Members
Verónica Martínez Cerdeño
Investigator, Shriners Hospitals for Children
Professor, Department of Pathology & Laboratory Medicine, University of California, Davis
2425 Stockton Blvd, Room 671, Sacramento, CA 95817
(916) 453-2163
vmartinezcerdeno (at) ucdavis.edu
Education
- Complutense University, Madrid, Spain B.S. 1993-98 Biology
- Autonóma University of Madrid, Spain Ph.D. 1998-02 Neuroscience
- Columbia University, NY Postdoctoral training 2002-04 Brain Development
- University of California, San Francisco Postdoctoral training 2004-07 Brain Development
- University of California, Davis, M.I.N.D. Institute, Postdoctoral training 2007-08 Autism
Research Interests
The goal of Dr. Martínez-Cerdeño’s laboratory is to determine the etiology and the pathology of some forms of autism. In addition, we study the role of stem cells in the development, evolution, and pathogenesis of the mammalian cerebral cortex. We study the anatomy and pathology of autism and related diseases in postmortem brains and based on our finding we develop animal models for autism research. Animal model mimicking our findings in human provide an excellent tool to generate and test new treatment for different kinds of autism.
We investigate the pathology, anatomy, and histology of postmortem tissue from subjects with autism and related disorders, including Fragile X Syndrome, and Fragile X-associated tremor/ataxia syndrome (FXTAS). Our most recent discovery is that parvalbumin-expressing interneurons are reduced in discrete areas of the prefrontal cortex in autism. This discovery suggests that a deficit of inhibition acting on pyramidal neurons may contribute to the cognitive phenotype of autism. This brings us a step closer to a fuller understanding of the cellular basis of autism and to the development of new therapeutic interventions. We also developed an autoimmune mouse model of autism based on prenatal exposure to maternal antibodies. In this animal model of autism, we have shown that the anatomy of the cerebral cortex is altered by the administration of human maternal auto-antibodies during prenatal development. We found that the prenatal exposure to maternal antibodies produces behavioral changes in offspring and increased the size of neurons in the cerebral cortex. Other significant contributions in our laboratory include the discovery of an iron metabolism deficit in FXTAS, and the fact that FTXAS pathology develops in early adulthood, not late in life as previously thought.
Cortical evolution has long been one of Dr. Martínez Cerdeño’s dearest interests. Our research in cortical evolution has focused on the transition from three-layered lissencephalic cortex to six-layered gyrencephalic cortex, from both an evolutionary and a developmental perspective. One of our most notable contributions to this field was the introduction of the concept of a “two-step hypothesis of cortical evolution”. This hypothesis posits that the production of excitatory cortical neurons takes place trough a two-step process where radial glial cells produce IP cells, which then generate cortical neurons. We have provided evidence that this process evolved very early in the vertebrate brain, perhaps at the divergence of mammals and reptiles. Furthermore, we propose that this mechanism of cell generation is responsible for the expansion of the cerebral cortex that took place in mammalian evolution. Since formulating this hypothesis we have published multiple papers adding novel information that corroborate the role of the two-step process of neurogenesis in the evolution of the mammalian cerebral cortex. Our interest in cortical evolution led us to establish and organize the “Cortical Evolution 2015” Conference.
For more information please visit my websites at: www.Ventricular.Org
2021
Falcone C, McBride EL, Hopkins WD, Hof PR, Manger PR, Sherwood CC, Noctor CS, Martínez-Cerdeño V. Redefining varicose projection astrocytes in primates. Glia. 2021 Sep 17. doi: 10.1002/glia.24093. PMID:34533866. Download PDF
Salcedo-Arellano MJ, Sanchez D, Wang JY, McLennan YA, Clark CJ, Juarez P, Schneider A, Tassone F, Hagerman RJ, Martinez-Cerdeno V. Coexistence of Alzheimer-type Neuropathology in Fragile X-associated Tremor Ataxia Syndrome. Frontiers in Neuroscience 17 September. Download PDF
Falcone C, Mevises N, Hong T, Dufour B, Chen X, Noctor SC, Martínez-Cerdeño V. Neuronal and glial cell number is altered in a cortical layer-specific manner in autism. (2021) Autism. Download PDF
Salcedo-Arellano MJ, Wang JY, McLennan YA, Doan M, Cabal-Herrera AM, Jimenez S, Wolf-Ochoa MW, Sanchez D, Juarez P, Tassone F, Durbin-Johnson B, Hagerman RJ, Martínez-Cerdeño V. Cerebral Microbleeds in Fragile X-Associated Tremor/Ataxia Syndrome. Cereb Cortex. Mov Disord. 2021 Mar 24. doi: 10.1002/mds.28559. PMID: 33760253. Download PDF
Amina S, Falcone C, Hong T, Wolf-Ochoa MW, Vakilzadeh G, Allen E, Perez Castro R, Karger M, Noctor S, Martínez Cerdeño V. Chandelier cartridge density is reduced in the prefrontal cortex in autism. Cerebral Cortex. Feb 1:bhaa402. doi: 10.1093/cercor/bhaa402. Download PDF
Dufour B, Amina S, Martinez Cerdeño V. FXTAS presents with upregulation of the cytokines IL12 and TNF alpha. Parkinsonism & Related Disorders. Jan;82:117-120. doi: 10.1016/j.parkreldis.2020.11.026. Download PDF
Falcone C, Penna E, Hong T, Tarantal AF, Hof PR, Hopkins WD, Sherwood CC, Noctor SC, Martínez-Cerdeño V. Cortical Interlaminar Astrocytes are Generated Prenatally, Mature Postnatally, and Express Unique Markers in Human and Nonhuman Primates. Cerebral Cortex. Jan 1;31(1):379-395. doi: 10.1093/cercor/bhaa231. Download PDF
2020
Salcedo-Arellano MJ, Wolf-Ochoa MW, Hong T, Amina S, Tassone F, Lechpammer M, Hagerman R, Martínez-Cerdeño V. Parkinsonism Versus Concomitant Parkinson’s Disease in Fragile X-Associated Tremor/Ataxia Syndrome. Mov Disord Clin Pract. 2020 Apr 9;7(4):413-418. doi: 10.1002/mdc3.12942. PMID: 32373658; PMCID: PMC7197312. Download PDF
Hong T, Falcone C, Dufour B, Amina S, Castro RP, Regalado J, Pearson W, Noctor SC, Martínez-Cerdeño V. GABAARα2 is Decreased in the Axon Initial Segment of Pyramidal Cells in Specific Areas of the Prefrontal Cortex in Autism. Neuroscience. 2020 Jun 15;437:76-86. doi: 10.1016/j.neuroscience.2020.04.025. Epub 2020 Apr 23. PMID: 32335215.
Falcone C, Vakilzadeh G, Noctor SC, Martínez-Cerdeño V. The fundamental building blocks of cortical development are established in human exencephaly. Pediatr Res. 2020 Apr;87(5):868-871. doi: 10.1038/s41390-019-0687-y. Epub 2019 Nov 29. PMID: 31783397. Download PDF
2019
Salcedo-Arellano MJ, Hagerman RJ, Martinez-Cerdeno V. Sindrome de temblor y ataxia asociado al X fragil: presentacion clinica, patologia y tratamiento [Fragile X associated tremor/ataxia syndrome: its clinical presentation, pathology, and treatment]. Rev Neurol. 2019 Mar 1;68(5):199-206. doi: 10.33588/rn.6805.2018457. PMID: 30805918; PMCID: PMC7001878.
Falcone C, Wolf-Ochoa M, Amina S, Hong T, Vakilzadeh G, Hopkins WD, Hof PR, Sherwood CC, Manger PR, Noctor SC, Martínez-Cerdeño V. Cortical interlaminar astrocytes across the therian mammal radiation. J Comp Neurol. 2019 Jul 1;527(10):1654-1674. doi: 10.1002/cne.24605. Epub 2019 Jan 25. PMID: 30552685; PMCID: PMC6465161. Download PDF
2018
Liu F, Horton-Sparks K, Hull V, Li RW, Martínez-Cerdeño V. The valproic acid rat model of autism presents with gut bacterial dysbiosis similar to that in human autism. Mol Autism. 2018 Dec 10;9:61. doi: 10.1186/s13229-018-0251-3. PMID: 30555669; PMCID: PMC6288876. Download PDF
Martínez-Cerdeño V, Noctor SC. Cortical evolution 2018: Advantages of animal model species. J Comp Neurol. 2019 Jul 1;527(10):1766-1768. doi: 10.1002/cne.24536. Epub 2018 Nov 11. PMID: 30394535. Download PDF
Martínez Cerdeño V, Hong T, Amina S, Lechpammer M, Ariza J, Tassone F, Noctor SC, Hagerman P, Hagerman R. Microglial cell activation and senescence are characteristic of the pathology FXTAS. Mov Disord. 2018 Dec;33(12):1887-1894. doi: 10.1002/mds.27553. Epub 2018 Dec 10. PMID: 30537011; PMCID: PMC6413690. Download PDF
Martínez-Cerdeño V, Camacho J, Ariza J, Rogers H, Horton-Sparks K, Kreutz A, Behringer R, Rasweiler JJ 4th, Noctor SC. The Bat as a New Model of Cortical Development. Cereb Cortex. 2018 Nov 1;28(11):3880-3893. doi: 10.1093/cercor/bhx251. PMID: 29136119; PMCID: PMC6454483. Download PDF
Ariza J, Rogers H, Hashemi E, Noctor SC, Martínez-Cerdeño V. The Number of Chandelier and Basket Cells Are Differentially Decreased in Prefrontal Cortex in Autism. Cereb Cortex. 2018 Feb 1;28(2):411-420. doi: 10.1093/cercor/bhw349. PMID: 28122807; PMCID: PMC6676950. Download PDF
2017
Martínez-Cerdeño V, García-Moreno F, Tosches MA, Csillag A, Manger PR, Molnár Z. Update on forebrain evolution: From neurogenesis to thermogenesis. Semin Cell Dev Biol. 2018 Apr;76:15-22. doi: 10.1016/j.semcdb.2017.09.034. Epub 2017 Oct 21. PMID: 28964836; PMCID: PMC5866743. Download PDF
Martínez-Cerdeño V, Barrilleaux BL, McDonough A, Ariza J, Yuen BTK, Somanath P, Le CT, Steward C, Horton-Sparks K, Knoepfler PS. Behavior of Xeno-Transplanted Undifferentiated Human Induced Pluripotent Stem Cells Is Impacted by Microenvironment Without Evidence of Tumors. Stem Cells Dev. 2017 Oct 1;26(19):1409-1423. doi: 10.1089/scd.2017.0059. Epub 2017 Aug 22. PMID: 28693365; PMCID: PMC5647528. Download PDF
Martínez-Cerdeño V, Lechpammer M, Hagerman PJ, Hagerman R. Two FMR1 premutation cases without nuclear inclusions. Mov Disord. 2017 Sep;32(9):1328-1329. doi: 10.1002/mds.27060. Epub 2017 Jun 1. PMID: 28568317; PMCID: PMC5714313. Download PDF
Ariza J, Hurtado J, Rogers H, Ikeda R, Dill M, Steward C, Creary D, Van de Water J, Martínez-Cerdeño V. Maternal autoimmune antibodies alter the dendritic arbor and spine numbers in the infragranular layers of the cortex. PLoS One. 2017 Aug 18;12(8):e0183443. doi: 10.1371/journal.pone.0183443. PMID: 28820892; PMCID: PMC5562324. Download PDF
Ariza J, Rogers H, Hartvigsen A, Snell M, Dill M, Judd D, Hagerman P, Martínez-Cerdeño V. Iron accumulation and dysregulation in the putamen in fragile X-associated tremor/ataxia syndrome. Mov Disord. 2017 Apr;32(4):585-591. doi: 10.1002/mds.26902. Epub 2017 Feb 24. PMID: 28233916; PMCID: PMC5714315. Download PDF
Martínez-Cerdeño V, Lechpammer M, Noctor S, Ariza J, Hagerman P, Hagerman R. FMR1 premutation with Prader-Willi phenotype and fragile X-associated tremor/ataxia syndrome. Clin Case Rep. 2017 Mar 23;5(5):625-629. doi: 10.1002/ccr3.834. PMID: 28469864; PMCID: PMC5412812. Download PDF
Martínez-Cerdeño V. Dendrite and spine modifications in autism and related neurodevelopmental disorders in patients and animal models. Dev Neurobiol. 2017 Apr;77(4):393-404. doi: 10.1002/dneu.22417. Epub 2016 Aug 30. PMID: 27390186; PMCID: PMC5219951. Download PDF
Hashemi E, Ariza J, Rogers H, Noctor SC, Martínez-Cerdeño V. The Number of Parvalbumin-Expressing Interneurons Is Decreased in the Prefrontal Cortex in Autism. Cereb Cortex. 2017 Mar 1;27(3):1931-1943. doi: 10.1093/cercor/bhw021. Erratum in: Cereb Cortex. 2018 Feb 1;28(2):690. PMID: 26922658; PMCID: PMC6074948. Download PDF
2016
Ariza J, Rogers H, Monterrubio A, Reyes-Miranda A, Hagerman PJ, Martínez-Cerdeño V. A Majority of FXTAS Cases Present with Intranuclear Inclusions Within Purkinje Cells. Cerebellum. 2016 Oct;15(5):546-51. doi: 10.1007/s12311-016-0776-y. PMID: 27108270. Download PDF
Hashemi E, Ariza J, Lechpammer M, Noctor SC, Martínez-Cerdeño V. Abnormal white matter tracts resembling pencil fibers involving prefrontal cortex (Brodmann area 47) in autism: a case report. J Med Case Rep. 2016 Aug 26;10(1):237. doi: 10.1186/s13256-016-1020-6. PMID: 27562638; PMCID: PMC5000439. Download PDF
Rogers H, Ariza J, Monterrubio A, Hagerman P, Martínez-Cerdeño V. Cerebellar Mild Iron Accumulation in a Subset of FMR1 Premutation Carriers with FXTAS. Cerebellum. 2016 Oct;15(5):641-4. doi: 10.1007/s12311-016-0798-5. PMID: 27259564; PMCID: PMC5014668. Download PDF
Martínez-Cerdeño V, Noctor SC. Cortical evolution 2015: Discussion of neural progenitor cell nomenclature. J Comp Neurol. 2016 Feb 15;524(3):704-9. doi: 10.1002/cne.23909. Epub 2015 Nov 23. PMID: 26439982; PMCID: PMC4706766. Download PDF
Martínez-Cerdeño V, Cunningham CL, Camacho J, Keiter JA, Ariza J, Lovern M, Noctor SC. Evolutionary origin of Tbr2-expressing precursor cells and the subventricular zone in the developing cortex. J Comp Neurol. 2016 Feb 15;524(3):433-47. doi: 10.1002/cne.23879. Epub 2015 Sep 8. PMID: 26267763; PMCID: PMC4843790. Download PDF
Martínez-Cerdeño V, Camacho J, Fox E, Miller E, Ariza J, Kienzle D, Plank K, Noctor SC, Van de Water J. Prenatal Exposure to Autism-Specific Maternal Autoantibodies Alters Proliferation of Cortical Neural Precursor Cells, Enlarges Brain, and Increases Neuronal Size in Adult Animals. Cereb Cortex. 2016 Jan;26(1):374-383. doi: 10.1093/cercor/bhu291. Epub 2014 Dec 22. PMID: 25535268; PMCID: PMC4677982. Download PDF
2015
Martínez-Cerdeño V, Lechpammer M, Lott A, Schneider A, Hagerman R. Fragile X-Associated Tremor/Ataxia Syndrome in a Man in His 30s. JAMA Neurol. 2015 Sep;72(9):1070-3. doi: 10.1001/jamaneurol.2015.1138. PMID: 26368352; PMCID: PMC4629842. Download PDF
Kim E, Camacho J, Combs Z, Ariza J, Lechpammer M, Noctor SC, Martínez-Cerdeño V. Preliminary findings suggest the number and volume of supragranular and infragranular pyramidal neurons are similar in the anterior superior temporal area of control subjects and subjects with autism. Neurosci Lett. 2015 Mar 4;589:98-103. doi: 10.1016/j.neulet.2015.01.021. Epub 2015 Jan 9. PMID: 25582788; PMCID: PMC4336808. Download PDF
McDonough A, Monterrubio A, Ariza J, Martínez-Cerdeño V. Calibrated forceps model of spinal cord compression injury. J Vis Exp. 2015 Apr 24;(98):52318. doi: 10.3791/52318. PMID: 25938880; PMCID: PMC4541603. Download PDF
2014
Ariza J, Steward C, Rueckert F, Widdison M, Coffman R, Afjei A, Noctor SC, Hagerman R, Hagerman P, Martínez-Cerdeño V. Dysregulated iron metabolism in the choroid plexus in fragile X-associated tremor/ataxia syndrome. Brain Res. 2015 Feb 19;1598:88-96. doi: 10.1016/j.brainres.2014.11.058. Epub 2014 Dec 9. PMID: 25498860; PMCID: PMC4340768. Download PDF
Martínez-Cerdeño V, Noctor SC. Cajal, Retzius, and Cajal-Retzius cells. Front Neuroanat. 2014 Jun 17;8:48. doi: 10.3389/fnana.2014.00048. PMID: 24987337; PMCID: PMC4060955. Download PDF
Camacho J, Ejaz E, Ariza J, Noctor SC, Martínez-Cerdeño V. RELN-expressing neuron density in layer I of the superior temporal lobe is similar in human brains with autism and in age-matched controls. Neurosci Lett. 2014 Sep 5;579:163-7. doi: 10.1016/j.neulet.2014.07.031. Epub 2014 Jul 25. PMID: 25067827; PMCID: PMC4324637. Download PDF
Camacho J, Jones K, Miller E, Ariza J, Noctor S, de Water JV, Martínez-Cerdeño V. Embryonic intraventricular exposure to autism-specific maternal autoantibodies produces alterations in autistic-like stereotypical behaviors in offspring mice. Behav Brain Res. 2014 Jun 1;266:46-51. doi: 10.1016/j.bbr.2014.02.045. Epub 2014 Mar 5. PMID: 24613242; PMCID: PMC4075424. Download PDF