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Fuzheng Guo Photo

Fuzheng Guo

Associate Professor, Dept. Of Neurology, University of California, Davis
Associate Investigator
2425 Stockton Blvd., RM 672, Sacramento, CA 95817
(916) 453-5026
fzguo@ucdavis.edu

Education

  • 2000 B.S. in Biology – Henan normal University, China
  • 2006 Ph.D. in Cellular and Molecular Biology – Beijing Normal University, China

Research Interests

Neural development; Glial differentiation, myelination and remyelination in neurological disorders and animal models; Glia-Vascular Interrelations

The Anntena of an astrocyte (phaloidin staining)
The Anntena of an astrocyte (phaloidin staining)

Our laboratory is currently studying how oligodendrocyte differentiation, myelination and remyelination are regulated during normal development and dysregulated in neurological disorders. Previous studies from our laboratory and others have shown that a signaling pathway called canonical Wnt/β-catenin signaling inhibits oligodendrocyte differentiation. TCF7l2, a known transcription factor mediating Wnt/β-catenin activity in Wnt responsive cells such as colorectal cancer cells, is postulated to inhibit oligodendrocyte differentiation and myelination through Wnt/β-catenin signaling. However, genetic data from both our laboratory and others suggest that TCF7l2 is an intrinsic positive regulator of oligodendrocyte development. Further genetic evidence from our laboratory indicates that TCF7l2 regulates postnatal oligodendrocyte development in a manner independent of Wnt/β-catenin signaling and that TCF7l2 promotes oligodendrocyte differentiation in demyelination animal models. Our study shifts the research direction of this transcription factor from a postulated myelination inhibitor to a positive regulator during oligodendrocyte development. The second project in our laboratory is studying interaction between oligodendroglia and vascular cells during normal CNS development and in neuroinflammatory diseases and the molecular basis for this interaction. Other projects in our lab are focused on transcriptional control of astroglial development and activation after neural injury. Please visit our laboratory website at Guo Laboratory Website.

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Sox2 is essential for oligodendroglial proliferation and differentiation during postnatal brain myelination and CNS remyelination. J Neurosci 1291-17. doi: 10.1523/JNEUROSCI.1291-17.2018. [Epub ahead of print]Zhang S, Zhu X, Gui X, Croteau C, Song L, Xu J, Wang A, Bannerman P, Guo F.2018HTML
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Brain Nat8l knockdown suppresses spongiform leukodystrophy in an aspartoacylase-deficient Canavan disease mouse model. Molecular Therapy. DOI: https://doi.org/10.1016/j.ymthe.2018.01.002Bannerman P*, Guo F*, Chechneva O, Burns T, Zhu X, Wang Y, Kim B, Singhal N, McDonough J. Pleasure D. (* co-first authors)2018HTML
Discovery and Characterization of a Potent and Specific Peptide Ligand Targeting Endothelial Progenitor Cells and Endothelial Cells for Tissue Regeneration. ACS Chem Biol. 2017 Apr 21;12(4):1075-1086.Hao D, Xiao W, Liu R, Kumar P, Li Y, Zhou P, Guo F, Farmer DL, Lam KS, Wang F, Wang A.2017HTML
Suppressing N-acetyl-L-aspartate (NAA) synthesis prevents loss of neurons in a murine model of Canavan leukodystrophy. J NeurosciSohn J*, Bannerman P*, Guo F*, Burns T, Miers L, Croteau C, Singhal NK, McDonough JA, Pleasure D. (* co-first authors)2016HTML
The neuronal metabolite NAA regulates histone H3 methylation in oligodendrocytes and myelin lipid composition. Exp Brain Res.Singhal NK, Huang H, Li S, Clements R, Gadd J, Daniels A, Kooijman EE, Bannerman P, Burns T, Guo F,
Pleasure D, Freeman E, Shriver L, McDonough J
2016HTML
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Rationale and methodology of reprogramming for generation of
induced pluripotent stem cells and induced neural progenitor cells. Int J Mol Sci.
Tian Z, Guo F, Biswas S, Deng W2016HTML
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The Wnt effector TCF7l2 positively regulates oligodendrocyte differentiation in a manner independent of Wnt/beta-catenin signaling. J Neurosci (In press)Hammond H, Lang J, Maeda Y, Pleasure D, Angus-Hill M, Xu J, Horiuchi M, Deng W and Guo F2015 
Canonical Wnt signaling in the oligodendroglial lineage–puzzles remain. Glia (In press)Guo F, Lang J, Sohn J, Hammond B, Chang M, Pleasure D.2015 
Ablating N-acetylaspartate prevents leukodystrophy in a Canavan disease model. Annals of Neurology (In press)Guo F, Bannerman P, KO EM, Miers L, Xu J, Burns T, Li S, Freeman E, McDonough J and Pleasure D2015 
The subventricular zone continues to generate corpus callosum and rostral migratory stream astroglia in normal adult mice. J Neurosci (In press)Sohn J, Orosco L, Guo F, Chung S, Bannerman P, Ko EM, Zarbalis K, Deng W and Pleasure D.2015 
Chronological protein synthesis in regenerating rat liver. ElectrophoresisHe J, Hao S, Zhang H, Guo F, Huang L, Xiao X, He D.2015HTML
Conditional ablation of astroglial CCL2 suppresses CNS accumulation of m1 macrophages and preserves axons in mice with MOG peptide EAE. J Neurosci; 34, 8175-8185. [PMID: 24920622]Moreno M, Bannerman P, Ma J, Guo F, Miers L, Soulika A, Pleasure D2014HTML
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Deletion of astroglial CXCL10 delays clinical onset but does not affect progressive axon loss in a murine autoimmune multiple sclerosis model. J Neuroinflam 11, 105. [PMID: 24924222]Ko EM, Ma J, Guo F, Miers L, Lee E, Bannerman P, Burns T, Ko D, Sohn J, Soulika A, Pleasure D2014HTML
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Stress and glucocorticoids promote oligodendrogenesis in the adult hippocampus. Mol Psychiatry doi: 10.1038/mp.2013.190. [PMID: 24514565]Chetty S, Friedman AR, Taravosh-Lahn K, Kirby ED, Mirescu C, Guo F, Krupik D, Nicholas A, Geraghty AC, Krishnamurthy A, Tsai MK, Covarrubias D, Wong AT, Francis DD, Sapolsky RM, Palmer TD, Pleasure D, Kaufer D2014HTML
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Origins and significance of astrogliosis in the multiple sclerosis model, MOG peptide EAE. J Neurol Sci. S0022-510X(12)00638-7. [PMID: 23294494]Moreno M, Guo F, Ko EM, Bannerman P, Soulika A, Pleasure D2013HTML
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Adenomatous Polyposis Coli Regulates Oligodendroglial Development. J Neurosci 33: 3113-30. [PMID: 23407966]Lang J, Maeda Y, Bannerman P, Xu J, Horiuchi M, Pleasure D, and Guo F2013HTML
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Olig2/Plp progenitor cells give rise to Bergmann glia in the cerebellum. Cell Death and Disease 14;4:e546 [PMID: 23492777]Chung SH, Guo F, Jiang P, Pleasure E, Deng W2013HTML
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Disruption of NMDA receptors in oligodendroglial lineage cells does not alter their susceptibility to EAE or their normal development. J Neurosci. 32:639-45. [PMID: 22238099]Guo F, Maeda Y, Ko EM, Delgado M, Horiuchi M, Soulika A, Miers L, Burns T, Itoh T, Shen H, Lee E, Sohn J, Pleasure D2012HTML
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PEDF is a novel oligodendrogenic morphogen acting on the adult SVZ and corpus callosum. J Neurosci. 32:12152-64. [PMID: 22933798]Sohn J, Selvaraj V, Wakayama K, Orosco L, Lee E, Crawford SE, Guo F, Lang J, Horiuchi M, Zarbalis K, Itoh T, Deng W, Pleasure D2012HTML
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Macroglial plasticity and genetic origin of reactive astrocytes in experimental autoimmune encephalomyelitis. J Neurosci 31:11914-28. [PMID: 21849552]Guo F, Maeda Y, Ma J, Delgado M, Miers L, Ko EM, Bannerman P, Xu J, Wang Y, Zhou C, Takebayashi H, Pleasure D2011HTML
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Triple labeling with three thymidine analogs reveals a well-orchestrated regulation of hepatocyte proliferation during liver regeneration. Hepatol Res. 41(12):1230-9. [PMID:21917088]Wu Y, Guo F, Liu J, Xiao X, Huang L, He D2011HTML
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Pyramidal neurons are generated from oligodendroglial progenitor cells in adult piriform cortex. J Neurosci 30:12036-12049. [PMID: 20826667]Guo F, Maeda Y, Ma J, Xu J, Horiuchi M, Miers L, Vaccarino F, Pleasure D2010HTML
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Early postnatal proteolipid promoter-expressing progenitors produce multilineage cells in vivo. J Neurosci 29:7256-7270. [PMID: 19494148]Guo F, Ma J, McCauley E, Bannerman P, Pleasure D2009HTML
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A high-temporal resolution technology for dynamic proteomic analysis based on 35S labeling. PLoS One. 3(8):e2991. [PMID:18714357]Zhang Z, Chen J, Guo F, He L, Wu Y, Zeng C, Xiao X, He D.2008HTML
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Proteomic analysis of the transition from quiescent to proliferating stages in rat liver hepatectomy model. Proteomics 6:3075-3086. [PMID: 16619303]Guo F, Nian H, Zhang H, Huang L, Tang Y, Xiao X, He D2006HTML
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Discovery of laryngeal carcinoma by serum proteomic pattern analysis. Sci China C Life Sci. 47(3):219-23.[PMID:15524278]Xiao X, Zhao X, Liu J, Guo F, Liu D, He D.2004HTML
Development of proteomic patterns for detecting lung cancer.Dis Markers. 19(1):33-9.[PMID: 14757945]Xiao X, Liu D, Tang Y, Guo F, Xia L, Liu J, He D2003HTML
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