- Ph.D. Pharmacology, China Pharmaceutical University
- Post-Doc, Neurology, University of California, Davis
Glial cells development, glial-glial cross-talk, myelination and remyelination in the CNS diseases
Our research aims to investigate the generation and differentiation of distinct glial cell subtypes (oligodendrocytes, astrocytes and microglia) during the CNS development and demyelinating diseases. We are also investigating the role of cross-talk between microglia activation and oligodendrocytes remyelination in the pathogenesis of multiple sclerosis. We study the development and injury of glial cells using a variety of molecular and cellular approaches in combination with in vivo animal models and in vitro primary cultures. Our research goal is to understand the molecular mechanisms of demyelinating diseases and develop effective therapies through promoting myelin repair and regulating the interaction of microglia and oligodendrocytes.