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David Pleasure, MD
Research Interests:
Development and regeneration of the nervous system; pathogenesis of demyelinative diseases.
Current Research:
Mechanisms of CNS injury and repair in autoimmune demyelinative diseases
Noteworthy Publications:
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Lrp6-mediated canonical Wnt signaling is required for lip formation and fusion.
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Song L, Li Y, Wang K, Wang YZ, Molotkov A, Gao L, Zhao T, Yamagami T, Wang Y, Gan Q, Pleasure DE, Zhou CJ. Development. 2009 Sep;136(18):3161-71.
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2009
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PARP-1 deficiency increases the severity of disease in a mouse model of multiple sclerosis.
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Selvaraj V, Soundarapandian MM, Chechneva O, Williams AJ, Sidorov MK, Soulika AM, Pleasure DE, Deng W. J Biol Chem. 2009 Jul 23. [Epub ahead of print]
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2009
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Early postnatal proteolipid promoter-expressing progenitors produce multilineage cells in vivo.
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Guo F, Ma J, McCauley E, Bannerman P, Pleasure D. J Neurosci. 2009 Jun 3;29(22):7256-70
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2009
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Impaired regenerative response of primary sensory neurons in ZPK/DLK gene-trap mice.
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Itoh A, Horiuchi M, Bannerman P, Pleasure D, Itoh T. Biochem Biophys Res Commun. 2009 May 29;383(2):258-62. Epub 2009 Apr 7.
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2009
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Ocular coloboma and dorsoventral neuroretinal patterning defects in Lrp6 mutant eyes.
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Zhou CJ, Molotkov A, Song L, Li Y, Pleasure DE, Pleasure SJ, Wang YZ. Dev Dyn. 2008 Dec;237(12):3681-9
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2008
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Activation of the Wnt/beta-catenin signaling reporter in developing mouse olfactory nerve layer marks a specialized subgroup of olfactory ensheathing cells.
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Wang YZ, Molotkov A, Song L, Li Y, Pleasure DE, Zhou CJ. Dev Dyn. 2008 Nov;237(11):3157-68.
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2008
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Characterization of acid-sensing ion channel expression in oligodendrocyte-lineage cells. Glia Early View, PUBLISHED ONLINE May 1, 2008, in advance of print.
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Feldman DH, Horiuchi M, Keachie K, McCauley E, Bannerman P, Itoh A, Itoh T, Pleasure D
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2008
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Bone morphogenetic proteins 4, 6, and 7 are upregulated in mouse spinal cord during experimental autoimmune encephalomyelitis. J Neurosci Res 86:125-135, 2008.
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Ara, See, Mamntov, Citrin, Bannerman, Pleasure, and Grinspan
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2008
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MEK-ERK signaling is involved in interferon-γ-induced death of oligodendroglial progenitor cells. J Biol Chem 281:20095-20106.
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Horiuchi, Itoh, Pleasure, Itoh
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2007
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Astrogliosis in EAE spinal cord: derivation from radial glia, and relationships to oligodendroglia. Glia 5:57-64.
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Bannerman, Hahn, Soulika, Gallo, Pleasure
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2006
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Motor neuron pathology in thy1-YFP transgenic mice with experimental autoimmune encephalomyelitis. Brain 128:1877-1886
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Bannerman, Hahn, Ramirez, Bonnemann, Yu, Rostami, Pleasure
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2005
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A Schwann cell autonomous role of neuropilin-2. J Neurosci Res 79:468-475
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Ara, Bannerman, Shaheen, Pleasure
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2005
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Induction of neuropilins -1 and -2 and their ligands, Sema3A, Sema3F, and VEGF, during Wallerian degeneration in the peripheral nervous system. Exp Neurol 183:489-498.
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Scarlato, Ara, Bannerman, Scherer, Pleasure
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2003
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Acidosis has opposite effects on neuronal survival during hypoxia and reoxygenation. J Neurochem 84:1018-1027.
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Almaas, Pytte, Lindstad, Wright, Saugstad, Pleasure, Rootwelt
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2003
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(Editors) Neurology, Rudolph's Pediatrics, McGraw Hill, New York, 2003, pp 2165-2350.
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Pleasure and Di Vito
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2003
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Tumor necrosis factor alpha increases neuronal vulnerability to excitotoxic necrosis by inducing expression of the AMPA-glutamate receptor subunit, GluR1, via an acid sphingomyelinase- and NFKappaB-dependent mechanism. Neurobiol Disease 11:199-213.
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Yu, Cheng, Wen, Wu, Lee, Pleasure
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2002
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Acute and chronic alterations in calcium homeostasis in 3-nitropropionic acid-treated human NT2-N neurons. Neuroscience 113:699-708.
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Lee, Itoh, Pleasure
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2002
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AMPA glutamate receptor-mediated calcium signaling is transiently enhanced during development of oligodendrocytes. J Neurochem 81:390-402.
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Itoh (T), Beesley, Itoh (A), Cohen, Kavanaugh, Coulter, Grinspan, Pleasure
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2002
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