Members

Paul Knoepfler Photo

Paul Knoepfler

Professor
2425 Stockton Blvd, Sacramento, CA 95817
(916) 453-2289
knoepfler (at) ucdavis.edu

Education

  • B.A. English Literature, Reed College, Portland, OR 1989
  • Ph.D. Molecular Pathology, UCSD, Mark Kamps Lab 1998
  • Post-Doc, Bob Eisenman Lab, Fred Hutchinson CRC

Research Interests

The Knoepfler Lab conducts developmental biology, stem cell, and cancer research with a focus on chromatin and epigenetic mechanisms. We are particularly interested in regulation of normal brain growth and how epigenomic programming goes awry in childhood brain tumors and microcephaly.

The Knoepfler Lab is interested in epigenetics and chromatin, and the cellular machinery that regulates these states normally in stem cells and aberrantly in cancer, particularly pediatric brain tumors, as well as during faulty brain development such as occurs with microcephaly. There are many, exciting open questions in these areas of research. For instance, what are the shared and distinct molecular events in normal and cancer stem cells? Do some of these same molecules impact brain growth in microcephaly? What about childhood brain tumors?

We use cutting edge molecular, cellular and developmental biology methods including brain organoids as well as genomic and gene editing technologies to attack these questions. We are particularly interested now in the roles that the histone variant H3.3 and MYC family factors play in stem cells and cancer. How do these factors link together the epigenome to cellular behaviors and tissue growth?

Our big picture goal is to impact human health through discoveries in development, cancer and stem cell biology. Join us! We are currently as of 2018 looking for a talented postdoctoral fellow to join our team, and we are always recruiting new graduate and undergraduate students as well.

Also, please see Dr. Knoepfler’s independent lab page for more information.

Dr. Knoepfler runs a regenerative medicine blog, The Niche.

TITLEAUTHOR(s)YEARDOWNLOAD
Rapid change of a cohort of 570 unproven stem cell clinics in the USA over 3 years. Regen Med. 2019 Aug 28. doi: 10.2217/rme-2019-0064. [Epub ahead of print] PMID: 31456478Knoepfler PS.2019HTML
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Gene editing: sloppy definitions mislead. Nature. 2018 Dec;564(7736):345. doi: 10.1038/d41586-018-07802-2. No abstract available. PMID: 30568213Knoepfler P.2019HTML
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Mapping and driving the stem cell ecosystem. Regen Med. 2018 Oct;13(7):845-858. doi: 10.2217/rme-2018-0056. Epub 2018 Oct 5. PMID: 30289055Knoepfler PS.2019HTML
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Genomic functions of developmental pluripotency associated factor 4 (Dppa4) in pluripotent stem cells and cancer. Stem Cell Res. 2018 Jul 19;31:83-94. doi: 10.1016/j.scr.2018.07.009. [Epub ahead of print]Klein RH, Tung PY, Somanath P, Fehling HJ, Knoepfler PS.2018HTML
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Too Much Carrot and Not Enough Stick in New Stem Cell Oversight Trends. Cell Stem Cell. 2018 Jul 5;23(1):18-20. doi: 10.1016/j.stem.2018.06.004. Epub 2018 Jun 21.Knoepfler PS.2018HTML
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The FDA and the US direct-to-consumer marketplace for stem cell interventions: a temporal analysis. Regen Med. 2018 Jan 12. doi: 10.2217/rme-2017-0115. [Epub ahead of print]Knoepfler PS, Turner LG.,2018HTML
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ERBB3-Binding Protein (EBP1) is a novel DPPA4 cofactor in human pluripotent cells. Stem Cells. 2018 Jan 12. doi: 10.1002/stem.2776. [Epub ahead of print]Somanath P, Bush KM, Knoepfler PS.,2018HTML
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CRISPR-mediated HDAC2 disruption identifies two distinct classes of target genes in human cells. PLOS. 2017 October 5, https://doi.org/10.1371/journal.pone.0185627Priyanka Somanath, Rachel Herndon Klein, Paul S. Knoepfler.2017HTML
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Behavior of xeno-transplanted undifferentiated human induced pluripotent stem cells is impacted by microenvironment without evidence of tumors. Stem Cells Dev. 2017 Jul 10. doi: 10.1089/scd.2017.0059.Martinez-Cerdeno V, Barrilleaux B, McDonough A, Ariza J, Yuen B, Somanath P, Le C, Steward C, Horton K, Knoepfler P.2017HTML
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Selling Stem Cells in the USA: Assessing the Direct-to-Consumer Industry. Cell Stem Cell. 2016 Jun 29. pii: S1934-5909(16)30157-6. doi: 10.1016/j.stem.2016.06.007. [Epub ahead of print] PubMed PMID: 27374789.Turner L, Knoepfler P.2016HTML
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Review of Stem Cell Dialogues by Sheldon Krimsky(1). Am J Bioeth. 2016 Apr;16(4):W12-3. doi: 10.1080/15265161.2016.1145756.Knoepfler PS.2016 
When patients reach out, scientists should reach back carefully. Nat Med. 2016 Mar 3;22(3):230. doi: 10.1038/nm0316-230.Knoepfler PS.2016HTML
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Reviewing post-publication peer review. Trends Genet. 2015 May;31(5):221-3. doi: 10.1016/j.tig.2015.03.006. Epub 2015 Apr 4.Knoepfler P.2015HTML
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From bench to FDA to bedside: US regulatory trends for new stem cell therapies. Adv Drug Deliv Rev. 2015 Mar;82-83C:192-196. doi: 10.1016/j.addr.2014.12.001. Epub 2014 Dec 7. Review.Knoepfler PS.2015HTML
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Histone H3.3 regulates dynamic chromatin states during spermatogenesis. Development. 2014 Aug 19. pii: dev.106450. [Epub ahead of print]Yuen BT, Bush KM, Barrilleaux BL, Cotterman R, Knoepfler PS.2014HTML
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Miz-1 Activates Gene Expression via a Novel Consensus DNA Binding Motif.. Barrilleaux BL, Burow D, Lockwood SH, Yu A, Segal DJ, Knoepfler PS. PLoS One. 2014 Jul 1;9(7):e101151. doi: 10.1371/journal.pone.0101151. eCollection 2014. 2014HTML
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Epigenetic mechanisms of tumorigenicity manifesting in stem cells.. Oncogene. 2014 Jun 16;0. doi: 10.1038/onc.2014.172. [Epub ahead of print]Tung PY, Knoepfler PS.2014HTML
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Histone H3.3 Mutations: A Variant Path to Cancer. Cancer cell 24 (5), 567-574.BTK Yuen, PS Knoepfler.2013HTML
Identification of DPPA4 and DPPA2 as a Novel Family of Pluripotency‐Related Oncogenes. STEM CELLS 31 (11), 2330-2342.PY Tung, NV Varlakhanova, PS Knoepfler.2013HTML
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Key Action Items for the Stem Cell Field: Looking Ahead to 2014. Stem cells and development.PS Knoepfler.2013HTML
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Scientists: you really need to get out of the lab more. Nat Med. 2013 Sep 6;19(9):1086. doi: 10.1038/nm0913-1086.Knoepfler PS.2013HTML
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Chromatin immunoprecipitation assays for myc and N-myc. The Myc Gene, 117-133.Barrilleaux BL, Cotterman R, Knoepfler PS.2013HTML
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Automation of Library Preparation for High-resolution ChIP-seq Profiling. I Journal of Biomolecular Techniques. 2013. JBT 24 (Suppl), S45.M Henry, R Cotterman, P Knoepfler, L Comai, RW Kim, H O’Geen.2013HTML
Myc binds the pluripotency factor Utf1 through the basic-helix-loop-helix leucine zipper domain. BBRC 2013 In Press.Laskowski AI and Knoepfler PS.2013HTML
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Endogenous mammalian histone H3.3 exhibits chromatin-related functions during development. Epigenetics Chromatin. 2013 Apr 9;6(1):7.Bush KM, Yuen BT, Barrilleaux BL, Riggs JW, O Geen H, Cotterman R, Knoepfler PS.2013HTML
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Induced pluripotency and oncogenic transformation are related processes. Stem Cells & Dev. 2013 Jan 1;22(1):37-50.Riggs JW,
Barrilleaux B,
Varlakhanova N,
Bush K,
Chan V,
and Knoepfler PS.2013HTML
Call for fellowship programs in stem cell-based regenerative and cellular medicine: new stem cell training is essential for physicians. Regen Med. 2013 Mar;8(2):223-5.Knoepfler PS.2013HTML