139-015-0070-6.
2014
Xiang P, Wu KC, Zhu Y, Xiang L, Li C, Chen DL, Chen F, Xu G, Wang A, Li M, Jin ZB. A novel Bruch’s membrane-mimetic electrospun substrate scaffold for human retinal pigment epithelium cells. Biomaterials. 2014 Dec;35(37):9777-9788. doi: 10.1016/j.biomaterials.2014.08.040. Epub 2014 Sep 15. PubMed PMID: 25220295. Download PDF
Wei Y, Gong K, Ao Q, Wang A, Gong Y, Zuo H, Zhang Y, Wang J, Wang G. Lentiviral vectors enveloped with rabies virus glycoprotein can be used as a novel retrograde tracer to assess nerve recovery in rat sciatic nerve injury models. Cell Tissue Res. 2014 Feb;355(2):255-66. doi: 10.1007/s00441-013-1756-x. Epub 2013 Dec 11. PubMed PMID: 24326614. Download PDF
Brown EG, Saadai P, Pivetti CD, Beattie MS, Bresnahan JC, Wang A, Farmer DL. In utero repair of myelomeningocele with autologous amniotic membrane in the fetal lamb model. J Pediatr Surg. 2014 Jan;49(1):133-7; discussion 137-8. doi: 10.1016/j.jpedsurg.2013.09.043. Epub 2013 Oct 5. PubMed PMID: 24439597. Download PDF
2013
Xu W, Wang Y, Liu E, Sun Y, Luo Z, Xu Z, Liu W, Zhong L, Lv Y, Wang A, Tang Z, Li S, Yang L. Human iPSC-derived neural crest stem cells promote tendon repair in a rat patellar tendon window defect model. Tissue Eng Part A. 2013 Nov;19(21-22):2439-51. doi: 10.1089/ten.TEA.2012.0453. Epub 2013 Aug 9. PubMed PMID: 23815150; PubMed Central PMCID: PMC3807699. Download PDF
Lee BL, Tang Z, Wang A, Huang F, Yan Z, Wang D, Chu JS, Dixit N, Yang L, Li S. Synovial stem cells and their responses to the porosity of microfibrous scaffold. Acta Biomater. 2013 Jul;9(7):7264-75. doi: 10.1016/j.actbio.2013.03.009. Epub 2013 Mar 19. PubMed PMID: 23523935; PubMed Central PMCID: PMC3669641. Download PDF
Tang Z, Wang A, Wang D, Li S. Smooth muscle cells: to be or not to be? Response to Nguyen et Al. Circ Res. 2013 Jan 4;112(1):23-6. doi: 10.1161/CIRCRESAHA.112.281055. Epub 2012 Oct 23. PubMed PMID: 23093574. Download PDF
Saadai P, Wang A, Nout YS, Downing TL, Lofberg K, Beattie MS, Bresnahan JC, Li S, Farmer DL. Human induced pluripotent stem cell-derived neural crest stem cells integrate into the injured spinal cord in the fetal lamb model of myelomeningocele. J Pediatr Surg. 2013 Jan;48(1):158-63. doi: 10.1016/j.jpedsurg.2012.10.034. PubMed PMID: 23331809. Download PDF
2012
Yu J, Wang A, Tang Z, Henry J, Li-Ping Lee B, Zhu Y, Yuan F, Huang F, Li S. The effect of stromal cell-derived factor-1α/heparin coating of biodegradable vascular grafts on the recruitment of both endothelial and smooth muscle progenitor cells for accelerated regeneration. Biomaterials. 2012 Nov;33(32):8062-74. doi: 10.1016/j.biomaterials.2012.07.042. Epub 2012 Aug 11. PubMed PMID: 22884813; PubMed Central PMCID: PMC3488434. Download PDF
Downing TL, Wang A, Yan ZQ, Nout Y, Lee AL, Beattie MS, Bresnahan JC, Farmer DL, Li S. Drug-eluting microfibrous patches for the local delivery of rolipram in spinal cord repair. J Control Release. 2012 Aug 10;161(3):910-7. doi: 10.1016/j.jconrel.2012.05.034. Epub 2012 May 23. PubMed PMID: 22634093; PubMed Central PMCID: PMC3698241. Download PDF
Lee BL, Jeon H, Wang A, Yan Z, Yu J, Grigoropoulos C, Li S. Femtosecond laser ablation enhances cell infiltration into three-dimensional electrospun scaffolds. Acta Biomater. 2012 Jul;8(7):2648-58. doi: 10.1016/j.actbio.2012.04.023. Epub 2012 Apr 19. PubMed PMID: 22522128; PubMed Central PMCID: PMC3425609. Download PDF
Tang Z, Wang A, Yuan F, Yan Z, Liu B, Chu JS, Helms JA, Li S. Differentiation of multipotent vascular stem cells contributes to vascular diseases. Nat Commun. 2012 Jun 6;3:875. doi: 10.1038/ncomms1867. PubMed PMID: 22673902; PubMed Central PMCID: PMC3538044. Download PDF
2011
Saadai P, Nout YS, Encinas J, Wang A, Downing TL, Beattie MS, Bresnahan JC, Li S, Farmer DL. Prenatal repair of myelomeningocele with aligned nanofibrous scaffolds-a pilot study in sheep. J Pediatr Surg. 2011 Dec;46(12):2279-83. doi: 10.1016/j.jpedsurg.2011.09.014. PubMed PMID: 22152865. Download PDF
Hsu S, Chu JS, Chen FF, Wang A, Li S. Effects of Fluid Shear Stress on a Distinct Population of Vascular Smooth Muscle Cells. Cell Mol Bioeng. 2011 Dec;4(4):627-636. doi: 10.1007/s12195-011-0205-8. PubMed PMID: 22924082; PubMed Central PMCID: PMC3425612. Download PDF
Li X, Chu J, Wang A, Zhu Y, Chu WK, Yang L, Li S. Uniaxial mechanical strain modulates the differentiation of neural crest stem cells into smooth muscle lineage on micropatterned surfaces. PLoS One. 2011;6(10):e26029. doi: 10.1371/journal.pone.0026029. Epub 2011 Oct 7. PubMed PMID: 22016804; PubMed Central PMCID: PMC3189240. Download PDF
Wang A, Tang Z, Park IH, Zhu Y, Patel S, Daley GQ, Li S. Induced pluripotent stem cells for neural tissue engineering. Biomaterials. 2011 Aug;32(22):5023-32. doi: 10.1016/j.biomaterials.2011.03.070. Epub 2011 Apr 22. PubMed PMID: 21514663; PubMed Central PMCID: PMC3100451. Download PDF
Wei Y, Gong K, Zheng Z, Wang A, Ao Q, Gong Y, Zhang X. Chitosan/silk fibroin-based tissue-engineered graft seeded with adipose-derived stem cells enhances nerve regeneration in a rat model. J Mater Sci Mater Med. 2011 Aug;22(8):1947-64. doi: 10.1007/s10856-011-4370-z. Epub 2011 Jun 8. PubMed PMID: 21656031. Download PDF
Zhu Y, Wang A, Patel S, Kurpinski K, Diao E, Bao X, Kwong G, Young WL, Li S. Engineering bi-layer nanofibrous conduits for peripheral nerve regeneration. Tissue Eng Part C Methods. 2011 Jul;17(7):705-15. doi: 10.1089/ten.tec.2010.0565. Epub 2011 Apr 18. PubMed PMID: 21501089; PubMed Central PMCID: PMC3124110. Download PDF
Park JS, Chu JS, Tsou AD, Diop R, Tang Z, Wang A, Li S. The effect of matrix stiffness on the differentiation of mesenchymal stem cells in response to TGF-β. Biomaterials. 2011 Jun;32(16):3921-30. doi: 10.1016/j.biomaterials.2011.02.019. PubMed PMID: 21397942; PubMed Central PMCID: PMC3073995. Download PDF
2010
Wei Y, Gong K, Zheng Z, Liu L, Wang A, Zhang L, Ao Q, Gong Y, Zhang X. Schwann-like cell differentiation of rat adipose-derived stem cells by indirect co-culture with Schwann cells in vitro. Cell Prolif. 2010 Dec;43(6):606-16. doi: 10.1111/j.1365-2184.2010.00710.x. PubMed PMID: 21039999; PubMed Central PMCID: PMC6496385. Download PDF
Wang G, Ao Q, Gong K, Wang A, Zheng L, Gong Y, Zhang X. The effect of topology of chitosan biomaterials on the differentiation and proliferation of neural stem cells. Acta Biomater. 2010 Sep;6(9):3630-9. doi: 10.1016/j.actbio.2010.03.039. Epub 2010 Apr 3. PubMed PMID: 20371303. Download PDF
Lam HJ, Patel S, Wang A, Chu J, Li S. In vitro regulation of neural differentiation and axon growth by growth factors and bioactive nanofibers. Tissue Eng Part A. 2010 Aug;16(8):2641-8. doi: 10.1089/ten.TEA.2009.0414. PubMed PMID: 20367289; PubMed Central PMCID: PMC2947452. Download PDF
Zhu Y, Wang A, Shen W, Patel S, Zhang R, Young W, Li S. Nanofibrous Patches for Spinal Cord Regeneration. Adv Funct Mater. 2010 May 10;20(9):1433-1440. doi: 10.1002/adfm.200901889. Epub 2010 Mar 17. PubMed PMID: 23378825; PubMed Central PMCID: PMC3558949. Download PDF
2009
Wei Y, Zhou J, Zheng Z, Wang A, Ao Q, Gong Y, Zhang X. An improved method for isolating Schwann cells from postnatal rat sciatic nerves. Cell Tissue Res. 2009 Sep;337(3):361-9. doi: 10.1007/s00441-009-0836-4. Epub 2009 Jul 29. PubMed PMID: 19639342. Download PDF
Zheng Z, Zhang L, Kong L, Wang A, Gong Y, Zhang X. The behavior of MC3T3-E1 cells on chitosan/poly-L-lysine composite films: effect of nanotopography, surface chemistry, and wettability. J Biomed Mater Res A. 2009 May;89(2):453-65. doi: 10.1002/jbm.a.31979. PubMed PMID: 18431777. Download PDF
Zheng Z, Wei Y, Wang G, Wang A, Ao Q, Zhang X. Surface Properties of Chitosan Films Modified with Polycations and Their Effects on the Behavior of PC12 Cells. Journal of Bioactive and Compatible Polymers. 2009; 24(1):63-82. doi: 10.1177/0883911508099653. Download PDF
2008
Zhou F, Zhang L, Wang A, Song B, Gong K, Zhang L, Hu M, Zhang X, Zhao N, Gong Y. The association of GSK3 beta with E2F1 facilitates nerve growth factor-induced neural cell differentiation. J Biol Chem. 2008 May 23;283(21):14506-15. doi: 10.1074/jbc.M706136200. Epub 2008 Mar 26. PubMed PMID: 18367454. Download PDF
Zhou F, Zhang L, Gong K, Lu G, Sheng B, Wang A, Zhao N, Zhang X, Gong Y. LEF-1 activates the transcription of E2F1. Biochem Biophys Res Commun. 2008 Jan 4;365(1):149-53. doi: 10.1016/j.bbrc.2007.10.138. Epub 2007 Oct 31. PubMed PMID: 17980157. Download PDF
2007
Wang A, Ao Q, Wei Y, Gong K, Liu X, Zhao N, Gong Y, Zhang X. Physical properties and biocompatibility of a porous chitosan-based fiber-reinforced conduit for nerve regeneration. Biotechnol Lett. 2007 Nov;29(11):1697-702. doi: 10.1007/s10529-007-9460-0. Epub 2007 Jul 13. PubMed PMID: 17628751. Download PDF
Kong L, Ao Q, Wang A, Gong K, Wang X, Lu G, Gong Y, Zhao N, Zhang X. Preparation and characterization of a multilayer biomimetic scaffold for bone tissue engineering. J Biomater Appl. 2007 Nov;22(3):223-39. doi: 10.1177/0885328206073706. Epub 2007 Jan 25. PubMed PMID: 17255157. Download PDF
Ao Q, Wang AJ, Chen GQ, Wang SJ, Zuo HC, Zhang XF. Combined transplantation of neural stem cells and olfactory ensheathing cells for the repair of spinal cord injuries. Med Hypotheses. 2007;69(6):1234-7. doi: 10.1016/j.mehy.2007.04.011. Epub 2007 Jun 4. PubMed PMID: 17548168. Download PDF
He Q, Ao Q, Wang A, Gong Y, Zhao N, Zhang X. In Vitro Cytotoxicity and Protein Drug Release Properties of Chitosan/Heparin Microspheres. Tsinghua Science and Technology. 2007; 12(4):361-365. doi: 10.1007/s40139-015-0070-6. Download PDF
2006
Ao Q, Sun XH, Wang AJ, Fu PF, Gong K, Zuo HC, Gong YD, Zhang XF. Protective effects of extract of Ginkgo biloba (EGb 761) on nerve cells after spinal cord injury in rats. Spinal Cord. 2006 Nov;44(11):662-7. doi: 10.1038/sj.sc.3101900. Epub 2006 Jan 17. PubMed PMID: 16415923. Download PDF
Wang A, Ao Q, Cao W, Yu M, He Q, Kong L, Zhang L, Gong Y, Zhang X. Porous chitosan tubular scaffolds with knitted outer wall and controllable inner structure for nerve tissue engineering. J Biomed Mater Res A. 2006 Oct;79(1):36-46. doi: 10.1002/jbm.a.30683. PubMed PMID: 16758450. Download PDF
Qi H, Hu P, Xu J, Wang A. Encapsulation of drug reservoirs in fibers by emulsion electrospinning: morphology characterization and preliminary release assessment. Biomacromolecules. 2006 Aug;7(8):2327-30. doi: 10.1021/bm060264z. PubMed PMID: 16903678. Download PDF
Zhang L, Ao Q, Wang A, Lu G, Kong L, Gong Y, Zhao N, Zhang X. A sandwich tubular scaffold derived from chitosan for blood vessel tissue engineering. J Biomed Mater Res A. 2006 May;77(2):277-84. doi: 10.1002/jbm.a.30614. PubMed PMID: 16400655. Download PDF
Ao Q, Wang A, Cao W, Zhang L, Kong L, He Q, Gong Y, Zhang X. Manufacture of multimicrotubule chitosan nerve conduits with novel molds and characterization in vitro. J Biomed Mater Res A. 2006 Apr;77(1):11-8. doi: 10.1002/jbm.a.30593. PubMed PMID: 16345091. Download PDF
Wang A, Ao Q, He Q, Gong X, Gong K, Gong Y, Zhao N, Zhang X. Neural Stem Cell Affinity of Chitosan and Feasibility of Chitosan-based Porous Conduits as Scaffolds for Nerve Tissue Engineering. Tsinghua Science and Technology. 2006; 11(4):415-420. doi: 10.1177/0883911508099653. Download PDF
2005
Ao Q, Wang A, Cao W, Zhao C, Gong Y, Zhao N, Zhang X. Preparation of Porous Multi-channeled Chitosan Conduits for Nerve Tissue Engineering. Key Engineering Materials. 2005; 288-289:27-30. doi: 10.4028/www.scientific.net/KEM.288-289.27. Download PDF
Cao W, Wang A, Jing D, Gong Y, Zhao N, Zhang X. Novel biodegradable films and scaffolds of chitosan blended with poly(3-hydroxybutyrate). J Biomater Sci Polym Ed. 2005;16(11):1379-94. doi: 10.1163/156856205774472308. PubMed PMID: 16370239.
Ao Q, Wang A, Cao W, Zhao C, Gong Y, Zhao N, Zhang X. Fabrication and Characterization of Chitosan Nerve Conduits with Microtubular Architecture. Tsinghua Science and Technology. 2005; 10(4):435-438. doi: 10.4028/www.scientific.net/KEM.288-289.27. Download PDF
Wang A, Ao Q, Cao W, Zhao C, Gong Y, Zhao N, Zhang X. Fiber-based Chitosan Tubular Scaffolds for Soft Tissue Engineering: Fabrication and in vitro Evaluation. Tsinghua Science and Technology. 2005; 10(4):449-453. doi: 10.1016/S1007-0214(05)70099-7.