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Adamopoulos, Iannis

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Iannis E. Adamopoulos
Title:
Associate Professor of Medicine
Principal Investigator
Office Address: 2425 Stockton Blvd., RM 650
Sacramento, CA 95817
Office Phone:
(916) 453-2237
E-Mail Address: iannis@ucdmc.ucdavis.edu
Education: Postdoctoral Fellow DNAX research institute, Palo Alto, CA
DPhil University of Oxford, UK
M,Phil University College London, UK
Research Papers: Click Here for Research Paper Links

Research Interests:

Osteoclast differentiation and activation, immune bone loss, inflammatory arthritis

Current Research:

Our laboratory studies the interface between the skeletal and immune systems, a newly emerging area of research called “osteoimmunology”. Haematopoietic stem cells in the bone marrow give rise to both T cells which are important in inflammation and osteoclasts that regulate bone resorption. Differentiation and activation of osteoclasts from their precursors is tightly regulated by cytokines and growth factors such as receptor activator of nuclear factor Kappa Beta (RANKL), tumor necrosis factor (TNF) and various Interleukins. Receptor engagement of these molecules results in signaling cascades and transcriptional changes that give rise to medical conditions such as Rheumatoid arthritis, osteoporosis and osteopetrosis. Using in vivo gene transfer of immune cytokines IL-23 and IL-17 we have established new arthritis animal models that highlight the importance of these immune cytokines in arthritis initiation and bone homeostasis. Using in vitro assays we continue our attempts to define the cellular and molecular mechanisms that take place in this fascinating interplay of the immune and skeletal systems.

For more information please visit the Adamopoulos lab homepage at: Adamopoulos Lab Homepage


Noteworthy Publications:

TITLE
AUTHOR(s)
YEAR
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Autophagy-linked FYVE containing protein WDFY3 interacts with TRAF6 and modulates RANKL-induced osteoclastogenesis. J Autoimmun. 2016 Jun 18. pii: S0896-8411(16)30082-8. doi: 10.1016/j.jaut.2016.06.004. [Epub ahead of print] PMID: 27330028 Wu DJ, Gu R, Sarin R, Zavodovskaya R, Chen CP, Christiansen BA, Adamopoulos IE. 2016
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IL-17A gene transfer induces bone loss and epidermal hyperplasia associated with psoriatic arthritis. Ann Rheum Dis. 2015 Jun;74(6):1284-92. doi: 10.1136/annrheumdis-2013-204782. Epub 2014 Feb 23. PMID: 24567524 Free PMC Article Adamopoulos IE, Suzuki E, Chao CC, Gorman D, Adda S, Maverakis E, Zarbalis K, Geissler R, Asio A, Blumenschein WM, Mcclanahan T, De Waal Malefyt R, Gershwin ME, Bowman EP. 2015
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Alternative pathways of osteoclastogenesis in inflammatory arthritis. Nat Rev Rheumatol. 2015 Mar;11(3):189-94. doi: 10.1038/nrrheum.2014.198. Epub 2014 Nov 25. Review. PMID: 25422000 Free PMC Article Adamopoulos IE, Mellins ED. 2015
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Crosstalk among IL-23 and DNAX Activating Protein of 12 kDa-Dependent Pathways Promotes Osteoclastogenesis. J Immunol. 2015 Jan 1;194(1):316-24. doi: 10.4049/jimmunol.1401013. Epub 2014 Dec 1. PMID: 25452564 Free PMC Article Shin HS, Sarin R, Dixit N, Wu J, Gershwin E, Bowman EP, Adamopoulos IE. J Immunol. 2015 Jan 1;194(1):316-24. doi: 10.4049/jimmunol.1401013. Epub 2014 Dec 1. 2015
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Leukotriene B4 activates intracellular calcium and augments human osteoclastogenesis. Dixit N, Wu DJ, Belgacem YH, Borodinsky LN, Gershwin M, Adamopoulos IE. Arthritis Res Ther. 2014 Dec 2;16(6):496. [Epub ahead of print] 2014
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Alternative pathways of osteoclastogenesis in inflammatory arthritis. Adamopoulos IE and Mellins ED. Nat Rev Rheumatol. 2014 Nov 25. doi: 10.1038/nrrheum.2014.198. [Epub ahead of print] 2014
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Anti-Kelch-like 12 and Anti-Hexokinase 1: Novel Autoantibodies in Primary Biliary Cirrhosis. Norman GL, Yang CY, Ostendorff HP, Shums Z, Lim MJ, Wang J, Awad A, Hirschfield GM, Milkiewicz P, Bloch DB, Rothschild KJ, Bowlus CL, Adamopoulos IE, Leung PS, Janssen HJ, Cheung AC, Coltescu C, Gershwin ME. Liver Int. 2014 Sep 19. doi: 10.1111/liv.12690. [Epub ahead of print] 2014
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Loss of Wdfy3 in mice alters cerebral cortical neurogenesis reflecting aspects of the autism pathology. Orosco LA, Ross AP, Cates SL, Scott SE, Wu D, Sohn J, Pleasure D, Pleasure SJ, Adamopoulos IE, Zarbalis KS. Nat Commun. 2014 Sep 8;5:4692. doi: 10.1038/ncomms5692 2014
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The IL-23/IL-17 axis in psoriatic arthritis Suzuki E, Mellins ED, Gershwin ME, Nestle FO, Adamopoulos IE. Autoimmun Rev. 2014 Jan 11. pii: S1568-9972(14)00062-7. doi: 10.1016/j.autrev.2014.01.050. [Epub ahead of print] 2014
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A Novel In Vivo Gene Transfer Technique and In Vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders. Dennis J Wu, Neha Dixit, Thanh Nguyen, Erika Suzuki, Hyun Seock Shin, Jack Davis, Emanual Maverakis, Iannis E Adamopoulos. Journal or Visualized Experiments 2014 e51810, doi:10.3791/51810. 2014
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A mutation in mouse Pak1ip1 causes orofacial clefting while human PAK1IP1 maps to 6p24 translocation breaking points associated with orofacial clefting. Plos One. 2013 Jul 25;8(7):e69333 AP Ross, MA Mansilla, Y Choe, S Helminski, R Sturm, RL Maute, SR May, KK Hozyasz, P Wójcicki, A Mostowska, B Davidson, IE Adamopoulos, SJ Pleasure, JC Murray, KS Zarbalis 2013
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The Implication of Vitamin D and Autoimmunity: a Comprehensive Review. Clinical Reviews in Allergy & Immunology. Epub 2013 Jan 29 CY Yang, PS Leung, IE Adamopoulos, ME Gershwin. 2013
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The emerging role of Interleukin 27 in inflammatory arthritis. Cytokine Growth Factor Rev. 2013 Apr;24(2):115- IE Adamopoulos, S Pflanz. and bone destruction 2013
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Rheumatoid and pyrophosphate arthritis synovial fibroblasts induce osteoclastogenesis independently of RANKL, TNF and IL-6 signaling pathways. Journal of Autoimmunity. 2012 Dec;39(4):369-76 TJ Dickerson, E Suzuki, C Stanecki, HS Shin, H Qiu, IE Adamopoulos. 2012
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IL-23 is critical for the induction of arthritis, osteoclast formation and maintenance of bone mass. Journal of Immunology 2011 (in press) IE Adamopoulos, M Tessmer, CC Chao, S. Adda, D. Gorman, M Petro, CC Chu, RH Pierce, W Yao, NE Lane, D. Laface, EP Bowman. 2011

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Anti-IL-17A therapy protects against bone erosion in experimental models of rheumatoid arthritis. Autoimmunity May 44(3):243-52 CC Chao, SJ Chen, IE Adamopoulos, N Davis, K Hong, A Vu, S Kwan, L Fayadat-Dilman, A Asio, EP Bowman. 2011
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Myeloid DAP12- associating lectin (MDL)-1 receptor regulates synovial inflammation and bone erosion associated with autoimmune arthritis. Journal of Experimental Medicine 2010 Mar 15;207(3):579-89. B Joyce-Shaikh, M. Bigler, CC Chao, E. Murphy, IE Adamopoulos, P. Heyworth, E. Bowman, T. McClanahan, J. Phillips and DJ Cua 2010

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Structural, cellular, and molecular evaluation of bone erosion in experimental arthritis models: assessment by μCT, histology, and serum biomarkers Autoimmunity 2010 Dec;43(8):642-53 CC Chao, SJ Chen, IE Adamopoulos, EP Bowman. 2010
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Interleukin-17A upregulates receptor activator of NF-kappaB on osteoclast precursors. Arthritis Research and Therapy. 2010 Feb 18;12(1):R29 IE Adamopoulos, CC Chao, R Geissler, DM Laface, W Blumenschein, T McClanahan and EP Bowman 2010

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A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis. Nature Medicine. 2009 Jul;15(7):781-7 T Muchamuel, M Basler, M Aujay, E Suzuki, K Kalim, C Laurer, C Sylvain, E Ring, J Shields, J Jiang, P Shwonek, F Parlati, SD Demo, MK Bennett, CJ Kirk and M Groettrup 2009

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Immune regulation of bone loss by Th17 cells. Arthritis Research and Therapy 2008;10(5):225 IE Adamopoulos and EP Bowman 2008

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Fine mapping of the MHC Class III region demonstrates association of AIF1 and rheumatoid arthritis. Rheumatology (Oxford) 2008;47(12):1761-7 SJ Harney, C Vilariño-Güell, IE Adamopoulos, AM Sims, RW Lawrence, LR Cardon, JL Newton, C Meisel, JJ Pointon, C Darke, NA Athanasou, BP Wordsworth, MA Brown. 2008
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Quantification of bone resorption in experimental model of arthritis by a novel software “Osteo-Pro”. Journal of Computational Methods in Science and Engineering 2007;7(2):87-91 IE Adamopoulos and K Pataridis 2007

Cellular and humoral mechanisms of osteoclast formation in Ewing’s Sarcoma. British Journal of Cancer 2007;96(11):1716-22 YS Lau, IE Adamopoulos, H Giele, CLMH Gibbons, NA Athanasou. 2007
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A novel computational method to quantify and analyse osteoclastic bone resorption. Journal of Computational Methods in Science and Engineering 2007;7(2):87-91 IE Adamopoulos and K Pataridis. 2007
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Hepatocyte growth factor can substitute for M-CSF to support osteoclastogenesis. Biochemical and Biophysical research communications 2006;350(2):478-83 IE Adamopoulos, Z Xia, YS Lau, NA Athanasou 2006

Osteoclast differentiation and bone resorption in multicentric reticulohistiocytosis. Human Pathology 2006;37(9):1176-85 IE Adamopoulos, BP Wordsworth, JR Edwards, DJ Ferguson, NA Athanasou. 2006

LIGHT (TNFSF14), a novel mediator of bone resorption, is elevated in rheumatoid arthritis. Arthritis and Rheumatism 2006;54(5):1451-1462 JR Edwards, S Sun, R Locklin, C Shipman, IE Adamopoulos, NA Athanasou, A Sabokbar 2006

Hepatocyte growth factor in normal and diseased bone and joint tissues. Current Rheumatology Reviews 2006;2(1):1-7 IE Adamopoulos and NA Athanasou 2006

Synovial fluid macrophages are capable of osteoclast formation and resorption. Journal of Pathology 2006;208(1):35-43 IE Adamopoulos, A Sabokbar, BP Wordsworth, A Carr, DJ Ferguson, NA Athanasou 2006

Macrophage-mediated biodegradation of Poly (DL-lactide-co-glycolide) in vitro. Journal of Biomedical Materials Part A 2006;79(3):582-90 Z Xia, Y Huang, A Walpole, IE Adamopoulos, J Triffitt, Z Cui. 2006
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Stimulation of osteoclast formation and resorption by inflammatory arthritis synovial fluid. Virchows Archives 2006;449(1):69-77 IE Adamopoulos, L Danks, I Itonaga, R Locklin, A Sabokbar, DJ Ferguson, NA Athanasou. 2006
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In vitro biodegradation of three brushite calcium phosphate cements by a macrophage cell-line. Biomaterials 2006;27(26):4557-65 Z Xia, LM Grover, Y Huang, IE Adamopoulos, U Gbureck, JT Triffitt, RM Shelton, JE Barralet. 2006
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IPRM
2425 Stockton Blvd.
Sacramento, CA 95817
Tele: (916) 453-2227
Fax: (916) 453-2288
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