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Personal tools
Title:
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Professor
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Office Address:
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2425 Stockton Blvd, Room 602B
Sacramento, CA 95817
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Office Phone:
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(916) 453-2268
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E-Mail Address:
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cjzhou (at) ucdavis.edu
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Education:
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PhD, Waseda University (Tokyo, Japan)
Postdoc, University of California at San Francisco
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Research Papers:
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Click Here for Research Paper Links
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Research Interests:
Molecular mechanism of pattern formation during embryonic neural development and pattern maintenance for postembryonic neural stem cell renewal and tissue regeneration
Current Research:
Tissue/organ morphogenesis is regulated by several inductive factors such as Wnts. Incorrect activity and timing of Wnt signaling during development frequently result in embryonic death or severe birth defects including neural tube defects (NTD), brain developmental disorders, and craniofacial abnormalities—they are all common birth defects in humans. We are investigating molecular and cellular mechanisms of these developmental disorders and prevention strategies using Wnt signaling mutants as the research model. We are also investigating the role of Wnt signaling in neural stem cell renewal and regeneration processes to enhance their therapeutic potential for patients with injured nerve tissues.
For more information please visit the Zhou lab homepage at: Zhou Lab Homepage
Noteworthy Publications:
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AUTHOR(s)
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Transient activation of Wnt/β-catenin signaling reporter in fibrotic scar formation after compression spinal cord injury in adult mice. Biochemical and Biophysical Research Communications In Press. https://doi.org/10.1016/j.bbrc.2018.02.004
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Yamagami T, Pleasure DE, Lam KS, Zhou CJ.
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2018
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Wnt signaling in kidney development and disease. Progress in Molecular Biology and Translational Science 153:181-207. DOI: 10.1016/bs.pmbts.2017.11.019
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Wang Y, Zhou CJ, Liu Y.
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2018
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Celecoxib targets breast cancer stem cells by inhibiting the synthesis of prostaglandin E2 and down-regulating the Wnt pathway activity. Oncotarget 8:115254-115269. doi: 10.18632/oncotarget.23250
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Huang C, Chen Y, Liu H, Jing Yang, Song X, Zhao J, Na He N, Zhou CJ, Wang Y, Huang C, Dong Q.
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2017
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Focused screening of mitochondrial metabolism reveals a crucial role for a tumor suppressor Hbp1 in ovarian reserve. Cell Death and Differentiation doi: 10.1038/cdd.2016.47. [Epub ahead of print]
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Dong Z, Huang M, Liu Z, Xie P, Dong Y, Wu X, Qu Z, Shen B, Huang X, Zhang T, Li J, Liu J, Yanase T, Zhou C, Xu Y.
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2016
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Lrp6 modulates Ret signaling in renal development and cystic dysplasia. Journal of the American Society of Nephrology 27:417-427. DOI: 10.1681/ASN.2014100998
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Wang Y, Stokes A, Duan Z, Hui J, Xu Y, Chen YP, Chen HW, Lam K, Zhou CJ.
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2015
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Beta-catenin regulates Pax3 and Cdx2 for caudal neural tube closure and elongation. Development 141:148-157. DOI: 10.1242/dev.101550
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Zhao T*, Gan Q*, Stokes A, Lassiter RN, Wang YP, Chan J, Han J, Pleasure DE, Epstein JA, Zhou CJ.
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2014
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Pax6 mediates ß-catenin signaling for self-renewal and neurogenesis by neocortical radial glial stem cells. Stem Cells 32:45-58. DOI: 10.1002/stem.1561
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Gan Q*, Lee A*, Suzuki R*, Yamagami T, Stokes A, Nguyen B, Pleasure D, Wang J, Chen HW, Zhou CJ.
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2014
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Signaling mechanisms controlling cranial placode neurogenesis and delamination. Developmental Biology 389:39-49. DOI: 10.1016/j.ydbio.2013.11.025
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Lassiter RN, Stark MR, Zhao T, Zhou CJ.
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2014
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Macroglial plasticity and the origins of reactive astroglia in experimental autoimmune encephalomyelitis. Journal of Neuroscience 31:11914-11928.
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Guo F, Maeda Y, Ma J, Delgado M, Sohn J, Miers L, Ko EM, Bannerman P, Xu J, Wang Y, Zhou CJ, Takebayashi H, Pleasure D*.
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2011
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Concise Review: Quiescent and active states of endogenous adult neural stem cells: identification and characterization. Stem Cells 29:907-912.
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Wang YZ*, Plane JM, Jiang P, Zhou CJ*, Deng W*.
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2011
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Epithelial Wnt/ß-catenin signaling regulates palatal shelf fusion through regulation of Tgfß3 expression. Developmental Biology 350:511-519.
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He F, Xiong W, Wang Y, Li L, Liu C, Yamagami T, Taketo MM, Zhou CJ, Chen Y*
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2011
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Canonical Wnt signaling promotes proliferation and neurogenesis of peripheral olfactory stem cells/progenitors during postnatal development and adult regeneration. Journal of Cell Science Journal of Cell Science 124:1553-1563. (Journal Cover)
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Wang YZ, Yamagami T, Gan Q, Wang Y, Zhao T, Hamad S, Lott P, Schnittke N, Schwob JE, Zhou CJ*
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2011
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The canonical Wnt/beta-catenin signaling pathway regulates Fgf signaling for early facial development. Developmental Biology 349:250-260.
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Wang Y, Song L, Zhou CJ*
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2011
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Generation of the Lrp6 conditional mutant mouse line for modeling and dissecting multiple birth defects/congenital diseases. Developmental Dynamics. 239:318-326
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Zhou CJ*, Wang YZ, Yamagami T, Zhao T, Song L, Wang K
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2010
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Cardiac neural crest and outflow tract defects in Lrp6 mutant mice. Developmental Dynamics 239:200-210.
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Song L, Li Y, Wang K, Zhou CJ*
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2010
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Lrp6-mediated canonical Wnt signaling is required for lip formation and fusion. Development 136:3161-3171.
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Song L, Li Y, Wang K, Wang YZ, Molotkov A, Gao L, Zhao T, Yamagami T, Wang Y, Gan Q, Pleasure DE, Zhou CJ*
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2009
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Canonical Wnt signaling activity during synovial joint development. J Mol Histol 40:311-316. 2009
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Yamagami T, Molotkov A, Zhou CJ.
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2009
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Activation of the Wnt/beta-catenin signaling reporter in developing mouse olfactory nerve layer marks a specialized subgroup of olfactory ensheathing cells. Developmental Dynamics 237:3157-3168.
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Wang YZ, Molotkov A, Song L, Li Y, Pleasure DE, Zhou CJ*
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2008
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Ocular coloboma and dorsoventral neuroretinal patterning defects in Lrp6 mutant eyes. Developmental Dynamics 237:3681-3689.
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Zhou CJ*, Molotkov A, Song L, Li Y, Pleasure DE, Pleasure SJ, Wang YZ.
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2008
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Neuronal production and precursor proliferation defects in the neocortex of mice with loss of function in the canonical Wnt signaling pathway. Neuroscience 142: 1119-1131.
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Zhou CJ, Borello U, Rubenstein JLR, Pleasure SJ
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2006
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Severe defects of dorsal thalamus in low-density lipoprotein receptor-related protein-6 mutants. J Neurosci 24:7632-7639. (Editorial Featured Article)
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Zhou CJ, Pinson KI, Pleasure SJ
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2004
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Wnt signaling mutants have decreased dentate granule cell production and radial glial scaffolding abnormalities. J Neurosci 24:121-126.
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Zhou CJ, Zhao C, Pleasure SJ
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2004
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PACAP and its receptors exert pleiotropic effects in the nervous system by activating multiple signaling pathways. Current Protein & Peptide Science 3, 423-439. (Invited Review; *Corresponding Author)
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Zhou CJ*, Shioda S, Yada T, Inagaki N, Pleasure S, Kikuyama S
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2002
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ATP-binding Cassette Transporter ABCA2 (ABC2) Expression in the developing spinal cord and PNS during myelination. J Comp Neurol 451:334-345. (*Corresponding Author)
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Zhou CJ*, Inagaki N, Pleasure S, Zhao LX, Kikuyama S, Shioda S
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2002
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PACAP activates PKA, PKC and Ca2+ signaling cascades in rat neuroepithelial cells. Peptides 22:1111-1117.
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Zhou CJ, Yada T, Kohno D, Kikuyama S, Suzuki R, Mizushima H, Shioda S
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2001
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ATP-binding cassette transporter ABC2/ABCA2 in the rat brain: a novel mammalian lysosome-associated membrane protein and a specific marker for oligodendrocytes but not for myelin sheaths. J Neurosci 21:849-857.
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Zhou CJ, Zhao LX, Inagaki N, Guan J, Nakajo S, Hirabayashi T, Kikuyama S, Shioda S
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2001
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IPRM
2425 Stockton Blvd.
Sacramento, CA 95817
Tele: (916) 453-2227
Fax: (916) 453-2288
webmaster (at) iprmd.org
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