Yan Wang Photo

Yan Wang

Assistant Investigator
2425 Stockton Blvd, Room 601
Sacramento, CA 95817
(916) 453-2265
yyawang (at)


  • Ph.D. Pharmacology, China Pharmaceutical University
  • Post-Doc, Neurology, University of California, Davis

Research Interests

Glial cells development, glial-glial cross-talk, myelination and remyelination in the CNS diseases

Our research aims to investigate the generation and differentiation of distinct glial cell subtypes (oligodendrocytes, astrocytes and microglia) during the CNS development and demyelinating diseases. We are also investigating the role of cross-talk between microglia activation and oligodendrocytes remyelination in the pathogenesis of multiple sclerosis. We study the development and injury of glial cells using a variety of molecular and cellular approaches in combination with in vivo animal models and in vitro primary cultures. Our research goal is to understand the molecular mechanisms of demyelinating diseases and develop effective therapies through promoting myelin repair and regulating the interaction of microglia and oligodendrocytes.

Antisense oligonucleotide reverses leukodystrophy in Canavan disease mice. Ann Neurol. 2020,87(3):480-485. doi: 10.1002/ana.25674. PMID: 31925837 Hull V, Wang Y, Burns T, Zhang S, Sternbach S, McDonough J, Guo F, Pleasure D. 2020 HTML PDF
Pathophysiology and treatment of Canavan disease. Neurochem Res. 2020,45(3):561-565. doi: 10.1007/s11064-018-2693-6. PMID: 30535831 Pleasure D, Guo F, Chechneva O, Bannerman P, McDonough J, Burns T, Wang Y, Hull V. 2020 HTML PDF
Glial type specific regulation of CNS angiogenesis by HIFα-activated different signaling pathways Zhang S, Kim B, Zhu X, Gui X, Wang Y, Lan Z, Prabhu P, Fond K, Wang A, Guo F. 2020 HTML PDF
NMMHC IIA triggers neuronal autophagic cell death by promoting F-actin-dependent ATG9A trafficking in cerebral ischemia/reperfusion. Nat Commun. 2020,24;11(1):2027. doi: 10.1038/s41467-020-15656-4. PMID: 32332719 Wang G, Wang T, Hu Y, Wang J, Wang Y, Zhang Y, Li F, Liu W, Sun Y, Yu B, Kou J. 2020 HTML PDF
Placental mesenchymal stem cell-derived extracellular vesicles promote myelin regeneration in an animal model of multiple sclerosis. Cells. 2019,23;8(12):1497. doi: 10.3390/cells8121497. PMID: 31771176 Clark K, Zhang S, Barthe S, Kumar P, Pivetti C, Kreutzberg N, Reed C, Wang Y, Paxton Z, Farmer D, Guo F, Wang A 2019 HTML PDF
The stem cell factor sox2 is a positive timer of oligodendrocyte development in the postnatal murine spinal cord. Mol Neurobiol. 2018,55(12):9001-9015. doi: 10.1007/s12035-018-1035-7. PMID: 29623612 Zhang S, Rasai A, Wang Y, Xu J, Bannerman P, Erol D, Tsegaye D, Wang A, Soulika A, Zhan X, Guo F 2018 HTML PDF
Brain Nat8l knockdown suppresses spongiform leukodystrophy in an aspartoacylase-deficient Canavan disease mouse model. Mol Ther. 2018,7;26(3):793-800. doi: 10.1016/j.ymthe.2018.01.002. PMID: 29456021 Bannerman P, Guo F, Chechneva O, Burns T, Zhu X, Wang Y, Kim B, Singhal NK, McDonough JA, Pleasure D 2018 HTML PDF
Myosin IIA-related actomyosin contractility mediates oxidative stress-induced neuronal apoptosis. Front Mol Neurosci. 2017,14;10:75. doi: 10.3389/fnmol.2017.00075. PMID: 28352215 Wang Y, Xu Y, Liu Q, Zhang Y, Gao Z, Yin M, Jiang N, Cao G, Yu B, Cao Z, Kou J 2017 HTML PDF
YiQiFuMai powder injection protects against ischemic stroke via inhibiting neuronal apoptosis and PKCδ/Drp1-mediated excessive mitochondrial fission. Oxid Med Cell Longev. 2017;2017:1832093. doi: 10.1155/2017/1832093. PMID: 29435096 Xu Y, Wang Y, Wang G, Ye X, Zhang J, Cao G, Zhao Y, Gao Z, Zhang Y, Yu B, Kou J 2017 HTML PDF
A combination of four effective components derived from Sheng-mai san attenuates hydrogen peroxide-induced injury in PC12 cells through inhibiting Akt and MAPK signaling pathways. Chin J Nat Med. 2016,14(7):508-17. doi: 10.1016/S1875-5364(16)30060-7. PMID: 27507201 Cao G, Li S, Wang Y, Xu Y, Lv Y, Kou J, Yu B 2016 HTML PDF
Ginsenoside Rg1 protects against oxidative stress-induced neuronal apoptosis through myosin IIA-actin related cytoskeletal reorganization. Int J Biol Sci. 2016,25;12(11):1341-1356. doi: 10.7150/ijbs.15992. PMID: 27877086 Wang Y, Liu Q, Xu Y, Zhang Y, Lv Y, Tan Y, Jiang N, Cao G, Ma X, Wang J, Cao Z, Yu B, Kou J 2016 HTML PDF
Cocktail of four active components derived from Sheng Mai San inhibits hydrogen peroxide-induced PC12 cell apoptosis linked with the caspase-3/ROCK1/MLC pathway. Rejuvenation Res. 2015,18(6):517-27. doi: 10.1089/rej.2015.1697. PMID: 26058543 Shen K, Wang Y, Zhang Y, Zhou H, Song Y, Cao Z, Kou J, Yu B 2015 HTML PDF
NMMHC IIA inhibition impedes tissue factor expression and venous thrombosis via Akt/GSK3β-NF-κB signalling pathways in the endothelium. Thromb Haemost. 2015 Jul;114(1):173-85. doi: 10.1160/TH14-10-0880. PMID: 25881103 Zhai K, Tang Y, Zhang Y, Li F, Wang Y, Cao Z, Yu J, Kou J, Yu B 2015 HTML PDF