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Deng, Wenbin

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Wenbin Deng
Title:
Professor
Office Address: 2425 Stockton Blvd, Room 631A
Sacramento, CA 95817
Office Phone:
(916) 453-2287
E-Mail Address: wbdeng (at) ucdavis.edu
Education: Postdoctoral Fellowship, Harvard Medical School
Ph.D., Rutgers University
Research Papers: Click Here for Research Paper Links

Research Interests:

Nervous system development and disease; Receptor biology and signal transduction; Basic and translational research in neural injury and repair.

Current Research:

Our lab is interested in studying molecular mechanisms controlling nervous system development and disease. A central theme of our research program has been on pursuing links between genes, gene products, and physiological/pathological processes. Specifically, we use combined biochemical/molecular/cellular and integrative approaches applied to both in vitro and in vivo models to study the role of neurotransmitter receptors and their signaling pathways in the regulation of neural cell proliferation, survival, and differentiation in a cell-specific manner. This research has helped to define at the molecular level the plasticity of brain cells and their potential for enhancing repair of damage caused by brain injury and disease.

Glutamate is a major excitatory neurotransmitter in the brain, but can also cause excitotoxic injury to the nervous system under many pathological circumstances. Previous research has been focused largely, if not exclusively, on neuronal excitotoxicity. However, emerging evidence indicates that the precursors of oligodendrocytes, the myelin-forming glial cells in the central nervous system, share with neurons a high vulnerability to glutamate excitotoxicity that may underlie many nervous system disorders. These precursor cells emerge early in development and remain persistent throughout the adult life. We have been determining the role of glutamate receptors expressed on these cells in nervous system development and injury.

This work has important implications in nervous system diseases from cerebral palsy to multiple sclerosis, in which oligodendroglial injury plays an important role. This research has also opened up exciting new directions in uncovering novel mechanisms of glial excitotoxicity in other neurological and psychiatric disorders.


Noteworthy Publications:

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AUTHOR(s)
YEAR
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Human iPSC-derived immature astroglia promote oligodendrogenesis by increasing TIMP-1 secretion. Cell Reports, 15 (6): 1303-1315. doi: 10.1016/j.celrep.2016.04.011. PMID: 27134175. Jiang P, Chen C, Liu X, Pleasure DE, Liu Y, Deng W. (2016) 2016
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The hGFAP-driven conditional TSPO knockout is protective in a mouse model of multiple sclerosis. Sci. Reports, 2016 Mar 1;6:22556. doi: 10.1038/srep22556. PMID: 26925573. http://www.nature.com/articles/srep22556. Daugherty DJ, Chechneva OV, Mayrhofer F, Deng W. (2016) 2016
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The crystal structure of monovalent streptavidin. Sci. Reports, 2016 Dec 1; 6:35915. DOI: 10.1038/srep35915. http://www.nature.com/articles/srep35915. *Co-correspondence authors. Zhang M, Biswas S, Deng W*, Yu H*. (2016) 2016
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Same-single-cell analysis of pacemaker-specific markers in human induced pluripotent stem cell-derived cardiomyocyte subtypes classified by electrophysiology. Stem Cells. 2016 Jul 19. doi: 10.1002/stem.2466. PMID: 27434649. Yechikov S, Copaciu R, Gluck JM, Deng W, Chiamvimonvat N, Chan JW, Lieu DK. (2016) 2016
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Mitochondrial translocator protein (TSPO), astrocytes and neuroinflammation. Neural Regen Res 11(7):1056-1057. PMID: 27630677 Chechneva OV, Deng W. (2016) 2016
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Regenerating white matter using human iPSC-derived immature astroglia. Neurogenesis (Austin). 2016 Sep 8; 3(1):e1224453. doi: 10.1080/23262133.2016.1224453. eCollection 2016. PMID: 27652287 Jiang P, Deng W. (2016) 2016
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Rationale and methodology of reprogramming for generation of induced pluripotent stem cells and induced neural progenitor cells. Int. J. Mol. Sci. 17 (4), 594; doi:10.3390/ijms17040594. *Co-correspondence authors. Tian Z, Guo F, Biswas S*, Deng W*. (2016) 2016
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Does Notch play a tumor suppressor role across diverse carcinomas? Cancer Med., in press. *Co-correspondence authors. Zhang M, Biswas S, Qin X, Gong W, Deng W*, Yu H*. (2016) 2016
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The vulnerability of thalamocortical circuitry to hypoxic-ischemic injury in a mouse model of periventricular leukomalacia. BMC Neurosci, 17 (2), DOI 10.1186/s12868-015-0237-4. Liu X, Shen Y, Pleasure DE, Deng W. (2016) 2016
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Argonaute and argonaute-bound small RNAs in stem cells. Int. J. Mol. Sci.. 17 (2): 208. doi: 10.3390/ijms17020208 Zhai L, Wang L, Teng F, Zhou L, Zhang W, Xiao J, Liu Y, Deng W. (2016) 2016
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Reverse engineering human neurodegenerative disease using pluripotent stem cell technology. Brain Res 1638: 30-41. doi: 10.1016/j.brainres.2015.09.023. Liu Y, Deng W. (2015) 2015
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Stem and progenitor cell-derived astroglia therapies for neurological diseases. Trends Mol Med, 21 (11): 715-729. *Co-correspondence authors. Chen C, Chan A, Wen H, Chung SH, Deng W*, Jiang P*. (2015) 2015
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Human iPSC NEUROG2 dual reporter knockin lines generated by the CRISPR/Cas9 system. Stem Cells Dev, 24 (24): 2925-2942. doi:10.1089/scd.2015.0131. PMID: 26414932. Li S, Xue H, Wu J, Rao MS, Kim D, Deng W, Liu Y. (2015) 2015
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The p38α mitogen activated protein kinase is a key regulator of myelination and remyelination in the CNS. Cell Death & Dis, (2015) 6, e1281. doi:10.1038/cddis.2015.119. Chung SH, Biswas S, Selvaraj V, Liu X-B, Sohn J, Jiang P, Chen C, Chmilewsky F, Marzban H, Horiuchi M, Pleasure DE, Deng W. (2015) 2015
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The subventricular zone continues to generate corpus callosum and rostral migratory stream astroglia in normal adult mice. J Neurosci, 35 (9):3756-3763. Sohn J, Orosco L, Guo F, Chung SH, Bannerman P, Mills Ko E, Zarbalis K, Deng W, Pleasure DE. (2015) 2015
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The Wnt effector transcription factor 7-like 2 positively regulates oligodendrocyte differentiation in a manner independent of Wnt/beta-catenin signaling. J Neurosci, 35 (12): 5007-5022. Hammond E, Lang J, Maeda Y, Pleasure D, Angus-Hill M, Xu J, Horiuchi M, Deng W, Guo F. (2015) 2015
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Kirenol attenuates experimental autoimmune encephalomyelitis by inhibiting differentiation of Th1 and Th17 cells and inducing apoptosis of effector T cells. Sci. Reports, 5, 9022; DOI:10.1038/srep09022 (2015). Xiao J, Yang R, Yang L, Fan X, Liu W, Deng W. (2015) 2015
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Empowering sonic hedgehog to rescue brain cells after ischemic stroke. Neural Regen Res, 10 (3): 360-362. doi: 10.4103/1673-5374.153677. PMID: 25878576 [PubMed]. Chechneva OV, Deng W. (2015) 2015
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The tumor cytosol miRNAs, fluid miRNAs and exosome miRNAs in cancer. Front. Oncol. 4: 357. doi: 10.3389/fonc.2014.00357 (2015). PMID: 25601903 [PubMed]. Qin X, Xu H, Gong W, Deng W. (2015) 2015
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Mesenchymal stem cells and induced pluripotent stem cells as therapies for multiple sclerosis. Int. J. Mol. Sci. 16: 9283-9302; doi:10.3390/ijms16059283. Xiao J, Yang R, Biswas S, Qin X, Zhang M, Deng W. (2015) 2015
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p38α (MAPK14) critically regulates the immunological response and the production of specific cytokines and chemokines in astrocytes. Sci. Reports, 4: 7405; DOI:10.1038/srep07405 (2014). Lo U, Selvaraj V, Plane JM, Chechneva OV, Otsu, K, Deng W. 2014
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A smoothened receptor agonist is neuroprotective and promotes regeneration after ischemic brain injury. Cell Death & Dis, (2014) 5, doi:10.1038/cddis.2014.446. Chechneva OV, Mayrhofer F, Daugherty DJ, Krishnamurty RG, Bannerman P, Pleasure DE, Deng W. (2014) 2014
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Role of astroglia in Down’s syndrome revealed by patient-derived human-induced pluripotent stem cells. Nat. Commun. 5:4430 doi: 10.1038/ncomms5430 (2014). Chen C, Jiang P, Xue H, Peterson SE, Tran HT, McCann AE, Parast MM, Li S, Pleasure DE, Laurent LC, Loring JF, Liu Y, Deng W. 2014
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Stimuli-responsive cross-linked micelles for on-demand drug delivery against cancers. Adv Drug Deliv Rev, 2013 Sep 21. doi:pii: S0169-409X(13)00204-4. 10.1016/j.addr.2013.09.008. [Epub ahead of print] PubMed PMID: 24060922. Li Y, Xiao K, Zhu W, Deng W, Lam KS. 2013
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Translocator protein/peripheral benzodiazepine receptor is not required for steroid hormone biosynthesis. Endocrinology, 155 (1): 89-97. PMID: 24174323. *Co-correspondence authors. Morohaku K, Pelton SH, Daugherty DJ, Butler WR, Deng W*, Selvaraj V*. 2013
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hESC-derived Olig2+ progenitors generate a subtype of astrocytes that are highly protective against ischemic brain injury. Nature Communications, 4:2196 doi: 10.1038/ncomms3196. Jiang P, Chen C, Wang R, Chechneva OV, Chung S, Rao M, Pleasure DE, Liu Y, Zhang Q, Deng W. 2013
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A TSPO ligand is protective in a mouse model of multiple sclerosis. EMBO Mol Med, 5 (6): 891-903 Daugherty DJ, Selvaraj S, Chechneva OV, Liu X, Pleasure DE, Deng W. 2013
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Generation and characterization of spiking and nonspiking oligodendroglial precursor cells from embryonic stem cells. Stem Cells, 31 (9), doi: 10.1002/stem.1515. Jiang P, Chen C, Liu X, Selvaraj V, Liu W, Feldman DH, Liu Y, Pleasure DE, Li, RA, Deng W. 2013
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Olig2/Plp+ progenitor cells give rise to Bergmann glia in the cerebellum. Cell Death & Dis, 4:e546. doi:10.1038/cddis.2013.74. PMID: 23492777. Chung S, Guo F, Jiang P, Pleasure DE, Deng W. 2013
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Vulnerability of premyelinating oligodendrocytes to white matter damage in neonatal brain injury. Neurosci Bulletin, 29 (2): 229–238. PubMed ID: 23456565. Liu X, Shen Y, Plane JM, Deng W. 2013
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Transcriptional activation of the Prox1 gene by HIF-1α and HIF-2α in response to hypoxia. FEBS Lett 587 (6):724-731. Zhou B, Si W, Su Z, Deng W, Tu X, Wang Q. 2013
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Stem cell models for drug discovery and toxicology studies. J Biochem Mol Toxicol, 27 (1): 17-27. Liu W, Deng Y, Liu Y, Gong W, Deng W. 2013
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PEDF is a novel oligodendrogenic morphogen acting on the adult SVZ and corpus callosum. J Neurosci, 32 (35):12152-12164. Sohn J, Selvaraj V, Wakayama K, Orosco L, Lee E, Crawford SE, Guo F, Lang J, Horiuchi M, Zarbalis K, Itoh T, Deng W, Pleasure DE. 2012
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PARP-1 Deletion Promotes subventricular zone neural stem cells toward a glial fate. J Neurosci Res, doi: 10.1002/jnr.23040. Plane JM, Grossenbache SK, Deng W. 2012
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Differentiating human stem cells into neurons and glial cells for neural repair. Front Biosci. 2012 Jan 1;17:65-89. PubMed PMID: 22201733. Selvaraj V, Jiang P, Chechneva O, Lo UG, Deng W. 2012
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DNA polymerase-β mediates the neurogenic effect of β-amyloid protein in cultured subventricular zone neurospheres. J Neurosci Res. 2012 Mar;90(3):559-67. doi: 10.1002/jnr.22780. Epub 2011 Nov 4. PubMed PMID: 22057776; PubMed Central PMCID: PMC3259249. Calafiore M, Capani, A, Deng W. 2012
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Developmental regulation of group I metabotropic glutamate receptors in the premature brain and their protective role in a rodent model of periventricular leukomalacia. Neuron Glia Biol. 2011 Dec 14:1-12. [Epub ahead of print] PubMed PMID: 22169210. Jantzie LL, Talos DM, Selip DB, An L, Jackson MC, Folkerth RD, Deng W, Jensen FE. 2011
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Low dose dextromethorphan attenuates moderate experimental autoimmune encephalomyelitis by inhibiting NOX2 and reducing peripheral immune cells infiltration in the spinal cord. Neurobiol Dis, doi:10.1016/j.nbd.2011.06.004. Chechneva O, Mayrhofer F, Daugherty D, Pleasure D, Hong JS, and Deng W. 2011
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Apoptosis inducing factor deficiency causes reduced mitofusion 1 expression and patterned Purkinje cell degeneration. Neurobiology of Disease, 41: 445–457. Chung SH, Calafiore M, Plane JM, Pleasure DE, Deng W. 2011
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Neuroprotective potential of erythropoietin and its derivative carbamylated erythropoietin in periventricular leukomalacia. Experimental Neurology, 230: 227-239 Liu W, Shen Y, Plane JM, Pleasure DE, Deng W. 2011
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Olig gene targeting in human pluripotent stem cells for motor neuron and oligodendrocyte differentiation. Nature Protocols, 6(5): 640-655. The first two authors contributed equally to this work. Liu Y, Jiang P, Deng W. 2011
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Label-free detection of surface markers on stem cells by oblique-incidence reflectivity difference microscopy. BioTechniques, 50 (6): 381–388. Lo K, Sun Y, Landry JP, Zhu X, Deng W. 2011
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Axon-glia synapses are highly vulnerable to white matter injury in the developing brain. J Neurosci Res, DOI: 10.1002/jnr.22722. Shen Y, Liu X, Pleasure DE, Deng W. 2011

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Zfp488 promotes oligodendrocyte differentiation of neural progenitor cells in adult mice after cuprizone-induced demyelination. Nature Publishing Group: Scientific Reports, 1:1 doi:10.1038/srep2 (2011). Soundarapandian MM, Selvaraj V, Lo U, Golub MS, Feldman DH, Pleasure DE, Deng W. 2011
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Quiescent and active stages of endogenous adult neural stem cells: identification and characterization. Stem Cells, 29(6):907-912. Wang Y, Plane JM, Jiang P, Zhou C, Deng W. 2011
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Electrically guiding migration of human induced pluripotent stem cells. Stem Cell Rev Reports, DOI 10.1007/s12015-011-9247-5. PubMed ID: 21373881. *Co-correspondence authors. Zhang Jiaping, Marco Calafiore, Yuesheng Huang, Qunli Zeng, Xiuzhen Zhang, Ronald A. Li, Deng W*, Min Zhao*. 2011
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Neurobiology of injury to the developing brain. Nature Reviews Neurology, 6 (6): 328-336. Deng W. 2010
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Blood brain barrier breakdown and repair by src after thrombin-induced brain injury. Annals of Neurology, 67(4):526-533. Liu D, Ander BP, Xu H, Shen Y, Kaur P, Deng W, Sharp FR. 2010
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Prospects for minocycline neuroprotection. Arch Neurol, 67 (12), August 9, 2010. doi:10.1001/archneurol.2010.191. Plane JM, Shen Y, Pleasure DE, Deng W. 2010
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Exploiting pluripotency for therapeutic gain. Panminerva Medica, 52 (2): 167-173. PubMed ID: 20517198 Deng W. 2010
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AID in reprogramming: quick and efficient. BioEssays, 32 (5): 385-387. Deng W. 2010
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Mouse models of periventricular leukomalacia. J Vis Exp, 2010 May 18;(39). pii: 1951. doi: 10.3791/1951. Shen Y, Plane, JM, Deng W. 2010
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Differentiation of embryonic stem cells into oligodendrocyte precursors. J Vis Exp, 2010 May 19;(39). pii: 1960. doi: 10.3791/1960. Jiang P, Selvaraj V, Deng W. 2010
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Electrophysiological properties of human induced pluripotent stem cells. Am J Physiol Cell Physiol, 298 (3), C486-495. Jiang P, Rushing SN, Kong C, Fu J, Lieu D, Chan, C, Deng W, Li, R. 2010
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Induced pluripotent stem cells: paths to new medicines. EMBO reports, 11 (3), 161-165. Deng W. 2010
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Switching cell fate: the remarkable rise of induced pluripotent stem cells and lineage reprogramming technologies. Trends in Biotechnology, 28 (4): 214-223. Selvaraj V, Plane, JM, Williams AJ, Deng W. 2010
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PARP-1 deficiency increases the severity of disease in a mouse model of multiple sclerosis. (2009) J Biol Chem, July 2009, doi:10.1074/jbc.M109.013474. Vimal Selvaraj, Mangala Soundarapandian, Olga Chechneva, Ambrose J. Williams, Maxim K. Sidorov, Athena Soulika, David E. Pleasure and Deng W. 2009
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PARylation: strengthening the connection between cancer and pluripotency. Cell Stem Cell, 5: 349-350. Deng W. 2009
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Genome integrity: linking pluripotency and tumorgenicity. Trends in Genetics, 25 (10): 425-427. *Co-correspondence authors. Deng W*, Xu Y*. 2009
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Progress in periventricular leukomalacia. Arch Neurol 65, 1291-1295. 2008 Deng W, Pleasure J, Pleasure D. 2008
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Alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subunit composition and cAMP-response element-binding protein regulate oligodendrocyte excitotoxicity. J Biol Chem. 281(47):36004-11 Deng W, Neve RL, Rosenberg PA, Volpe JJ, Jensen FE. 2006
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Oligodendrocyte excitotoxicity determined by local glutamate accumulation and mitochondrial function. J. Neurochem. 98, 213-222. Deng W, Yue Q, Rosenberg PA, Volpe JJ, Jensen FE. 2006
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Role of metabotropic glutamate receptors in oligodendrocyte excitotoxicity and oxidative stress. Proc. Natl. Acad. Sci. USA 101, 7751-7756. Deng W, Wang H, Rosenberg PA, Volpe JJ, Jensen FE. 2004
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Glutamate receptor-mediated oligodendrocyte toxicity in periventricular leukomalacia: a protective role for topiramate. J. Neurosci. 24, 4412-4420. Follett PL, Deng W, Dai W, Talos DM, Massillon L, Rosenberg PA, Volpe JJ, Jensen FE. 2004
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Calcium-permeable AMPA/kainate receptors mediate toxicity and preconditioning by oxygen-glucose deprivation in oligodendrocyte precursors. Proc. Natl. Acad. Sci. USA 100, 6801-6806. Deng W, Rosenberg PA, Volpe JJ, Jensen FE. 2003
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Oligodendroglia in developmental neurotoxicity. Neurotoxicology 24, 161-178 178 (featured with cover illustration). Deng W, Poretz RD. 2003
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Protein kinase C activation is required for the lead-induced inhibition of proliferation and differentiation of cultured oligodendroglial progenitor cells. Brain Res. 929, 87-95. Deng W, Poretz RD. 2002
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Chronic dietary lead exposure affects galactolipid metabolic enzymes in the developing rat brain. Toxicol. Appl. Pharmacol. 172, 98-107. Deng W, Poretz RD. 2001
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Lead exposure delays the differentiation of oligodendroglial progenitors in vitro. Toxicol Appl Pharmacol 174, 235-244. Deng W, McKinnon RD, Poretz RD. 2001
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Lead alters the developmental profile of galactolipid metabolic enzymes in cultured oligodendrocyte lineage cells. Neurotoxicology 22, 429-437. Deng W, Poretz RD. 2001
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The interaction of lead exposure and arylsulfatase A genotype affects sulfatide catabolism in human fibroblasts. Neurotoxicology 21, 379-388. Poretz RD, Yang A, Deng W, Manowitz P. 2001
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