- B.A. English Literature, Reed College, Portland, OR 1989
- Ph.D. Molecular Pathology, UCSD, Mark Kamps Lab 1998
- Post-Doc, Bob Eisenman Lab, Fred Hutchinson CRC
The Knoepfler Lab conducts developmental biology, stem cell, and cancer research with a focus on chromatin and epigenetic mechanisms. We are particularly interested in regulation of normal brain growth and how epigenomic programming goes awry in childhood brain tumors and microcephaly.
The Knoepfler Lab is interested in epigenetics and chromatin, and the cellular machinery that regulates these states normally in stem cells and aberrantly in cancer, particularly pediatric brain tumors, as well as during faulty brain development such as occurs with microcephaly. There are many, exciting open questions in these areas of research. For instance, what are the shared and distinct molecular events in normal and cancer stem cells? Do some of these same molecules impact brain growth in microcephaly? What about childhood brain tumors?
We use cutting edge molecular, cellular and developmental biology methods including brain organoids as well as genomic and gene editing technologies to attack these questions. We are particularly interested now in the roles that the histone variant H3.3 and MYC family factors play in stem cells and cancer. How do these factors link together the epigenome to cellular behaviors and tissue growth?
Our big picture goal is to impact human health through discoveries in development, cancer and stem cell biology. Join us! We are currently as of 2018 looking for a talented postdoctoral fellow to join our team, and we are always recruiting new graduate and undergraduate students as well.
Also, please see Dr. Knoepfler’s independent lab page for more information.
Dr. Knoepfler runs a regenerative medicine blog, The Niche.