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Cho, Kiho

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Kiho Cho
Title:
Professor
Office Address: 2425 Stockton Blvd, Room 631
Sacramento, CA 95817
Office Phone:
(916) 453-2284
E-Mail Address: kcho (at) ucdavis.edu
Education: Seoul National University, Seoul, Korea, DVM
Seoul National University, Seoul, Korea, BS
University of California, Davis, PhD
Research Papers: Click Here for Research Paper Links

Research Interests:

My current research focuses on the role of endogeneous retroviruses (ERVs) and retroelements in determining burn injury response.

Current Research:

Currently, people use genes to explain why people respond the way they do to injury or disease. However, genes make up only ~3% of a person’s DNA. Furthermore, the genes between different people are over 99% similar.

This leads us to believe that genes cannot be the only reason why people respond so differently to injury, and that the key to understanding these differences may lie in the unexplored “other” ~97% of the DNA.

Endogenous retroelements are a major proportion of that “other” DNA. In our lab, we examine how these retroelements become active or inactive during injury. We think retroelements may play a fundamental role in understanding why individuals respond so uniquely to burn injury and treatment. We hope to develop a new retroelement-based diagnostic tool to predict an individual burn patient’s response to injury and develop unique treatment therapies which will maximize their chances for a full recovery.


Noteworthy Publications:

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AUTHOR(s)
YEAR
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Genomic landscapes of endogenous retroviruses unveil intricate genetics of conventional and genetically-engineered laboratory mouse strains. Exp Mol Pathol. 11;100(2):248-256 Lee KH, Lim D, Chiu S, Greenhalgh D, Cho K. 2016
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Repetitive element signature-based visualization, distance computation, and classification of 1766 microbial genomes. Genomics. 106(1):30-42. Lee KH, Shin KS, Lim D, Kim WC, Chung BC, Han GB, Roh J, Cho DH, Cho K. 2015
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Temporal and spatial rearrangements of a repetitive element array on C57BL/6J mouse genome. Exp Mol Pathol. Jun;98(3):439-45. Lee KH, Yee L, Lim D, Greenhalgh D, Cho K. 2015
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Divergent and dynamic activity of endogenous retroviruses in burn patients and their inflammatory potential. Exp Mol Pathol. 96(2):178-87. Lee KH, Rah H, Green T, Lee YK, Lim D, Nemzek J, Wahl W, Greenhalgh D, Cho K. 2014
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Large interrelated clusters of repetitive elements (REs) and RE arrays predominantly represent reference mouse chromosome Y. Chromosome Res. 21(1):15-26. Lee KH, Kim WC, Shin KS, Roh JK, Cho DH, Cho K. 2013
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REViewer: A tool for linear visualization of repetitive elements within a sequence query. Genomics. S0888-7543(13)00145-6. You RN, Kim WC, Lee KH, Lee YK, Shin KS, Cho K, Cho DH. 2013
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Single nucleotide polymorphisms and type of steroid impact the functional response of the human glucocorticoid receptor. J Surg Res. S0022-4804(12)01965-8. Baker AC, Chew VW, Green TL, Tung K, Lim D, Cho K, Greenhalgh DG. 2013
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Injury-elicited stressors alter endogenous retrovirus expression in lymphocytes depending on cell type and source lymphoid organ. BMC Immunol. 14(1):2. Lee KH, Lim D, Green T, Greenhalgh D, Cho K. 2013
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Identification of a group of Mus dunni endogenous virus-like endogenous retroviruses from the C57BL/6J mouse genome: proviral genomes, strain distribution, expression characteristics, and genomic integration profile. Chromosome Res. 20(7):859-74. Lee KH, You RN, Greenhalgh DG, Cho K. 2012
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REMiner-II: A tool for rapid identification and configuration of repetitive element arrays from large mammalian chromosomes as a single query. Genomics. 100(3):131-40. Kim WC, Lee KH, Shin KS, You RN, Lee YK, Cho K, Cho DH. 2012
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ERE database: A database of genomic maps and biological properties of endogenous retroviral elements in the C57BL/6J mouse genome. Genomics. 100(3):157-61. Kao D, Hsu K, Chiu S, Tu V, Chew A, Lee KH, Lee YK, Kwon DN, Greenhalgh DG, Cho K. 2012
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Enhanced steroid response of a human glucocorticoid receptor splice variant. Shock. 38(1):11-7. Baker AC, Green TL, Chew VW, Tung K, Amini A, Lim D, Cho K, Greenhalgh DG. 2012


Age-dependent and tissue-specific structural changes in the C57BL/6J mouse genome. Exp Mol Pathol. 93(1):167-72. Lee KH, Chiu S, Lee YK, Greenhalgh DG, Cho K. 2012
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Unique Profile of Ordered Arrangements of Repetitive Elements in the C57BL/6J Mouse Genome Implicating Their Functional Roles. . PLoS One. 7(4):e35156. Lee YK, Lee KH, Kim SG, Melhem R, Moon CS, Liu S, Greenhalgh DG, Cho K 2012
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Cerebellum-specific and age-dependent expression of an endogenous retrovirus with intact coding potential. Retrovirology. 8:82. Lee KH, Horiuchi M, Itoh T, Greenhalgh DG, Cho K. 2011
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REMiner: a tool for unbiased mining and analysis of repetitive elements and their arrangement structures of large chromosomes. Genomics. 98(5):381-9. Chung BI, Lee KH, Shin KS, Kim WC, Kwon DN, You RN, Lee YK, Cho K, Cho DH. 2011
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Novel hyperactive glucocorticoid receptor isoform identified within a human population. Shock. 36(4):339-44. Tung K, Baker AC, Amini A, Green TL, Chew VW, Lim D, Nguyen ST, Yee KS, Cho K, Greenhalgh DG. 2011

Identification of a unique library of complex, but ordered, arrays of repetitive elements in the human genome and implication of their potential involvement in pathobiology. Exp Mol Pathol 90(3):300-311. Lee KH, Lee YK, Kwon DN, Chiu S, Chew V, Rah H, Kujawski G, Melhem R, Hsu K, Chung C, Greenhalgh DG, Cho K. 2011
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Lipopolysaccharide stress induced cell-type specific production of murine leukemia virus type-endogenous retroviral virions in primary lymphoid cells. J Gen Virol 92(Pt2):292-300. Kwon DN, Lee YK, Greenhalgh DG, Cho K. 2010
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Post-injury stress signals alter epigenetic profile of cytosine methylation in the proviral genome of endogenous retroviruses. Exp Mol Pathol 89(3):291-300. Chiu S, Hsu K, Greenhalgh DG, Cho K. 2010
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Cloning and characterization of endogenous retroviruses associated with postinjury stress signals in lymphoid tissues. Shock 32(1):80-8. Kwon DN, Greenhalgh DG, Cho K. 2009

Experimental polymicrobial peritonitis-associated transcriptional regulation of murine endogenous retroviruses. Shock 32(2):147-58. Cho K, Chiu S, Lee YK, Greenhalgh D, Nemzek J. 2009
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2425 Stockton Blvd.
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