Personal tools

Borodinsky, Laura

Document Actions
Laura Borodinsky MD
Title:
Assistant Professor
Associate Investigator
Office Address: 2425 Stockton Blvd
Sacramento, CA 95817
Office Phone:
(916) 453-2285
E-Mail Address: lnborodinsky (at) ucdavis.edu
Education: 1993 Master in Chemistry - University of Buenos Aires
1999 Ph.D. in Neurosciences - University of Buenos Aires
Research Papers: Click Here for Research Paper Links

Research Interests:

Developmental neuroscience, neural tube defects, spinal cord development, neuronal differentiation, spinal cord and muscle regeneration.

Current Research:

Current research projects in our lab share a common goal of understanding the cellular and molecular mechanisms by which electrical activity, environmental factors and in general, changes in extrinsic and intrinsic cues influence nervous system development and regeneration. Different forms of activity are present at early stages of development, substantially before synapse formation, suggesting that neuronal activity participates in early steps of neuronal differentiation.

The hypotheses that we are testing in each of these projects attempt to challenge the idea that development occurs exclusively by a hardwired genetic program. Instead, we argue that tissue development progresses through a dynamic interplay between genetic programs and variable intrinsic and extrinsic cues.

We investigate the mechanisms by which two environmental factors, folic acid and antiepileptic drugs influence the incidence of neural tube defects. Our lab works with Xenopus laevis as a model system using a combination of methodologies including confocal microscopy, immunostaining, molecular biology, pharmacology, calcium imaging and electrophysiology.

Other projects in the lab are focused on spinal cord and muscle development and regeneration and the interplay between electrical activity and morphogenetic protein signaling.


Noteworthy Publications:

TITLE
AUTHOR(s)
YEAR
DOWNLOAD
Calcium signaling in skeletal muscle development, maintenance and regeneration. Cell Calcium, 59(2-3): 91-97. Tu MK, Levin JB, Hamilton AM, Borodinsky LN. 2016
HTML
PDF
Crosstalk among electrical activity, trophic factors and morphogenetic proteins in the regulation of neurotransmitter phenotype specification. J Chem Neuroanat, 73:3-8. Borodinsky LN, Belgacem YH. 2016
HTML
PDF
Invited co-editors, Second messengers in neuronal development, Special Issue, Developmental Neurobiology, 75: 335-336. Kamiguchi H and Borodinsky LN. 2015
HTML
PDF
Inversion of Sonic hedgehog action on its canonical pathway by electrical activity. PNAS, 112: 4140-4145. Belgacem YH, Borodinsky LN. 2015
HTML
PDF
Regulation of neuronal development: Spatiotemporal integration of multiple developmental cues and second messengers. Invited review, Developmental Neurobiology, 75: 349-359. Borodinsky LN, Belgacem YH, Swapna I, Visina O, Balashova OA, Tu, MK, Sequerra EB, Levin JB, Spencer KA, Castro PA, Hamilton AM, Shim S. 2015
HTML
PDF
Leukotriene B4 activates intracellular calcium and augments human osteoclastogenesis. Arthritis Research & Therapy, 16: 496. Dixit N, Wu D, Belgacem YH, Borodinsky LN, Gershwin M, Adamopoulos IE. 2014
HTML
PDF
Spontaneous calcium transients manifest in the regenerating muscle and are necessary for skeletal muscle replenishment. Cell Calcium, 56: 34-41. Tu MK, Borodinsky LN. 2014
HTML
PDF
Dynamic regulation of neurotransmitter specification: Relevance to nervous system homeostasis. Neuropharmacology, 78: 75–80. Borodinsky LN, Belgacem YH, Swapna I, Sequerra EB. 2014
HTML
PDF
Imaging and manipulating calcium transients in developing Xenopus spinal neurons. Cold Spring Harbor Protocols. doi:10.1101/pdb.prot066803. Spitzer NC, Borodinsky LN, Root CM. 2013
HTML
PDF
Interplay between electrical activity and BMP signaling regulates spinal neuron differentiation. PNAS, 109, 16336-16341. Swapna I, Borodinsky LN 2012
HTML
PDF
Electrical activity as a developmental regulator in the formation of spinal cord circuits. Invited review. Current Opinion in Neurobiology, 22: 624-630. Borodinsky, LN, Belgacem YH, Swapna I. 2012
HTML
PDF
Imaging calcium transients in developing Xenopus spinal neurons. In Imaging in Developmental Biology: A Laboratory Manual. Sharpe J, Rachel Wong and Yuste R, Eds, Cold Spring Harbor Laboratory Press. Spitzer NC, Borodinsky LN, Root CM. 2011

Sonic hedgehog signaling is decoded by calcium spike activity in the developing spinal cord. PNAS, 108: 4482-4487. Belgacem YH, Borodinsky LN 2011
HTML
PDF
Developmental Regulation of Spinal Circuits. Invited review. Current Opinion in Neurobiology. In preparation Borodinsky, LN. In Press

Bone morphogenetic proteins regulate excitability in spinal neurons relevant for specification of dorsal phenotypes. Submitted. Swapna I, Borodinsky LN. In Press

Xenopus laevis as a model system for the study of neural tube defects induced by folic acid deficiency. Submitted. Visina O, Balashova OA, Borodinsky LN. In Press

Mechanisms of Synapse Formation: Activity-Dependent Selection of Neurotransmitters and Receptors. In “Co-Existence and Co-Release of Classical Neurotransmitters. Ex uno plures”. Gutierrez, Rafael, Ed., Springer. Borodinsky LN, Spitzer NC 2009
HTML
Implications of activity-dependent neurotransmitter-receptor matching. Philos. Trans. R. Soc. Lond B Biol Sci, 363: 1393-1399, 2008 Spitzer NC, Borodinsky LN. 2008
HTML
PDF
Activity-Dependent Neurotransmitter-Receptor Matching at the Neuromuscular Junction. PNAS, 104: 335-340. Borodinsky LN, Spitzer NC. 2007
HTML
PDF
Second messenger pas de deux: The coordinated dance between calcium and cAMP. Sci. STKE, 2006: pe22. Borodinsky LN, Spitzer NC 2006
HTML
PDF
Homeostatic activity-dependent paradigm for neurotransmitter specification. Cell Calcium, 37: 417-423. Spitzer NC, Borodinsky LN, Root CM 2005
HTML
PDF
Imaging calcium transients in developing Xenopus spinal neurons. In "Imaging in neuroscience and development: A laboratory manual". Spitzer NC, Borodinsky LN, Root CM. 2005

Orchestrating neuronal differentiation: patterns of Ca2+ spikes specify transmitter choice. Trends Neurosci 27: 415-421. Spitzer NC, Root CM, Borodinsky LN 2004
HTML
PDF
Activity-dependent homeostatic specification of transmitter expression in embryonic neurons. Nature 429: 523-530. Borodinsky LN, Root CM, Cronin J, Sann SB, Gu X, Spitzer NC. 2004
HTML
PDF
Evidence of oxidative stress in familial amyloidotic polyneuropathy type 1. Arch Neurol 60: 593-597. Fiszman ML, Di Egidio M, Ricart KC, Repetto MG, Borodinsky LN, Llesuy SF, Saizar RD, Trigo PL, Riedstra S, Costa PP, Villa AM, Katz N, Lendoire JC, Sica RE. 2003
HTML
PDF
GABA-induced neurite outgrowth of cerebellar granule cells is mediated by GABAA receptor activation, calcium influx and CaMKII and MEK1 pathways. J Neurochem 84: 1411-1420. Borodinsky LN, O’Leary D, Neale JH, Vicini S, Coso OA, Fiszman ML 2003
PDF
Contribution of Ca2+-calmodulin-dependent protein kinase II and mitogen-activated protein kinase kinase on neural activity-induced neurite outgrowth and survival of cerebellar granule cells. J Neurochem 80: 1062-1070. Borodinsky LN, Coso OA, Fiszman ML 2002
PDF
IPRM
2425 Stockton Blvd.
Sacramento, CA 95817
Tele: (916) 453-2227
Fax: (916) 453-2288
webmaster (at) iprmd.org