Members
Fuzheng Guo
Associate Professor, Dept. Of Neurology, University of California, Davis
Associate Investigator
2425 Stockton Blvd., RM 672, Sacramento, CA 95817
(916) 453-5026
fzguo@ucdavis.edu
Education
- 2000 B.S. in Biology – Henan normal University, China
- 2006 Ph.D. in Cellular and Molecular Biology – Beijing Normal University, China
Research Interests
Neural development; Glial differentiation, myelination and remyelination in neurological disorders and animal models; Glia-Vascular Interrelations
Our laboratory is currently studying how oligodendrocyte differentiation, myelination and remyelination are regulated during normal development and dysregulated in neurological disorders. Previous studies from our laboratory and others have shown that a signaling pathway called canonical Wnt/β-catenin signaling inhibits oligodendrocyte differentiation. TCF7l2, a known transcription factor mediating Wnt/β-catenin activity in Wnt responsive cells such as colorectal cancer cells, is postulated to inhibit oligodendrocyte differentiation and myelination through Wnt/β-catenin signaling. However, genetic data from both our laboratory and others suggest that TCF7l2 is an intrinsic positive regulator of oligodendrocyte development. Further genetic evidence from our laboratory indicates that TCF7l2 regulates postnatal oligodendrocyte development in a manner independent of Wnt/β-catenin signaling and that TCF7l2 promotes oligodendrocyte differentiation in demyelination animal models. Our study shifts the research direction of this transcription factor from a postulated myelination inhibitor to a positive regulator during oligodendrocyte development. The second project in our laboratory is studying interaction between oligodendroglia and vascular cells during normal CNS development and in neuroinflammatory diseases and the molecular basis for this interaction. Other projects in our lab are focused on transcriptional control of astroglial development and activation after neural injury. Please visit our laboratory website at Guo Laboratory Website.
2018
Sox2 Is Essential for Oligodendroglial Proliferation and Differentiation during Postnatal Brain Myelination and CNS Remyelination. J Neurosci. 2018 02 14; 38(7):1802-1820.Zhang S, Zhu X, Gui X, Croteau C, Song L, Xu J, Wang A, Bannerman P, Guo F. PMID: 29335358. Download PDF
Brain Nat8l Knockdown Suppresses Spongiform Leukodystrophy in an Aspartoacylase-Deficient Canavan Disease Mouse Model. Mol Ther. 2018 03 07; 26(3):793-800.Bannerman P, Guo F, Chechneva O, Burns T, Zhu X, Wang Y, Kim B, Singhal NK, McDonough JA, Pleasure D. PMID: 29456021. Download PDF
2017
Discovery and Characterization of a Potent and Specific Peptide Ligand Targeting Endothelial Progenitor Cells and Endothelial Cells for Tissue Regeneration. ACS Chem Biol. 2017 04 21; 12(4):1075-1086.Hao D, Xiao W, Liu R, Kumar P, Li Y, Zhou P, Guo F, Farmer DL, Lam KS, Wang F, Wang A. PMID: 28195700. Download PDF
Suppressing N-Acetyl-l-Aspartate Synthesis Prevents Loss of Neurons in a Murine Model of Canavan Leukodystrophy. J Neurosci. 2017 01 11; 37(2):413-421.Sohn J, Bannerman P, Guo F, Burns T, Miers L, Croteau C, Singhal NK, McDonough JA, Pleasure D. PMID: 28077719.
The neuronal metabolite NAA regulates histone H3 methylation in oligodendrocytes and myelin lipid composition. Exp Brain Res. 2017 01; 235(1):279-292.Singhal NK, Huang H, Li S, Clements R, Gadd J, Daniels A, Kooijman EE, Bannerman P, Burns T, Guo F, Pleasure D, Freeman E, Shriver L, McDonough J. PMID: 27709268. Download PDF
2016
Rationale and Methodology of Reprogramming for Generation of Induced Pluripotent Stem Cells and Induced Neural Progenitor Cells. Int J Mol Sci. 2016 Apr 20; 17(4).Tian Z, Guo F, Biswas S, Deng W. PMID: 27104529. Download PDF
2015
Chronological protein synthesis in regenerating rat liver. Electrophoresis. 2015 Jul; 36(14):1622-32.He J, Hao S, Zhang H, Guo F, Huang L, Xiao X, He D. PMID: 25873423.
The Wnt effector transcription factor 7-like 2 positively regulates oligodendrocyte differentiation in a manner independent of Wnt/ß-catenin signaling. J Neurosci. 2015 Mar 25; 35(12):5007-22.Hammond E, Lang J, Maeda Y, Pleasure D, Angus-Hill M, Xu J, Horiuchi M, Deng W, Guo F. PMID: 25810530. Download PDF
Canonical Wnt signaling in the oligodendroglial lineage–puzzles remain. Glia. 2015 Oct; 63(10):1671-93.Guo F, Lang J, Sohn J, Hammond E, Chang M, Pleasure D. PMID: 25782433. Download PDF
The subventricular zone continues to generate corpus callosum and rostral migratory stream astroglia in normal adult mice. J Neurosci. 2015 Mar 04; 35(9):3756-63.Sohn J, Orosco L, Guo F, Chung SH, Bannerman P, Mills Ko E, Zarbalis K, Deng W, Pleasure D. PMID: 25740506. Download PDF
2014
Deletion of astroglial CXCL10 delays clinical onset but does not affect progressive axon loss in a murine autoimmune multiple sclerosis model. J Neuroinflammation. 2014 Jun 12; 11:105.Mills Ko E, Ma JH, Guo F, Miers L, Lee E, Bannerman P, Burns T, Ko D, Sohn J, Soulika AM, Pleasure D. PMID: 24924222. Download PDF
Conditional ablation of astroglial CCL2 suppresses CNS accumulation of M1 macrophages and preserves axons in mice with MOG peptide EAE. J Neurosci. 2014 Jun 11; 34(24):8175-85.Moreno M, Bannerman P, Ma J, Guo F, Miers L, Soulika AM, Pleasure D. PMID: 24920622. Download PDF
Stress and glucocorticoids promote oligodendrogenesis in the adult hippocampus. Mol Psychiatry. 2014 Dec; 19(12):1275-1283.Chetty S, Friedman AR, Taravosh-Lahn K, Kirby ED, Mirescu C, Guo F, Krupik D, Nicholas A, Geraghty A, Krishnamurthy A, Tsai MK, Covarrubias D, Wong A, Francis D, Sapolsky RM, Palmer TD, Pleasure D, Kaufer D. PMID: 24514565. Download PDF
2013
Olig2/Plp-positive progenitor cells give rise to Bergmann glia in the cerebellum. Cell Death Dis. 2013 Mar 14; 4:e546.Chung SH, Guo F, Jiang P, Pleasure DE, Deng W. PMID: 23492777. Download PDF
Adenomatous polyposis coli regulates oligodendroglial development. J Neurosci. 2013 Feb 13; 33(7):3113-30.Lang J, Maeda Y, Bannerman P, Xu J, Horiuchi M, Pleasure D, Guo F. PMID: 23407966. Download PDF
Origins and significance of astrogliosis in the multiple sclerosis model, MOG peptide EAE. J Neurol Sci. 2013 Oct 15; 333(1-2):55-9.Moreno M, Guo F, Mills Ko E, Bannerman P, Soulika A, Pleasure D. PMID: 23294494. Download PDF
2012
PEDF is a novel oligodendrogenic morphogen acting on the adult SVZ and corpus callosum. J Neurosci. 2012 Aug 29; 32(35):12152-64.Sohn J, Selvaraj V, Wakayama K, Orosco L, Lee E, Crawford SE, Guo F, Lang J, Horiuchi M, Zarbalis K, Itoh T, Deng W, Pleasure D. PMID: 22933798. Download PDF
Disruption of NMDA receptors in oligodendroglial lineage cells does not alter their susceptibility to experimental autoimmune encephalomyelitis or their normal development. J Neurosci. 2012 Jan 11; 32(2):639-45.Guo F, Maeda Y, Ko EM, Delgado M, Horiuchi M, Soulika A, Miers L, Burns T, Itoh T, Shen H, Lee E, Sohn J, Pleasure D. PMID: 22238099. Download PDF
2011
Triple labeling with three thymidine analogs reveals a well-orchestrated regulation of hepatocyte proliferation during liver regeneration. Hepatol Res. 2011 Dec; 41(12):1230-9.Wu Y, Guo F, Liu J, Xiao X, Huang L, He D. PMID: 21917088. Download PDF
Macroglial plasticity and the origins of reactive astroglia in experimental autoimmune encephalomyelitis. J Neurosci. 2011 Aug 17; 31(33):11914-28.Guo F, Maeda Y, Ma J, Delgado M, Sohn J, Miers L, Ko EM, Bannerman P, Xu J, Wang Y, Zhou C, Takebayashi H, Pleasure D. PMID: 21849552. Download PDF
2010
Pyramidal neurons are generated from oligodendroglial progenitor cells in adult piriform cortex. J Neurosci. 2010 Sep 08; 30(36):12036-49.Guo F, Maeda Y, Ma J, Xu J, Horiuchi M, Miers L, Vaccarino F, Pleasure D. PMID: 20826667. Download PDF
2009
Early postnatal proteolipid promoter-expressing progenitors produce multilineage cells in vivo. J Neurosci. 2009 Jun 03; 29(22):7256-70.Guo F, Ma J, McCauley E, Bannerman P, Pleasure D. PMID: 19494148. Download PDF
2008
A high-temporal resolution technology for dynamic proteomic analysis based on 35S labeling. PLoS One. 2008 Aug 20; 3(8):e2991.Zhang Z, Chen J, Guo F, He L, Wu Y, Zeng C, Xiao X, He D. PMID: 18714357. Download PDF
2006
Proteomic analysis of the transition from quiescent to proliferating stages in rat liver hepatectomy model. Proteomics. 2006 May; 6(10):3075-86.Guo F, Nian H, Zhang H, Huang L, Tang Y, Xiao X, He D. PMID: 16619303. Download PDF
2004
Discovery of laryngeal carcinoma by serum proteomic pattern analysis. Sci China C Life Sci. 2004 Jun; 47(3):219-23.Xiao X, Zhao X, Liu J, Guo F, Liu D, He D. PMID: 15524278.
2003
Development of proteomic patterns for detecting lung cancer. Dis Markers. 2003-2004; 19(1):33-9.Xiao X, Liu D, Tang Y, Guo F, Xia L, Liu J, He D. PMID: 14757945. Download PDF