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Martinez-Cerdeno, Veronica
Title:
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Assistant Investigator, Shriners Hospitals for Children
Assistant Professor, Department of Pathology & Laboratory Medicine, University of California, Davis
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Office Address:
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2425 Stockton Blvd, Room 671
Sacramento, CA 95817
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Office Phone:
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(916) 453-2163
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E-Mail Address:
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vmartinezcerdeno (at) ucdavis.edu
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Education:
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Complutense University, Madrid, Spain B.S. 1993-98 Biology
Autonóma University of Madrid, Spain Ph.D. 1998-02 Neuroscience
Columbia University, NY Postdoctoral training 2002-04 Brain Development
University of California, San Francisco Postdoctoral training 2004-07 Brain Development
University of California, Davis, M.I.N.D. Institute, Postdoctoral training 2007-08 Autism
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Research Papers:
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Click Here for Research Paper Links
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Research Interests:
Stem and progenitor cell properties and behavior in the normal and pathogenic developing cerebral cortex. Stem and progenitor cells as treatment for traumatic and neurodegenerative diseases. Stem and progenitor cell role in the evolution of the cerebral cortex
Current Research:
Stem cells have the capacity to self-renew themselves, and to generate multiple daughter cell types. Progenitor cells have restricted capacity for self-renewal and generate a limited number of daughter cell types. In the developing cerebral cortex we find both stem cells called radial glial cells (RGCs) and progenitor cells called intermediate progenitor cells (IPCs). Defects in the normal pattern of RGC and IPC proliferation and defects in daughter cell migration underlie the neuropathology associated with various neurological and psychiatric conditions. We investigate stem and progenitor cells behavior in normal and pathogenic developing cerebral cortex. Our current focus is on stem cell behavior and properties in diseases with an early developmental onset, such as Autism. In a parallel line of research we are investigating stem cell and progenitor cell behavior and function after transplantation into specific brain areas, and into injured spinal cord.
Noteworthy Publications:
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c- and N-myc Regulate Neural Precursor Cell Fate, Cell Cycle, and Metabolism to Direct Cerebellar Development. Cerebellum. 2010
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Wey A, Martinez-Cerdeño V, Pleasure D, Knoepfler PS.
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2010
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Premutation CGG-repeat expansion of the Fmr1 gene impairs mouse neocortical development. Human Molecular Genetics. in press.
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Cunningham, C. L., Martinez-Cerdeño V., Navarro E. , Prakash A., Willemsen R., Hagerman P. J., Pessah I. N., Berman R. F., Noctor S. C.
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2010
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Embryonic MGE precursors grafted into adult rat striatum integrate and ameliorate Parkinson’s symptoms. Cell Stem Cell
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Martínez-Cerdeño V., Noctor S.C., Espinosa A., Ariza J, Parker P., Orasji S., Daadi M., Bankiewicz K., Alvarez-Buylla A., Kriegstein A.
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2010
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Distinct behaviors of neuronal stem and progenitor cells underlie cortical neurogenesis. Journal of Comparative Neurology. 508:28-44
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Noctor SC., Martínez-Cerdeño V., Kriegstein AR.
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2008
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Embryonic and Postnatal Development of the Layer I-Directed ("Matrix") Thalamocortical System in the Rat. Cereb Cortex 18(2):344-63
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Galazo MJ., Martínez-Cerdeño V., Porrero C., Clascá F.
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2008
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Progenitors from the postnatal forebrain subventricular zone differenciate into cerebellar-like interneurons and cerebellar-specific astrocytes upon transplantation. Molecular and cellular Neuroscience. Mol Cell Neurosci. 39(3):324-34
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Milosevic A., Noctor S.C., Martínez-Cerdeño V., Kriegstein AR., Goldman JE.
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2008
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Neural Stem and Progenitor cells in cortical development. Novartis Found Symposium. 288:59-73
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Noctor SC., Martínez-Cerdeño V., Kriegstein AR.
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2007
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he contribution of intermediate progenitor cells to cortical histogenesis. Archives in Neurology. 64(5):639-42
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Noctor SC., Martínez-Cerdeño V., Kriegstein AR.
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2007
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Estradiol stimulates progenitor cell division in the Ventricular and Subventricular Zones of the Embryonic Neocortex. Eur J Neurosci Vol. 24: 3475-88
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Martínez-Cerdeño V., Noctor SC., Kriegstein AR.
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2006
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Patterns of neuronal stem and progenitor cell division may underlie evolutionary cortical expansion. Nature Rev Neurosci. 7(11): 883-90
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Kriegstein A., Noctor S., Martínez-Cerdeño V.
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2006
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The role of abventricular mitoses in the evolutionary expansion of the cerebral cortex. Cereb Cortex. 16 Suppl 1:i152-61
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Martínez-Cerdeño V., Noctor SC., Kriegstein AR.
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2006
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Extracellular matrix molecules and synaptic plasticity: Immunomapping of intracellular and secreted Reelin in the adult rat brain. Eur J Neurosci. 23:401-22
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Ramos-Moreno T., Galazo MJ., Porrero C., Martínez-Cerdeño V., Clasca F.
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2006
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The role of neurogenic astroglial cells in the developing and adult central nervous system. In: Kettenmann, H., and Ransom, B.R., eds. Neuroglia, Oxford: 101-111
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Noctor SC., Ivic L., Martínez-Cerdeño V., Kriegstein AR. (2005)
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2005
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Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phases. Nature Neurosci. 7:136-44
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Noctor SC., Martínez-Cerdeño V., Ivic L, Kriegstein AR. (2004)
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2004
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Reelin-immunoreactive neurons, axons, and neuropil in the adult ferret brain: Evidence for axonal secretion of reelin in long axonal pathways. J Comp Neurol. 463:92-116
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Martínez-Cerdeño V., Galazo MJ., Clasca F.
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2003
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Reelin immunoreactivity in the adult primate brain: Intracellular localization in projecting and local circuit neurons of the cerebral cortex, hippocampus, and subcortical regions. Cereb Cortex. 12:1298-1311
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Martínez-Cerdeño V., Galazo MJ., Cavada C., Clasca F.
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2002
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Reelin immunoreactivity in the adult neocortex: A comparative study in rodents, carnivores, and non-human primates. Br Res Bull. 57:485-488
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Martínez-Cerdeño V., Clasca F.
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2002
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IPRM
2425 Stockton Blvd.
Sacramento, CA 95817
(916) 453-2290
webmaster (at) iprmd.org
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