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Zarbalis, Konstantinos

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Konstantinos Zarbalis
Title:
Assistant Investigator, Shriners Hospitals for Children
Assistant Professor, Department of Pathology & Laboratory Medicine, UCD SOM
Office Address: 2425 Stockton Blvd, Room 671
Sacramento, CA 95817
Office Phone:
(916) 453-2189
E-Mail Address: kzarbalis (at) ucdavis.edu
Education: Postdoctoral Training, Developmental Neurobiology, UCSF
PhD, Molecular Biology and Genetics, Technical University Munich, Germany
MS, Biology, Technical University Munich, Germany
Research Papers: Click Here for Research Paper Links

Research Interests:

The analysis of genetic and molecular mechanisms regulating neural and craniofacial development.

Current Research:

Among the most important tools in the analysis of developmental processes like growth, patterning, and differentiation has been the study of mutants, in which aspects of development are adversely affected. A powerful approach to obtain developmental mutants is forward genetic screens. We carried out such a screen in the mouse aimed at the identification of mutants displaying forebrain defects. Several mutant lines with defects during forebrain development were recovered and the mutated genes identified. Neuronal defects in the lines obtained affect overall cortical morphology, neuronal migration, cortical lamination, and thalamocortical connectivity. Other lines show craniofacial defects of great interest affecting orofacial and skull morphology. Current projects involve the molecular, cellular, and morphological analysis of these mutants.


Noteworthy Publications:

* equal contribution
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Maternal exposure to carbamazepine at environmental concentrations can cross intestinal and placental barriers. Biochem Biophys Res Commun. 474(2):291-5 (2016). doi: 10.1016/j.bbrc.2016.04.088. Kaushik G., Huber D. P., Aho K., Finney B., Bearden S., Zarbalis K. S. Thomas M. A.: 2016
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Prenatal neurogenesis in autism spectrum disorders. Front. Chem. 4 (2016). doi: 10.3389/fchem.2016.00012 Kaushik G., Zarbalis K. S.: 2016
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The subventricular zone continues to generate corpus callosum and rostral migratory stream astroglia in normal adult mice. J. Neurosci. 35(9) (2015) 3756-3763. doi: 10.1523/JNEUROSCI.3454-14.2015. Sohn J., Orosco L. A., Guo F., Chung S. H., Bannerman P., Mills Ko E., Zarbalis K. S., Deng W., Pleasure D. 2015
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Loss of Wdfy3 in mice alters cerebral cortical neurogenesis reflecting aspects of the autism pathology. Nat. Commun. 5:4692. doi: 10.1038/ncomms5692. (2014). Orosco L. A., Ross A. P., Cates S. L, Scott S. E., Wu D., Sohn J., Pleasure D., Pleasure S. J., Adamopoulos I. E., Zarbalis K. S. 2014
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Il-17A induces bone destruction and epidermal hyperplasia associated with psoriatic arthritis. Ann Rheum Dis. doi: 10.1136/annrheumdis-2013-204782 (2014). Adamopoulos I. E., Suzuki E., Chao C., Gorman D., Shin H., Laface D., Maverakis E., Zarbalis K. S., Geissler R., Gershwin M. E., Bowman E. P. 2014
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Neural crest-derived mesenchymal cells require Wnt signaling for their development and drive invagination of the telencephalic midline. PLoS One 9(2): e86025 (2014). Youngshik C., Zarbalis K. S., Pleasure S. J. 2014
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The emerging roles of ribosome biogenesis in craniofacial development. Front. Physiol. 5:26. (2014). Ross A. P., Zarbalis K. S. 2014
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A mutation in mouse Pak1ip1 causes orofacial clefting while human PAK1IP1 maps to 6p24 translocation breaking points associated with orofacial clefting. PLoS One 8(7): e69333 (2013). Ross A., Mansilla M. A., Youngshik C., Helminski S., Maute R. L., May S. R., Hozyasz K. K., Wójcicki P., Mostowska A., Davidson B., Adamopoulos I. E., Pleasure S. J., Murray J.C., Zarbalis K. S. 2013
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PEDF is a novel oligodendrogenic morphogen acting on the adult SVZ and corpus callosum. J. Neurosci. (2012), in press. Sohn J., Selvaraj V., Wakayama K., Orosco L. A., Lee E., Guo F., Horiuchi M., Zarbalis K., Itoh T., Deng W., Pleasure D. 2012


Meningeal defects alter the tangential migration of cortical interneurons in Foxc1hith/hith mice. Neural Development 7:2 (2012). Zarbalis K., Choe, Y., Siegenthaler J. A., Orosco L. A., Pleasure S. J. 2012
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A mutation in the pericentrin gene causes abnormal interneuron migration to the olfactory bulb in mice. Dev. Biol. 340 (2010) 41-53. Endoh-Yamagami S., Karkar K. M., May S. R., Cobos I., Thwin M. T., Long J. E., Ashique A. A., Zarbalis K., John L.R. Rubenstein, Andrew S. Peterson. 2010
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Extracellular Engrailed participates in the topographic guidance of retinal axons in vivo. Neuron 64 (2009) 355-366. Wizenmann A., Brunet I., Lam J., Sonnier L., Beurdeley M., Zarbalis K., Weisenhorn-Vogt D., Weinl C., Dwivedy A., Joliot A., Holt C., Wurst W., Prochiantz A. 2009
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Retinoic acid from the meninges regulates cortical neuron generation. Cell 139 (2009) 597-609. Siegenthaler J. A., Ashique A. M.*, Zarbalis K.*, Patterson K. P., Hecht J. H., Kane M. A., Folias A. E., Choe Y., May S. R., Kume T., Napoli J. L., Peterson A. S., Pleasure S. J. 2009
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Cortical dysplasia and skull defects in mice with a novel Foxc1 allele reveal the role of meningeal differentiation in regulating cortical development. PNAS 104 (2007) 14002–14007. Zarbalis K.*, Siegenthaler J. A.*, Choe Y., May S. R., Peterson A. S., Pleasure S. J. 2007
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EphA-Ephrin-A-mediated beta cell communication regulates insulin secretion from pancreatic islets. Cell 129 (2007) 359-370. Konstantinova I., Nikolova G., Ohara-Imaizumi M., Meda P., Kucera T., Zarbalis K., Wurst W., Nagamatsu S., Lammert E. 2007
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The tumour-suppressor Scribble dictates cell polarity during directed epithelial migration: regulation of Rho GTPase recruitment to the leading edge. Oncogene 26 (2007) 2272-2282 [with correction in 26 (2007) 5692]. Dow L. E., Kauffman J. S., Caddy J., Zarbalis K., Peterson A. S., Jane S. M., Russell S. M., Humbert P. O. 2007
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Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli. Dev Biol. 287 (2005) 378-89. May S. R., Ashique A. M., Karlenc M., Wang B., Shen Y., Zarbalis K., Reiter J., Ericson J., Peterson A. S. 2005
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A focused and efficient genetic screening strategy in the mouse: Identification of mutations that disrupt cortical development. PLoS Biology 2 (2004) 1177-1187. Zarbalis, K.*, May, R. S.*, Shen, Y., Ekker, M., Rubenstein, J. L. R., Peterson, A. 2004
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Multiple roles of ephrins during the formation of thalamocortical projections: Maps and more. J. Neurobiol. 59 (2004) 82-94. Bolz, J., Mühlfriedel, S., Güllmar, A., Peuckert, C., Zarbalis, K., Wurst, W., Masaaki, T., Levitt, P. 2004
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Miswiring of limbic thalamocortical projections in the absence of ephrin-A5. J. Neurosci. 22 (2002) 9352-9357. Uziel D., Mühlfriedel S., Zarbalis K., Wurst W., Levitt P., Bolz J. 2002
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A role for the EphA family in the topographic targeting of vomeronasal axons. Development 128 (2001) 895-906. Knöll B.*, Zarbalis K.*, Wurst W., Drescher U. 2001
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Expression domains of murine ephrin-A5 in the pituitary and hypothalamus. Mech. Dev. 93 (2000) 165-168. Zarbalis K. and Wurst W. 2000
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