Members
Yan Wang
Assistant Investigator
2425 Stockton Blvd, Room 601
Sacramento, CA 95817
(916) 453-2265
yyawang (at) ucdavis.edu
Education
- Ph.D. Pharmacology, China Pharmaceutical University
- Post-Doc, Neurology, University of California, Davis
Research Interests
Glial cells development, glial-glial cross-talk, myelination and remyelination in the CNS diseases
Our research aims to investigate the generation and differentiation of distinct glial cell subtypes (oligodendrocytes, astrocytes and microglia) during the CNS development and demyelinating diseases. We are also investigating the role of cross-talk between microglia activation and oligodendrocytes remyelination in the pathogenesis of multiple sclerosis. We study the development and injury of glial cells using a variety of molecular and cellular approaches in combination with in vivo animal models and in vitro primary cultures. Our research goal is to understand the molecular mechanisms of demyelinating diseases and develop effective therapies through promoting myelin repair and regulating the interaction of microglia and oligodendrocytes.
2020
Hull V, Wang Y, Burns T, Zhang S, Sternbach S, McDonough J, Guo F, Pleasure D. Antisense Oligonucleotide Reverses Leukodystrophy in Canavan Disease Mice. Ann Neurol. 2020 Mar;87(3):480-485. doi: 10.1002/ana.25674. Epub 2020 Jan 22. PMID: 31925837. Download PDF
Pleasure D, Guo F, Chechneva O, Bannerman P, McDonough J, Burns T, Wang Y, Hull V. Pathophysiology and Treatment of Canavan Disease. Neurochem Res. 2020 Mar;45(3):561-565. doi: 10.1007/s11064-018-2693-6. Epub 2018 Dec 8. PMID: 30535831. Download PDF
Zhang S, Kim B, Zhu X, Gui X, Wang Y, Lan Z, Prabhu P, Fond K, Wang A, Guo F. Glial type specific regulation of CNS angiogenesis by HIFα-activated different signaling pathways. Nat Commun. 2020 Apr 24;11(1):2027. doi: 10.1038/s41467-020-15656-4. PMID: 32332719; PMCID: PMC7181614. Download PDF
Wang G, Wang T, Hu Y, Wang J, Wang Y, Zhang Y, Li F, Liu W, Sun Y, Yu B, Kou J. NMMHC IIA triggers neuronal autophagic cell death by promoting F-actin-dependent ATG9A trafficking in cerebral ischemia/reperfusion. Cell Death Dis. 2020 Jun 8;11(6):428. doi: 10.1038/s41419-020-2639-1. PMID: 32513915; PMCID: PMC7280511. Download PDF
2019
Clark K, Zhang S, Barthe S, Kumar P, Pivetti C, Kreutzberg N, Reed C, Wang Y, Paxton Z, Farmer D, Guo F, Wang A. Placental Mesenchymal Stem Cell-Derived Extracellular Vesicles Promote Myelin Regeneration in an Animal Model of Multiple Sclerosis. Cells. 2019 Nov 23;8(12):1497. doi: 10.3390/cells8121497. PMID: 31771176; PMCID: PMC6952942. Download PDF
2018
Zhang S, Rasai A, Wang Y, Xu J, Bannerman P, Erol D, Tsegaye D, Wang A, Soulika A, Zhan X, Guo F. The Stem Cell Factor Sox2 Is a Positive Timer of Oligodendrocyte Development in the Postnatal Murine Spinal Cord. Mol Neurobiol. 2018 Dec;55(12):9001-9015. doi: 10.1007/s12035-018-1035-7. Epub 2018 Apr 5. PMID: 29623612; PMCID: PMC6173662. Download PDF
Bannerman P, Guo F, Chechneva O, Burns T, Zhu X, Wang Y, Kim B, Singhal NK, McDonough JA, Pleasure D. Brain Nat8l Knockdown Suppresses Spongiform Leukodystrophy in an Aspartoacylase-Deficient Canavan Disease Mouse Model. Mol Ther. 2018 Mar 7;26(3):793-800. doi: 10.1016/j.ymthe.2018.01.002. Epub 2018 Jan 10. PMID: 29456021; PMCID: PMC5910673. Download PDF
2017
Wang Y, Xu Y, Liu Q, Zhang Y, Gao Z, Yin M, Jiang N, Cao G, Yu B, Cao Z, Kou J. Myosin IIA-related Actomyosin Contractility Mediates Oxidative Stress-induced Neuronal Apoptosis. Front Mol Neurosci. 2017 Mar 14;10:75. doi: 10.3389/fnmol.2017.00075. PMID: 28352215; PMCID: PMC5348499. Download PDF
Xu Y, Wang Y, Wang G, Ye X, Zhang J, Cao G, Zhao Y, Gao Z, Zhang Y, Yu B, Kou J. YiQiFuMai Powder Injection Protects against Ischemic Stroke via Inhibiting Neuronal Apoptosis and PKCδ/Drp1-Mediated Excessive Mitochondrial Fission. Oxid Med Cell Longev. 2017;2017:1832093. doi: 10.1155/2017/1832093. Epub 2017 Dec 24. PMID: 29435096; PMCID: PMC5757147. Download PDF
2016
Cao GS, Li SX, Wang Y, Xu YQ, Lv YN, Kou JP, Yu BY. A combination of four effective components derived from Sheng-mai san attenuates hydrogen peroxide-induced injury in PC12 cells through inhibiting Akt and MAPK signaling pathways. Chin J Nat Med. 2016 Jul;14(7):508-17. doi: 10.1016/S1875-5364(16)30060-7. PMID: 27507201. Download PDF
Wang Y, Liu Q, Xu Y, Zhang Y, Lv Y, Tan Y, Jiang N, Cao G, Ma X, Wang J, Cao Z, Yu B, Kou J. Ginsenoside Rg1 Protects against Oxidative Stress-induced Neuronal Apoptosis through Myosin IIA-actin Related Cytoskeletal Reorganization. Int J Biol Sci. 2016 Oct 25;12(11):1341-1356. doi: 10.7150/ijbs.15992. PMID: 27877086; PMCID: PMC5118780. Download PDF
2015
Shen K, Wang Y, Zhang Y, Zhou H, Song Y, Cao Z, Kou J, Yu B. Cocktail of Four Active Components Derived from Sheng Mai San Inhibits Hydrogen Peroxide-Induced PC12 Cell Apoptosis Linked with the Caspase-3/ROCK1/MLC Pathway. Rejuvenation Res. 2015 Dec;18(6):517-27. doi: 10.1089/rej.2015.1697. Epub 2015 Sep 29. PMID: 26058543. Download PDF
Zhai K, Tang Y, Zhang Y, Li F, Wang Y, Cao Z, Yu J, Kou J, Yu B. NMMHC IIA inhibition impedes tissue factor expression and venous thrombosis via Akt/GSK3β-NF-κB signalling pathways in the endothelium. Thromb Haemost. 2015 Jul;114(1):173-85. doi: 10.1160/TH14-10-0880. Epub 2015 Apr 16. PMID: 25881103; PMCID: PMC5993197. Download PDF