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Personal tools
David Pleasure, MD
Title:
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Distinguished Professor, UC Davis
Honorary Member, American Neurological Association
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Office Address:
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2425 Stockton Blvd, Room 602A
Sacramento, CA 95817
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Office Phone:
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(916) 453-2331
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E-Mail Address:
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david.pleasure (at) ucdmc.ucdavis.edu
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Education:
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BA Yale College
MD College of Physicians and Surgeons,
Columbia University
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Research Papers:
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Click Here for Research Paper Links
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Research Interests:
Development and regeneration of the nervous system; pathogenesis of demyelinative diseases.
Current Research:
Mechanisms of CNS injury and repair in autoimmune demyelinative diseases
Noteworthy Publications:
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AUTHOR(s)
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PEDF is a novel oligodendrogenic morphogen acting on the adult SVZ and corpus callosum. J Neurosci 32:12152-12164, 2012 (PMID: 22933798).
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Sohn, Selvaraj, Wakayama, Orosco, Lee, Crawford, Guo, Lang, Horiuchi, Zarbalis, Itoh, Deng, Pleasure.
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2012
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Adenomatous polyposis coli regulates oligodendroglial development. J Neurosci 33:3113-3130, 2012 (PMID: 23407966).
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Lang, Maeda, Bannerman, Xu, Horiuchi, Pleasure, Guo.
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2012
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Disruption of NMDA receptors in oligodendroglial lineage cells does not alter their susceptibility to EAE or their normal development. J Neurosci 32:639-645, 2012 (PMID: 22238099).
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Guo, Maeda, Mills Ko, Delgado, Horiuchi, Soulika, Miers, Burns, Itoh, Shen, Lee, Sohn, and Pleasure
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2012
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IFN-gamma signaling in the central nervous system controls the course of experimental autoimmune encephalomyelitis independently of the localization and composition of inflammatory foci. J Neuroinflam 9:7, 2012 (PMID: 22248039).
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Lee, Chanamara, Pleasure, and Soulika,
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2012
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Macroglial Plasticity and the Origins of Reactive Astroglia in Experimental Autoimmune Encephalomyelitis
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Fuzheng Guo, Yoshiko Maeda, Joyce Ma, Monica Delgado, Jiho Sohn, Laird Miers, Emily Mills Ko, Peter Bannerman, Jie Xu, Yazhou Wang, Chengji Zhou, Hirohide Takebayashi, and David Pleasure
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2011
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Zfp488 promotes oligodendrocyte differentiation of neural progenitor cells in adult mice after demyelination
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Mangala M. Soundarapandian, Vimal Selvaraj, U-Ging Lo, Mari S. Golub, Daniel H. Feldman, David E. Pleasure & Wenbin Deng
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2011
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Pyramidal neurons are generated from oligodendroglial progenitor cells in adult piriform cortex.
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Guo F, Maeda Y, Ma J, Xu J, Horiuchi M, Miers L, Vaccarino F, Pleasure D. J Neurosci. 2010 Sep 8;30(36):12036-49.PMID: 20826667
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2010
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Differing in vitro survival dependency of mouse and rat NG2+ oligodendroglial progenitor cells.
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Horiuchi M, Lindsten T, Pleasure D, Itoh T. J Neurosci Res. 2010 Apr;88(5):957-70.PMID: 19908280
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2010
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Maintenance of the relative proportion of oligodendrocytes to axons even in the absence of BAX and BAK.
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Kawai K, Itoh T, Itoh A, Horiuchi M, Wakayama K, Bannerman P, Garbern JY, Pleasure D, Lindsten T. Eur J Neurosci. 2009 Dec 3;30(11):2030-41. Epub 2009 Nov 25.PMID: 20128842
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2009
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Initiation and progression of axonopathy in experimental autoimmune encephalomyelitis.
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Soulika AM, Lee E, McCauley E, Miers L, Bannerman P, Pleasure D. J Neurosci. 2009 Nov 25;29(47):14965-79.PMID: 19940192
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2009
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Lrp6-mediated canonical Wnt signaling is required for lip formation and fusion.
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Song L, Li Y, Wang K, Wang YZ, Molotkov A, Gao L, Zhao T, Yamagami T, Wang Y, Gan Q, Pleasure DE, Zhou CJ. Development. 2009 Sep;136(18):3161-71.
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2009
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PARP-1 deficiency increases the severity of disease in a mouse model of multiple sclerosis.
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Selvaraj V, Soundarapandian MM, Chechneva O, Williams AJ, Sidorov MK, Soulika AM, Pleasure DE, Deng W. J Biol Chem. 2009 Jul 23. [Epub ahead of print]
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2009
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Early postnatal proteolipid promoter-expressing progenitors produce multilineage cells in vivo.
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Guo F, Ma J, McCauley E, Bannerman P, Pleasure D. J Neurosci. 2009 Jun 3;29(22):7256-70
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2009
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Impaired regenerative response of primary sensory neurons in ZPK/DLK gene-trap mice.
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Itoh A, Horiuchi M, Bannerman P, Pleasure D, Itoh T. Biochem Biophys Res Commun. 2009 May 29;383(2):258-62. Epub 2009 Apr 7.
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2009
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Ocular coloboma and dorsoventral neuroretinal patterning defects in Lrp6 mutant eyes.
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Zhou CJ, Molotkov A, Song L, Li Y, Pleasure DE, Pleasure SJ, Wang YZ. Dev Dyn. 2008 Dec;237(12):3681-9
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2008
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Activation of the Wnt/beta-catenin signaling reporter in developing mouse olfactory nerve layer marks a specialized subgroup of olfactory ensheathing cells.
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Wang YZ, Molotkov A, Song L, Li Y, Pleasure DE, Zhou CJ. Dev Dyn. 2008 Nov;237(11):3157-68.
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2008
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Characterization of acid-sensing ion channel expression in oligodendrocyte-lineage cells. Glia Early View, PUBLISHED ONLINE May 1, 2008, in advance of print.
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Feldman DH, Horiuchi M, Keachie K, McCauley E, Bannerman P, Itoh A, Itoh T, Pleasure D
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2008
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Bone morphogenetic proteins 4, 6, and 7 are upregulated in mouse spinal cord during experimental autoimmune encephalomyelitis. J Neurosci Res 86:125-135, 2008.
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Ara, See, Mamntov, Citrin, Bannerman, Pleasure, and Grinspan
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2008
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MEK-ERK signaling is involved in interferon-γ-induced death of oligodendroglial progenitor cells. J Biol Chem 281:20095-20106.
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Horiuchi, Itoh, Pleasure, Itoh
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2007
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Astrogliosis in EAE spinal cord: derivation from radial glia, and relationships to oligodendroglia. Glia 5:57-64.
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Bannerman, Hahn, Soulika, Gallo, Pleasure
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2006
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IPRM
2425 Stockton Blvd.
Sacramento, CA 95817
(916) 453-2290
webmaster (at) iprmd.org
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